Chandana Kondapalli who has been supervised by Miratul Muqit and Dario Alessi over the last 4 years on a project to uncover the function of the PINK1 kinase has been awarded her PhD. Her examiners were  …more

Congratulations to Dennis Castor and Nidhi Nair who have published a paper which solves a long-standing problem regarding how cells deal with chromosome 'tangles' that link them in a way that is deleterious to cell function. Holliday junctions are 4- …more

Researchers at the University of Dundee have played a key role in the development of a new anti-cancer drug targeting melanoma.

GlaxoSmithKline have announced that their BRAF protein kinase inhibitor Dabra …more

We are delighted to announce that Karim Labib and his current lab, consisting of Pedro Nkosi (Senior Scientific Officer), Marija Maric (PhD student) and Cecile Evrin (postdoc), have joined the MRC Protein Phosphorylation and Ubiquitylation Unit ( …more

Lina Herhaus, PhD student in Gopal Sapkota's lab, has published a paper on the role of OTUB1 in TGFÃ_Â_ signalling in Nature Communications.

The TGFÃ_Â_ signalling pathway controls plethora of cellular functions during embryogenesis a …more

The MRC-PPU support teams and PIs have generated an impressive array of reagents for the study of the ubiquitylation system. This stimulated the establishment of the start-up company, Ubiquigent which exploits research and expertise based in the PPU. …more

A series of discoveries made by scientists at the University of Dundee is helping to uncover the secrets of how chronic inflammatory and autoimmune diseases such as Lupus and rheumatoid arthritis are caused and could lead to new treatments being deve …more

In this paper a collaboration between Sambit Nanda in Philip Cohen's lab and David Powell at the University of Kentucky, has led to the discovery that mutations in ABIN1 predispose to a partic …more

In this paper Eduardo Pauls and Sambit Nanda in Philip Cohen's lab have identified unique and distinctive roles for two members of the IRAK sub-family of protein kinases, which suggest that t …more

In this paper Christoph Emmerich and Sam Strickson in Philip Cohen's lab have made several surprising findings about the structure and formation of the polyubiquitin chains that control the pr …more