Research | Publications

Year

The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL

Miles, J. A., Frost, M. G., Carroll, E., Rowe, M. L., Howard, M. J., Sidhu, A., Chaugule, V. K., Alpi, A. F., Walden, H.

2015
PubMed

Suppression of Interferon beta gene transcription by inhibitors of Bromodomain and Extra-Terminal (BET) family members

Malik, N., Vollmer, S., Nanda, S. K., Lopez-Pelaez, M., Prescott, A., Gray, N., Cohen, P.

Principal Investigator(s):
Philip Cohen
2015
PubMed

Tethering of SCF(Dia2) to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase

Maculins, T., Nkosi, P. J., Nishikawa, H., Labib, K.

Principal Investigator(s):
Karim Labib
2015
PubMed

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

Lai, Y. C., Kondapalli, C., Lehneck, R., Procter, J. B., Dill, B. D., Woodroof, H. I., Gourlay, R., Peggie, M., Macartney, T. J., Corti, O., Corvol, J. C., Campbell, D. G., Itzen, A., Trost, M., Muqit, M. M.

Principal Investigator(s):
Miratul Muqit
2015
PubMed

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

Kumar, A., Aguirre, J. D., Condos, T. E., Martinez-Torres, R. J., Chaugule, V. K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D. E., Barber, K. R., Shaw, G. S., Walden, H.

2015
PubMed

Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations

Kristariyanto, Y. A., Choi, S. Y., Rehman, S. A., Ritorto, M. S., Campbell, D. G., Morrice, N. A., Toth, R., Kulathu, Y.

Principal Investigator(s):
Yogesh Kulathu
2015
PubMed

K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin

Kristariyanto, Y. A., Abdul Rehman, S. A., Campbell, D. G., Morrice, N. A., Johnson, C., Toth, R., Kulathu, Y.

Principal Investigator(s):
Yogesh Kulathu
2015
PubMed

PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease

Kazlauskaite, A., Muqit, M. M.

Principal Investigator(s):
Miratul Muqit
2015
PubMed

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

Kazlauskaite, A., Martinez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H., Muqit, M. M.

Principal Investigator(s):
Dario Alessi, Miratul Muqit
2015
PubMed

Photoactivatable Prodrugs of Antimelanoma Agent Vemurafenib

Horbert, R., Pinchuk, B., Davies, P., Alessi, D., Peifer, C.

Principal Investigator(s):
Dario Alessi
2015
PubMed

Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization

Herhaus, L., Perez-Oliva, A. B., Cozza, G., Gourlay, R., Weidlich, S., Campbell, D. G., Pinna, L. A., Sapkota, G. P.

Principal Investigator(s):
Gopal Sapkota
2015
PubMed

Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor

Hatcher, J. M., Zhang, J., Choi, H. G., Ito, G., Alessi, D. R., Gray, N. S.

Principal Investigator(s):
Dario Alessi
2015
PubMed

A Versatile Strategy for the Semisynthetic Production of Ser65 Phosphorylated Ubiquitin and Its Biochemical and Structural Characterisation

Han, C., Pao, K. C., Kazlauskaite, A., Muqit, M. M., Virdee, S.

Principal Investigator(s):
Miratul Muqit, Satpal Virdee
2015
PubMed

Structural Characterization of LRRK2 Inhibitors

Gilsbach, B. K., Messias, A. C., Ito, G., Sattler, M., Alessi, D. R., Wittinghofer, A., Kortholt, A.

Principal Investigator(s):
Dario Alessi
2015
PubMed

A conserved Pol binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1

Garcia-Rodriguez, L. J., De Piccoli, G., Marchesi, V., Jones, R. C., Edmondson, R. D., Labib, K.

Principal Investigator(s):
Karim Labib
2015
PubMed

Optimising methods for the preservation, capture and identification of ubiquitin chains and ubiquitylated proteins by immunoblotting

Emmerich, C. H., Cohen, P.

Principal Investigator(s):
Philip Cohen
2015
PubMed

Bill Whelan's impact on my life and career

Cohen, P.

Principal Investigator(s):
Philip Cohen
2015
PubMed

Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

Bett, J. S., Ritorto, M. S., Ewan, R., Jaffray, E. G., Virdee, S., Chin, J. W., Knebel, A., Kurz, T., Trost, M., Tatham, M. H., Hay, R. T.

Principal Investigator(s):
Satpal Virdee
2015
PubMed

The promise and peril of chemical probes

Arrowsmith, C. H. , Audia, J. E., et al including Cohen, P.

Principal Investigator(s):
Philip Cohen
2015
PubMed

An important role for A20-binding inhibitor of nuclear factor-kB-1 (ABIN1) in inflammation-mediated endothelial dysfunction: an in vivo study in ABIN1 (D485N) mice

Akbar, N., Nanda, S., Belch, J., Cohen, P., Khan, F.

Principal Investigator(s):
Philip Cohen
2015
PubMed