Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis

Cuadrado, A., Lafarga, V., Cheung, P. C. F., Dolado, I., Llanos, S., Cohen, P., Nebreda, A. R.

Principal Investigator(s):

Dario Alessi, Philip Cohen

2007

The selectivity of protein kinase inhibitors: a further update

Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., McLauchlan, H., Klevernic, I., Arthur, J. S., Alessi, D. R., Cohen, P.

Principal Investigator(s):

2007

Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis

Arbiser, J. L., Kau, T., Konar, M., Narra, K., Ramchandran, R., Summers, S. A., Vlahos, C. J., Ye, K. Q., Perry, B. N., Matter, W., Fischl, A., Cook, J., Silver, P. A., Bain, J., Cohen, P., Whitmire, D., Furness, S., Govindarajan, B., Bowen, J. P.

Principal Investigator(s):

2007

Protein Phosphorylation

Alessi, D. R., Zeqiraj, E.

Principal Investigator(s):

2007

Balancing BMP signaling through integrated inputs into the Smad1 linker

Sapkota, G., Alarcon, C., Spagnoli, F. M., Brivanlou, A. H., Massague, J.

Principal Investigator(s):

Gopal Sapkota

2007

Replication fork barriers: pausing for a break or stalling for time?

Labib, K., Hodgson, B.

Principal Investigator(s):

2007

A key role for the GINS complex at DNA replication forks

Labib, K., Gambus, A.

Principal Investigator(s):

2007

Highlights of the 23rd Genes and Cancer meeting University of Warwick 11-13 December 2006

Labib, K.

Principal Investigator(s):

2007

Mrc1 and Tof1 regulate DNA replication forks in different ways during normal S phase

Hodgson, B., Calzada, A., Labib, K.

Principal Investigator(s):

2007

Prediction of solvation sites at the interface of Src SH2 domain complexes using molecular dynamics simulations

Geroult, S., Hooda, M., Virdee, S., Waksman, G.

Principal Investigator(s):

Satpal Virdee

2007

A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling

Findlay, G. M., Yan, L., Procter, J., Mieulet, V., Lamb, R. F.

Principal Investigator(s):

Greg Findlay

2007

Foreword - The origins of GSK-3

Cohen, P.

Principal Investigator(s):

2006

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

Vitari, A. C., Thastrup, J., Rafiqi, F. H., Deak, M., Morrice, N. A., Karlsson, H. K., Alessi, D. R.

Principal Investigator(s):

2006

Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62

Stafford, M. J., Morrice, N. A., Peggie, M. W., Cohen, P.

Principal Investigator(s):

2006

Impaired intestinal NHE3 activity in the PDK1 hypomorphic mouse

Sandu, C., Artunc, F., Palmada, M., Rexhepaj, R., Grahammer, F., Hussain, A., Yun, C., Alessi, D. R., Lang, F.

Principal Investigator(s):

2006

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1

Sakamoto, K., Zarrinpashneh, E., Budas, G. R., Pouleur, A. C., Dutta, A., Prescott, A. R., Vanoverschelde, J. L., Ashworth, A., Jovanovic, A., Alessi, D. R., Bertrand, L.

Principal Investigator(s):

2006

CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway

Rousseau, S., Dolado, I., Beardmore, V., Shpiro, N., Marquez, R., Nebreda, A. R., Arthur, J. S., Case, L. M., Tessier-Lavigne, M., Gaestel, M., Cuenda, A., Cohen, P.

Principal Investigator(s):

2006

Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice

Rexhepaj, R., Grahammer, F., Volkl, H., Remy, C., Wagner, C. A., Sandulache, D., Artunc, F., Henke, G., Nammi, S., Capasso, G., Alessi, D. R., Lang, F.

Principal Investigator(s):

2006

Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ

Morton, S., Yang, H. T., Moleleki, N., Campbell, D. G., Cohen, P., Rousseau, S.

Principal Investigator(s):

2006