Research | Publications

Year

TRAF4, a multifaceted protein involved in carcinoma progression

Adrien Rousseau, Léa P Wilhelm, Catherine Tomasetto and Fabien Alpy

Principal Investigator(s):
Adrien Rousseau
2014
PubMed

The phosphoinositide-binding protein TRAF4 modulates tight junction stability and migration of cancer cells

Adrien Rousseau, Catherine Tomasetto and Fabien Alpy

Principal Investigator(s):
Adrien Rousseau
2014
PubMed

An inducible chaperone adapts proteasome assembly to stress

Ariane Hanssum, Zhen Zhong, Adrien Rousseau, Agnieszka Krzyzosiak, Anna Sigurdardottir and Anne Bertolotti

Principal Investigator(s):
Adrien Rousseau
2014
PubMed

An unexpected twist to the activation of IKKbeta: TAK1 primes IKKbeta for activation by autophosphorylation

Zhang, J., Clark, K., Lawrence, T., Peggie, M. W., Cohen, P.

Principal Investigator(s):
Philip Cohen
2014
PubMed

The fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder

Walden, H., Deans, A. J.

2014
PubMed

Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling

Vogt, J., Dingwell, K. S., Herhaus, L., Gourlay, R., Macartney, T., Campbell, D., Smith, J. C., Sapkota, G. P.

Principal Investigator(s):
Gopal Sapkota
2014
PubMed

Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

van der Wijst, J., Blanchard, M. G., Woodroof, H. I., Macartney, T. J., Gourlay, R., Hoenderop, J. G., Bindels, R. J., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2014
PubMed

RBR E3 ubiquitin ligases: new structures, new insights, new questions

Spratt, D. E., Walden, H., Shaw, G. S.

2014
PubMed

A Ctf4 trimer couples the CMG helicase to DNA polymerase alpha in the eukaryotic replisome

Simon, A. C., Zhou, J. C., Perera, R. L., van Deursen, F., Evrin, C., Ivanova, M. E., Kilkenny, M. L., Renault, L., Kjaer, S., Matak-Vinkovic, D., Labib, K., Costa, A., Pellegrini, L.

Principal Investigator(s):
Karim Labib
2014
PubMed

Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation

Schumacher, F. R., Sorrell, F. J., Alessi, D. R., Bullock, A. N., Kurz, T.

Principal Investigator(s):
Dario Alessi
2014
PubMed

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

Schonhuber, N., Seidler, B., Schuck, K., Veltkamp, C., Schachtler, C., Zukowska, M., Eser, S., Feyerabend, T. B., Paul, M. C., Eser, P., Klein, S., Lowy, A. M., Banerjee, R., Yang, F., Lee, C. L., Moding, E. J., Kirsch, D. G., Scheideler, A., Alessi, D. R., Varela, I., Bradl

Principal Investigator(s):
Dario Alessi
2014
PubMed

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

Ritorto, M. S., Ewan, R., Perez-Oliva, A. B., Knebel, A., Buhrlage, S. J., Wightman, M., Kelly, S. M., Wood, N. T., Virdee, S., Gray, N. S., Morrice, N. A., Alessi, D. R., Trost, M.

Principal Investigator(s):
Dario Alessi, Satpal Virdee
2014
PubMed

FAN1 Activity on Asymmetric Repair Intermediates Is Mediated by an Atypical Monomeric Virus-type Replication-Repair Nuclease Domain

Pennell, S., Declais, A. C., Li, J., Haire, L. F., Berg, W., Saldanha, J. W., Taylor, I. A., Rouse, J., Lilley, D. M., Smerdon, S. J.

Principal Investigator(s):
John Rouse
2014
PubMed

Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein

Nair, N., Castor, D., Macartney, T., Rouse, J.

Principal Investigator(s):
John Rouse
2014
PubMed

Improved Genome Editing in Human Cell Lines Using the CRISPR Method

Munoz, I. M., Szyniarowski, P., Toth, R., Rouse, J., Lachaud, C.

Principal Investigator(s):
John Rouse
2014
PubMed

Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

Maric, M., Maculins, T., De Piccoli, G., Labib, K.

Principal Investigator(s):
Karim Labib
2014
PubMed

Protein kinase IKKbeta-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells

Lopez-Pelaez, M., Lamont, D. J., Peggie, M., Shpiro, N., Gray, N. S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2014
PubMed

IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation

Lin, K. M., Hu, W., Troutman, T. D., Jennings, M., Brewer, T., Li, X., Nanda, S., Cohen, P., Thomas, J. A., Pasare, C.

Principal Investigator(s):
Philip Cohen
2014
PubMed

Distinct functional roles for the two SLX4 ubiquitin-binding UBZ domains mutated in Fanconi anemia

Lachaud, C., Castor, D., Hain, K., Munoz, I., Wilson, J., MacArtney, T. J., Schindler, D., Rouse, J.

Principal Investigator(s):
John Rouse
2014
PubMed

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

Kazlauskaite, A., Kondapalli, C., Gourlay, R., Campbell, D. G., Ritorto, M. S., Hofmann, K., Alessi, D. R., Knebel, A., Trost, M., Muqit, M. M.

Principal Investigator(s):
Dario Alessi, Miratul Muqit
2014
PubMed