Research | Publications

Year

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

Najafov, A., Sommer, E. M., Axten, J. M., Deyoung, M. P., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2011
PubMed

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop

Loffler, A. S., Alers, S., Dieterle, A. M., Keppeler, H., Franz-Wachtel, M., Kundu, M., Campbell, D. G., Wesselborg, S., Alessi, D. R., Stork, B.

Principal Investigator(s):
Dario Alessi
2011
PubMed

Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon {beta}

Gleason, C. E., Ordureau, A., Gourlay, R., Arthur, J. S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2011
PubMed

Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice

Garcia-Martinez, J. M., Wullschleger, S., Preston, G., Guichard, S., Fleming, S., Alessi, D. R., Duce, S. L.

Principal Investigator(s):
Dario Alessi
2011
PubMed

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

Filippi, B. M., de Los Heros, P., Mehellou, Y., Navratilova, I., Gourlay, R., Deak, M., Plater, L., Toth, R., Zeqiraj, E., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2011
PubMed

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

Deng, X., Dzamko, N., Prescott, A., Davies, P., Liu, Q., Yang, Q., Lee, J. D., Patricelli, M. P., Nomanbhoy, T. K., Alessi, D. R., Gray, N. S.

Principal Investigator(s):
Dario Alessi
2011
PubMed

The TRAF-associated protein TANK facilitates cross-talk within the I{kappa}B kinase family during Toll-like receptor signaling

Clark, K., Takeuchi, O., Akira, S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2011
PubMed

Novel cross-talk within the IKK family controls innate immunity

Clark, K., Peggie, M., Plater, L., Sorcek, R. J., Young, E. R., Madwed, J. B., Hough, J., McIver, E. G., Cohen, P.

Principal Investigator(s):
Philip Cohen
2011
PubMed

Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade

Chiga, M., Rafiqi, F. H., Alessi, D. R., Sohara, E., Ohta, A., Rai, T., Sasaki, S., Uchida, S.

Principal Investigator(s):
Dario Alessi
2011
PubMed

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2011
PubMed

Traceless and site-specific ubiquitination of recombinant proteins

Virdee, S., Kapadnis, P. B., Elliott, T., Lang, K., Madrzak, J., Nguyen, D. P., Riechmann, L., Chin, J. W.

Principal Investigator(s):
Satpal Virdee
2011
PubMed

RUTBC1 Protein, a Rab9A Effector That Activates GTP Hydrolysis by Rab32 and Rab33B Proteins

Nottingham, R. M., Ganley, I. G., Barr, F. A., Lambright, D. G., Pfeffer, S. R.

Principal Investigator(s):
Ian Ganley
2011
PubMed

Hydrophobic, aromatic, and electrostatic interactions play a central role in amyloid fibril formation and stability

Marshall, K. E., Morris, K. L., Charlton, D., O'Reilly, N., Lewis, L., Walden, H., Serpell, L. C.

Principal Investigator(s):
Helen Walden
2011
PubMed

Surviving chromosome replication: the many roles of the S-phase checkpoint pathway

Labib, K., De Piccoli, G.

Principal Investigator(s):
Karim Labib
2011
PubMed

Building a double hexamer of DNA helicase at eukaryotic replication origins

Labib, K.

Principal Investigator(s):
Karim Labib
2011
PubMed

Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway

Hodson, C., Cole, A. R., Lewis, L. P., Miles, J. A., Purkiss, A., Walden, H.

Principal Investigator(s):
Helen Walden
2011
PubMed

Thapsigargin distinguishes membrane fusion in the late stages of endocytosis and autophagy

Ganley, I. G., Wong, P. M., Jiang, X.

Principal Investigator(s):
Ian Ganley
2011
PubMed

Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest

Ganley, I. G., Wong, P. M., Gammoh, N., Jiang, X.

Principal Investigator(s):
Ian Ganley
2011
PubMed

Autoregulation of Parkin activity through its ubiquitin-like domain

Chaugule, V. K., Burchell, L., Barber, K. R., Sidhu, A., Leslie, S. J., Shaw, G. S., Walden, H.

Principal Investigator(s):
Helen Walden
2011
PubMed

Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

Akutsu, M., Ye, Y., Virdee, S., Chin, J. W., Komander, D.

Principal Investigator(s):
Satpal Virdee
2011
PubMed