Research | Publications

Year

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo

Oi, K., Sohara, E., Rai, T., Misawa, M., Chiga, M., Alessi, D. R., Sasaki, S., Uchida, S.

Principal Investigator(s):
Dario Alessi
2012
PubMed

Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Activates the WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice

Nishida, H., Sohara, E., Nomura, N., Chiga, M., Alessi, D. R., Rai, T., Sasaki, S., Uchida, S.

Principal Investigator(s):
Dario Alessi
2012
PubMed

Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors

Najafov, A., Shpiro, N., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2012
PubMed

Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex

Munoz, I. M., Macartney, T., Sanchez-Pulido, L., Ponting, C. P., Rocha, S., Rouse, J.

Principal Investigator(s):
John Rouse
2012
PubMed

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKepsilon kinases

McIver, E. G., Bryans, J., Birchall, K., Chugh, J., Drake, T., Lewis, S. J., Osborne, J., Smiljanic-Hurley, E., Tsang, W., Kamal, A., Levy, A., Newman, M., Taylor, D., Arthur, J. S., Clark, K., Cohen, P.

Principal Investigator(s):
Philip Cohen
2012
PubMed

Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease1

Lewis, P. A., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2012
PubMed

Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production

Landego, I., Jayachandran, N., Wullschleger, S., Zhang, T. T., Gibson, I. W., Miller, A., Alessi, D. R., Marshall, A. J.

Principal Investigator(s):
Dario Alessi
2012
PubMed

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

Kondapalli, C., Kazlauskaite, A., Zhang, N., Woodroof, H. I., Campbell, D. G., Gourlay, R., Burchell, L., Walden, H., Macartney, T. J., Deak, M., Knebel, A., Alessi, D. R., Muqit, M. M.

Principal Investigator(s):
Dario Alessi, Miratul Muqit
2012
PubMed

Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

Goh, E. T., Arthur, J. S., Cheung, P. C., Akira, S., Toth, R., Cohen, P.

Principal Investigator(s):
Philip Cohen
2012
PubMed

PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha(12)

Gan, X., Wang, J., Wang, C., Sommer, E., Kozasa, T., Srinivasula, S., Alessi, D., Offermanns, S., Simon, M. I., Wu, D.

Principal Investigator(s):
Dario Alessi
2012
PubMed

Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA

Enesa, K., Ordureau, A., Smith, H., Barford, D., Cheung, P. C., Patterson-Kane, J., Arthur, J. S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2012
PubMed

The IkappaB Kinase Family Phosphorylates the Parkinson's Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

Dzamko, N., Inesta-Vaquera, F., Zhang, J., Xie, C., Cai, H., Arthur, S., Tan, L., Choi, H., Gray, N., Cohen, P., Pedrioli, P., Clark, K., Alessi, D. R.

Principal Investigator(s):
Dario Alessi, Philip Cohen
2012
PubMed

Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells

Din, F. V., Valanciute, A., Houde, V. P., Zibrova, D., Green, K. A., Sakamoto, K., Alessi, D. R., Dunlop, M. G.

Principal Investigator(s):
Dario Alessi
2012
PubMed

DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage

Davis, E. J., Lachaud, C., Appleton, P., Macartney, T. J., Nathke, I., Rouse, J.

Principal Investigator(s):
John Rouse
2012
PubMed

Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

Clark, K., MacKenzie, K. F., Petkevicius, K., Kristariyanto, Y., Zhang, J., Choi, H. G., Peggie, M., Plater, L., Pedrioli, P. G., McIver, E., Gray, N. S., Arthur, J. S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2012
PubMed

Brain Penetrant LRRK2 Inhibitor

Choi, H. G., Zhang, J., Deng, X., Hatcher, J. M., Patricelli, M. P., Zhao, Z., Alessi, D. R., Gray, N. S.

Principal Investigator(s):
Dario Alessi
2012
PubMed

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

Castaneda-Bueno, M., Cervantes-Perez, L. G., Vazquez, N., Uribe, N., Kantesaria, S., Morla, L., Bobadilla, N. A., Doucet, A., Alessi, D. R., Gamba, G.

Principal Investigator(s):
Dario Alessi
2012
PubMed

Phosphatases in SMAD regulation

Bruce, D. L., Sapkota, G. P.

Principal Investigator(s):
Gopal Sapkota
2012
PubMed

Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway

Bruce, D. L., Macartney, T., Yong, W., Shou, W., Sapkota, G. P.

Principal Investigator(s):
Gopal Sapkota
2012
PubMed

Phenformin as prophylaxis and therapy in breast cancer xenografts

Appleyard, M. V., Murray, K. E., Coates, P. J., Wullschleger, S., Bray, S. E., Kernohan, N. M., Fleming, S., Alessi, D. R., Thompson, A. M.

Principal Investigator(s):
Dario Alessi
2012
PubMed