Research | Publications

Year

Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway

Hodson, C., Cole, A. R., Lewis, L. P., Miles, J. A., Purkiss, A., Walden, H.

2011
PubMed

Thapsigargin distinguishes membrane fusion in the late stages of endocytosis and autophagy

Ganley, I. G., Wong, P. M., Jiang, X.

Principal Investigator(s):
Ian Ganley
2011
PubMed

Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest

Ganley, I. G., Wong, P. M., Gammoh, N., Jiang, X.

Principal Investigator(s):
Ian Ganley
2011
PubMed

Autoregulation of Parkin activity through its ubiquitin-like domain

Chaugule, V. K., Burchell, L., Barber, K. R., Sidhu, A., Leslie, S. J., Shaw, G. S., Walden, H.

2011
PubMed

Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

Akutsu, M., Ye, Y., Virdee, S., Chin, J. W., Komander, D.

Principal Investigator(s):
Satpal Virdee
2011
PubMed

The structure of FANCL, the catalytic subunit of the Fanconi Anemia core complex

Cole, AR., Lewis, LPC, Walden, H

2010
PubMed

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion

Zagorska, A., Deak, M., Campbell, D. G., Banerjee, S., Hirano, M., Aizawa, S., Prescott, A. R., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2010
PubMed

PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR

Yan, L., Mieulet, V., Burgess, D., Findlay, G. M., Sully, K., Procter, J., Goris, J., Janssens, V., Morrice, N. A., Lamb, R. F.

Principal Investigator(s):
Greg Findlay
2010
PubMed

Mec1/Tel1-dependent phosphorylation of Slx4 stimulates Rad1-Rad10-dependent cleavage of non-homologous DNA tails

Toh, G. W., Sugawara, N., Dong, J., Toth, R., Lee, S. E., Haber, J. E., Rouse, J.

Principal Investigator(s):
John Rouse
2010
PubMed

Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation

Sanchez Canedo, C., Demeulder, B., Ginion, A., Bayascas, J. R., Balligand, J. L., Alessi, D. R., Vanoverschelde, J. L., Beauloye, C., Hue, L., Bertrand, L.

Principal Investigator(s):
Dario Alessi
2010
PubMed

SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2

Reiche, J., Theilig, F., Rafiqi, F. H., Carlo, A. S., Militz, D., Mutig, K., Todiras, M., Christensen, E. I., Ellison, D. H., Bader, M., Nykjaer, A., Bachmann, S., Alessi, D., Willnow, T. E.

Principal Investigator(s):
Dario Alessi
2010
PubMed

Role of the WNK-activated SPAK kinase in regulating blood pressure

Rafiqi, F. H., Zuber, A. M., Glover, M., Richardson, C., Fleming, S., Jovanovic, S., Jovanovic, A., O'Shaughnessy, K. M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2010
PubMed

Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry

Pozo-Guisado, E., Campbell, D. G., Deak, M., Alvarez-Barrientos, A., Morrice, N. A., Alvarez, I. S., Alessi, D. R., Martin-Romero, F. J.

Principal Investigator(s):
Dario Alessi
2010
PubMed

The nuts and bolts of AGC protein kinases

Pearce, L. R., Komander, D., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2010
PubMed

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

Pearce, L. R., Alton, G. R., Richter, D. T., Kath, J. C., Lingardo, L., Chapman, J., Hwang, C., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2010
PubMed

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

Nichols, R. J., Dzamko, N., Morrice, N. A., Campbell, D. G., Deak, M., Ordureau, A., Macartney, T., Tong, Y., Shen, J., Prescott, A. R., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2010
PubMed

Uncoupling the Warburg effect from cancer

Najafov, A., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2010
PubMed

Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

Mackay, C., Declais, A. C., Lundin, C., Agostinho, A., Deans, A. J., Macartney, T. J., Hofmann, K., Gartner, A., West, S. C., Helleday, T., Lilley, D. M., Rouse, J.

Principal Investigator(s):
John Rouse
2010
PubMed

Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells

Finlay, D. K., Kelly, A. P., Clarke, R., Sinclair, L. V., Deak, M., Alessi, D. R., Cantrell, D. A.

Principal Investigator(s):
Dario Alessi
2010
PubMed

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

Dzamko, N., Deak, M., Hentati, F., Reith, A. D., Prescott, A. R., Alessi, D. R., Nichols, R. J.

Principal Investigator(s):
Dario Alessi
2010
PubMed