Research | Publications

Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide

Windheim, M., Lang, C., Peggie, M., Plater, L. A., Cohen, P.

Principal Investigator(s):

Philip Cohen

2007

PubMed

Structural insights into the recognition of substrates and activators by the OSR1 kinase

Villa, F., Goebel, J., Rafiqi, F. H., Deak, M., Thastrup, J., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):

Dario Alessi

2007

PubMed

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

Sapkota, G. P., Cummings, L., Newell, F. S., Armstrong, C., Bain, J., Frodin, M., Grauert, M., Hoffmann, M., Schnapp, G., Steegmaier, M., Cohen, P., Alessi, D. R.

Principal Investigator(s):

Dario Alessi, Philip Cohen, Gopal Sapkota

2007

PubMed

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Pearce, L. R., Huang, X., Boudeau, J., Pawlowski, R., Wullschleger, S., Deak, M., Ibrahim, A. F., Gourlay, R., Magnuson, M. A., Alessi, D. R.

Principal Investigator(s):

Dario Alessi

2007

PubMed

Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage

Munoz, I. M., Jowsey, P. A., Toth, R., Rouse, J.

Principal Investigator(s):

John Rouse

2007

PubMed

Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

Logie, L., Ruiz-Alcaraz, A. J., Keane, M., Woods, Y. L., Bain, J., Marquez, R., Alessi, D. R., Sutherland, C.

Principal Investigator(s):

Dario Alessi

2007

PubMed

Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR

Jowsey, P., Morrice, N. A., Hastie, C. J., McLauchlan, H., Toth, R., Rouse, J.

Principal Investigator(s):

John Rouse

2007

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

Jaleel, M., Nichols, R. J., Deak, M., Campbell, D. G., Gillardon, F., Knebel, A., Alessi, D. R.

Principal Investigator(s):

Dario Alessi

2007

PubMed

Phosphorylation of Slx4 by Mec1 and Tel1 regulates the single-strand annealing mode of DNA repair in budding yeast

Flott, S., Alabert, C., Toh, G. W., Toth, R., Sugawara, N., Campbell, D. G., Haber, J. E., Pasero, P., Rouse, J.

Principal Investigator(s):

John Rouse

2007

PubMed

A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis

Cuadrado, A., Lafarga, V., Cheung, P. C. F., Dolado, I., Llanos, S., Cohen, P., Nebreda, A. R.

Principal Investigator(s):

Philip Cohen

2007

The selectivity of protein kinase inhibitors: a further update

Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., McLauchlan, H., Klevernic, I., Arthur, J. S., Alessi, D. R., Cohen, P.

Principal Investigator(s):

Dario Alessi, Philip Cohen

2007

PubMed

Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis

Arbiser, J. L., Kau, T., Konar, M., Narra, K., Ramchandran, R., Summers, S. A., Vlahos, C. J., Ye, K. Q., Perry, B. N., Matter, W., Fischl, A., Cook, J., Silver, P. A., Bain, J., Cohen, P., Whitmire, D., Furness, S., Govindarajan, B., Bowen, J. P.

Principal Investigator(s):

Philip Cohen

2007