A collaborative effort spearheaded by Alejandro Rojas-Fernandez and Lina Herhaus, from the Hay (GRE) and Sapkota (MRC-PPU) labs respectively, has led to the publication of a methodology paper in Scientific Reports for rapidly generating endog …more

The deubiquitylase OTUB1 is ubiquitously expressed and is known to impact key cellular processes, from TGFÃ_Â_ and p53 signalling to DNA damage repair, by targeting a multitude of substrates both in the cytoplasm and nucleus. Until now it was not kno …more

â€â€_Many congratulations to Gerrit Daubner, a postdoctoral researcher working in Dario Alessi's group, who has been awarded a prestigious personal long-term EMBO F …more

Congratulations to Lina Herhaus and Mazin Al-Salihi, of Gopal Sapkota's lab, for publishing a paper in Open Biology that describes how USP15 regulates the BMP pathway by deubiquitylating the type I BMP receptor, ALK3.



BMPs bel …more

Bone morphogenetic proteins (BMPs) control multiple cellular processes in embryos and adult tissues. BMPs signal through the activation of type I BMP receptor kinases, which then phosphorylate SMADs 1/5/8. In the canonical pathway, this triggers the  …more

Congratulations to Lina Herhaus, PhD student in Gopal Sapkota's lab, on being a recipient of the 2013 Tim Hunt Prize for Cell Biology for her work on elucidating the role of OTUB1 in the TGF-beta pathway.

The Tim Hunt prize for Cell Bi …more

Lina Herhaus, PhD student in Gopal Sapkota's lab, has published a paper on the role of OTUB1 in TGFÃ_Â_ signalling in Nature Communications.

The TGFÃ_Â_ signalling pathway controls plethora of cellular functions during embryogenesis a …more

Gopal Sapkota has published a single-author research paper in Open BIology that puts a question mark on the notion that transforming growth factor beta (TGFÃ_Â_) activates TGFÃ_Â_ Activated Kinase 1 (TAK1).



The activation of p …more

The transforming growth factor-Ã_Â_ (TGFÃ_Â_) signalling pathway plays critical roles through embryogenesis and in adult tissue homeostasis. Consequently, abnormal TGFÃ_Â_ signalling is associated with numerous human diseases, including immune disord …more

Abdulla Ibrahim, a medical student from the University of Dundee, has been awarded a Pathological Society of Great Britain and Ireland bursary to undertake a re …more