Mutations leading to inappropriate activation of Akt isoforms contribute to proliferation and survival of a significant proportion of human cancers. Akt is activated by phosphorylation of its T-loop residue (Thr308) by the 3-phosphoinositide dependen …more

Fiona Brown who works in the Division of Signal Transduction Therapy Unit is participating in a very major charity event that is taking place this Saturday called Strictly Come Dance for Insight.



Fiona with her partner Scott  …more

The Infections and Immunity Board of the UK Medical Research Council (MRC) has awarded a grant of almost £1.5 million to Philip Cohen and his team to carry out research over the next five years on the mechanisms that prevent inflammatory and autoimmu …more

The International Centre for Kinase Profiling launched a new lipid kinase profiling service on 1st July 2012. These 17 lipid kinases will compliment the protein kinase profiling panel of 139 enzymes.

The lipid kinase panel includes PI3Kina …more

At an international conference held at Dundee from Jun 24th-26th to mark Philip Cohen's 21 years as the Director of the MRC Protein Phosphorylation Unit, Philip was presented with an "Outstanding Contributor Award" from the Biochemical Journal by Pe …more

We are pleased to announce that Vicky Cowling and her research group including PhD Students (Thomas Gonatopoulos-Pournatzis, Michael Aregger, Sianadh Dunn, Anna Kelner, Laura Grasso) and postdoc (Nicola Phillips) will be moving into the MRC PPU on Ju …more

Saif El-Din Shehata graduated from the University of Dundee with a MSc by Research on Thursday June 21st 2012. He did his MSc in the lab of Professor Kei Sakamoto at the MRC PPU, Kei is now working at the Nestle Institute for Health Science (NIHS), …more

The transforming growth factor-Ã_Â_ (TGFÃ_Â_) signalling pathway plays critical roles through embryogenesis and in adult tissue homeostasis. Consequently, abnormal TGFÃ_Â_ signalling is associated with numerous human diseases, including immune disord …more

A new affinity tag for the purification of recombinant proteins termed the ‘Dac-tag' has been developed by Axel Knebel who is the head of the Protein Production and Assay Development team at SCILLS. Together with the MRC and SCILLS cloning team …more

Eeva Sommer, a PhD student in Dario Alessi's lab, working on the role of SGK in cancer, recently got married. What was most impressive was that Eeva was still in the lab on the Friday, the day before the wedding and back in the lab again on Monday.  …more