The University of Dundee's award-winning Division of Signal Transduction Therapy (DSTT) has this week celebrated the 50th meeting of the collaboration, which brings scientists at the University together with the world's biggest pharmaceutical com …more

RING-in-between-RING (RBR) enzymes are a distinct class of E3 ubiquitin ligases possessing a cluster of three zinc-binding domains that cooperate to catalyze ubiquitin transfer. The best known members of this group are PARKIN and HOIP, defects in whi …more

We are delighted to announce that Helen Walden and her PhD student Mark Frost have joined the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU). Helen has relocated her laboratory from the CRUK London Research Institute at Lincoln's I …more

Congratulations to Dennis Castor and Nidhi Nair who have published a paper which solves a long-standing problem regarding how cells deal with chromosome 'tangles' that link them in a way that is deleterious to cell function. Holliday junctions are 4- …more

Congratulations to Jamie Wilson (a Wellcome Trust Clinical Fellow in John Rouse's lab) who made a big advance in understanding SLX4 with help from Agueda Tejera in Maria Bla …more

Chandana Kondapalli who has been supervised by Miratul Muqit and Dario Alessi over the last 4 years on a project to uncover the function of the PINK1 kinase has been awarded her PhD. Her examiners were  …more

Researchers at the University of Dundee have played a key role in the development of a new anti-cancer drug targeting melanoma.

GlaxoSmithKline have announced that their BRAF protein kinase inhibitor Dabra …more

Lina Herhaus, PhD student in Gopal Sapkota's lab, has published a paper on the role of OTUB1 in TGFÃ_Â_ signalling in Nature Communications.

The TGFÃ_Â_ signalling pathway controls plethora of cellular functions during embryogenesis a …more

We are delighted to announce that Karim Labib and his current lab, consisting of Pedro Nkosi (Senior Scientific Officer), Marija Maric (PhD student) and Cecile Evrin (postdoc), have joined the MRC Protein Phosphorylation and Ubiquitylation Unit ( …more

The MRC-PPU support teams and PIs have generated an impressive array of reagents for the study of the ubiquitylation system. This stimulated the establishment of the start-up company, Ubiquigent which exploits research and expertise based in the PPU. …more