Researchers of the laboratories of Matthias Trost in the MRC Protein Phosphorylation Unit and Patrick Pedrioli in SCILLS have developed, in collaboration with Thermo-Fisher Scientific, a novel strong-anion exchange chromatography improving current technology for the identification of complex proteomes. Lead author Stella Ritorto shows in a publication in Journal of Proteome Research that this novel fractionation technique allows a deep analysis of the proteome with almost 10,000 proteins identified in macrophage cell lysate. This deep-proteome analysis will allow researchers in the future to identify and quantify low-abundant proteins which are notoriously difficult to analyse. This exciting new technology is already being applied in several projects in the Unit focussing on phosphorylation and ubiquitylation pathways in Parkinson's disease and cancer providing new insights into molecular pathways affected by these diseases.