Research | Publications

Year

Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage

Duro, E., Vaisica, J. A., Brown, G. W., Rouse, J.

Principal Investigator(s):
John Rouse
2008
PubMed

Lithium prevents and ameliorates experimental autoimmune encephalomyelitis

De Sarno, P., Axtell, R. C., Raman, C., Roth, K. A., Alessi, D. R., Jope, R. S.

Principal Investigator(s):
Dario Alessi
2008
PubMed

p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation

Cuomo, M. E., Knebel, A., Morrice, N., Paterson, H., Cohen, P., Mittnacht, S.

Principal Investigator(s):
Philip Cohen
2008
PubMed

PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response

Belgardt, B. F., Husch, A., Rother, E., Ernst, M. B., Wunderlich, F. T., Hampel, B., Klockener, T., Alessi, D., Kloppenburg, P., Bruning, J. C.

Principal Investigator(s):
Dario Alessi
2008
PubMed

Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

Bayascas, J. R., Wullschleger, S., Sakamoto, K., Garcia-Martinez, J. M., Clacher, C., Komander, D., van Aalten, D. M., Boini, K. M., Lang, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., van Diepen, J. A., Voshol, P. J., Lucocq, J. M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2008
PubMed

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains

Al-Hakim, A. K., Zagorska, A., Chapman, L., Deak, M., Peggie, M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2008
PubMed

Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast

Sanchez-Diaz, A., Marchesi, V., Murray, S., Jones, R., Pereira, G., Edmondson, R., Allen, T., Labib, K.

Principal Investigator(s):
Karim Labib
2008
PubMed

Making connections at DNA replication forks: Mrc1 takes the lead

Labib, K.

Principal Investigator(s):
Karim Labib
2008
PubMed

The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development

Kulathu, Y., Hobeika, E., Turchinovich, G., Reth, M.

Principal Investigator(s):
Yogesh Kulathu
2008
PubMed

How is SOS activated? Let us count the ways

Findlay, G. M., Pawson, T.

Principal Investigator(s):
Greg Findlay
2008
PubMed

New insights into the chromosome cycle. Conference on the Replication & Segregation of Chromosomes

de la Cueva-Mendez, G., Labib, K.

Principal Investigator(s):
Karim Labib
2008
PubMed

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

Zagorska, A., Pozo-Guisado, E., Boudeau, J., Vitari, A. C., Rafiqi, F. H., Thastrup, J., Deak, M., Campbell, D. G., Morrice, N. A., Prescott, A. R., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2007
PubMed

Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide

Windheim, M., Lang, C., Peggie, M., Plater, L. A., Cohen, P.

Principal Investigator(s):
Philip Cohen
2007
PubMed

Structural insights into the recognition of substrates and activators by the OSR1 kinase

Villa, F., Goebel, J., Rafiqi, F. H., Deak, M., Thastrup, J., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):
Dario Alessi
2007
PubMed

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

Sapkota, G. P., Cummings, L., Newell, F. S., Armstrong, C., Bain, J., Frodin, M., Grauert, M., Hoffmann, M., Schnapp, G., Steegmaier, M., Cohen, P., Alessi, D. R.

Principal Investigator(s):
Dario Alessi, Philip Cohen, Gopal Sapkota
2007
PubMed

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Pearce, L. R., Huang, X., Boudeau, J., Pawlowski, R., Wullschleger, S., Deak, M., Ibrahim, A. F., Gourlay, R., Magnuson, M. A., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2007
PubMed

Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage

Munoz, I. M., Jowsey, P. A., Toth, R., Rouse, J.

Principal Investigator(s):
John Rouse
2007
PubMed

Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

Logie, L., Ruiz-Alcaraz, A. J., Keane, M., Woods, Y. L., Bain, J., Marquez, R., Alessi, D. R., Sutherland, C.

Principal Investigator(s):
Dario Alessi
2007
PubMed

Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR

Jowsey, P., Morrice, N. A., Hastie, C. J., McLauchlan, H., Toth, R., Rouse, J.

Principal Investigator(s):
John Rouse
2007

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

Jaleel, M., Nichols, R. J., Deak, M., Campbell, D. G., Gillardon, F., Knebel, A., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2007
PubMed