Congratulations to Lina Herhaus and Mazin Al-Salihi, of Gopal Sapkota's lab, for publishing a paper in Open Biology that describes how USP15 regulates the BMP pathway by deubiquitylating the type I BMP receptor, ALK3.



BMPs bel …more

Bone morphogenetic proteins (BMPs) control multiple cellular processes in embryos and adult tissues. BMPs signal through the activation of type I BMP receptor kinases, which then phosphorylate SMADs 1/5/8. In the canonical pathway, this triggers the  …more

Congratulations to Lina Herhaus, PhD student in Gopal Sapkota's lab, on being a recipient of the 2013 Tim Hunt Prize for Cell Biology for her work on elucidating the role of OTUB1 in the TGF-beta pathway.

The Tim Hunt prize for Cell Bi …more

Lina Herhaus, PhD student in Gopal Sapkota's lab, has published a paper on the role of OTUB1 in TGFÃ_Â_ signalling in Nature Communications.

The TGFÃ_Â_ signalling pathway controls plethora of cellular functions during embryogenesis a …more

Gopal Sapkota has published a single-author research paper in Open BIology that puts a question mark on the notion that transforming growth factor beta (TGFÃ_Â_) activates TGFÃ_Â_ Activated Kinase 1 (TAK1).



The activation of p …more

The transforming growth factor-Ã_Â_ (TGFÃ_Â_) signalling pathway plays critical roles through embryogenesis and in adult tissue homeostasis. Consequently, abnormal TGFÃ_Â_ signalling is associated with numerous human diseases, including immune disord …more

Abdulla Ibrahim, a medical student from the University of Dundee, has been awarded a Pathological Society of Great Britain and Ireland bursary to undertake a re …more

New Group Leader Gopal Sapkota arrived in Dundee on the 1st November to start his laboratory in the TGFbeta signalling pathway. Previously Gopal worked for five years in Joan Massagué's laboratory at the Memorial Sloan-Kettering Cancer Centre, New …more

In November 2003, Gopal Sapkota, a former PhD student with Dario Alessi, was awarded a Damon Runyon postdoctoral fellowship by the Damon Runyon Cancer Research Foundation. Gopak was one of 19 recipients of this prestigious award, selected from a pool …more

Dario Alessi and two PhD students from the Unit, Nimesh Mody and Gopal Sapkota, recently attended the FASEB meeting on protein kinases held in Snowmass, Colorado. Dario was presenting a seminar at the meeting, whilst Nimesh and Gopal presented poster …more