Research | Publications

Year

Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells

Finlay, D. K., Kelly, A. P., Clarke, R., Sinclair, L. V., Deak, M., Alessi, D. R., Cantrell, D. A.

Principal Investigator(s):
Dario Alessi
2010
PubMed

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

Dzamko, N., Deak, M., Hentati, F., Reith, A. D., Prescott, A. R., Alessi, D. R., Nichols, R. J.

Principal Investigator(s):
Dario Alessi
2010
PubMed

Identification of the MMS22L-TONSL complex that promotes homologous recombination

Duro, E., Lundin, C., Ask, K., Sanchez-Pulido, L., MacArtney, T. J., Toth, R., Ponting, C. P., Groth, A., Helleday, T., Rouse, J.

Principal Investigator(s):
John Rouse
2010
PubMed

Will the ubiquitin system furnish as many drug targets as protein kinases?

Cohen, P., Tcherpakov, M.

Principal Investigator(s):
Philip Cohen
2010
PubMed

Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

Cohen, P.

Principal Investigator(s):
Philip Cohen
2010
PubMed

Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles

Akue-Gedu, R., Nauton, L., Thery, V., Bain, J., Cohen, P., Anizon, F., Moreau, P.

Principal Investigator(s):
Philip Cohen
2010
PubMed

Selenium incorporation using recombinant techniques

Walden, H.

2010
PubMed

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

Virdee, S., Ye, Y., Nguyen, D. P., Komander, D., Chin, J. W.

Principal Investigator(s):
Satpal Virdee
2010
PubMed

Semisynthetic Src SH2 domains demonstrate altered phosphopeptide specificity induced by incorporation of unnatural lysine derivatives

Virdee, S., Macmillan, D., Waksman, G.

Principal Investigator(s):
Satpal Virdee
2010
PubMed

Ubiquitin signalling in DNA replication and repair

Ulrich, H. D., Walden, H.

2010
PubMed

Genetically directing varepsilon-N, N-dimethyl-L-lysine in recombinant histones

Nguyen, D. P., Garcia Alai, M. M., Virdee, S., Chin, J. W.

Principal Investigator(s):
Satpal Virdee
2010
PubMed

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

Labib, K.

Principal Investigator(s):
Karim Labib
2010
PubMed

The structure of the catalytic subunit FANCL of the Fanconi anemia core complex

Cole, A. R., Lewis, L. P., Walden, H.

2010
PubMed

ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor

Zeqiraj, E., Filippi, B. M., Goldie, S., Navratilova, I., Boudeau, J., Deak, M., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):
Dario Alessi
2009
PubMed

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

Zeqiraj, E., Filippi, B. M., Deak, M., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):
Dario Alessi
2009
PubMed

DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins

Yang, H. T., Peggie, M., Cohen, P., Rousseau, S.

Principal Investigator(s):
Philip Cohen
2009
PubMed

Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4

Smith, H., Peggie, M., Campbell, D. G., Vandermoere, F., Carrick, E., Cohen, P.

Principal Investigator(s):
Philip Cohen
2009
PubMed

Characterisation of a novel NR4A2 mutation in Parkinson's disease brain

Sleiman, P. M., Healy, D. G., Muqit, M. M., Yang, Y. X., Van Der Brug, M., Holton, J. L., Revesz, T., Quinn, N. P., Bhatia, K., Diss, J. K., Lees, A. J., Cookson, M. R., Latchman, D. S., Wood, N. W.

Principal Investigator(s):
Miratul Muqit
2009
PubMed

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

San-Cristobal, P., Pacheco-Alvarez, D., Richardson, C., Ring, A. M., Vazquez, N., Rafiqi, F. H., Chari, D., Kahle, K. T., Leng, Q., Bobadilla, N. A., Hebert, S. C., Alessi, D. R., Lifton, R. P., Gamba, G.

Principal Investigator(s):
Dario Alessi
2009
PubMed

Control of genome stability by SLX protein complexes

Rouse, J.

Principal Investigator(s):
John Rouse
2009
PubMed