Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

2008

Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

Morton, S., Hesson, L., Peggie, M., Cohen, P.

Principal Investigator(s):

2008

Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

Mendoza, H., Campbell, D. G., Burness, K., Hastie, J., Ronkina, N., Shim, J. H., Arthur, J. S., Davis, R. J., Gaestel, M., Johnson, G. L., Ghosh, S., Cohen, P.

Principal Investigator(s):

2008

Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer

McCracken, S. R., Ramsay, A., Heer, R., Mathers, M. E., Jenkins, B. L., Edwards, J., Robson, C. N., Marquez, R., Cohen, P., Leung, H. Y.

Principal Investigator(s):

2008

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

Huang, X., Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., McBurnie, W., Fleming, S., Alessi, D. R.

Principal Investigator(s):

2008

Use of Akt Inhibitor and a Drug-resistant Mutant Validates a Critical Role for Protein Kinase B/Akt in the Insulin-dependent Regulation of Glucose and System A Amino Acid Uptake

Green, C. J., Goransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, K., Hundal, H. S.

Principal Investigator(s):

2008

PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage

Gohler, T., Munoz, I. M., Rouse, J., Blow, J. J.

Principal Investigator(s):

John Rouse

2008

Identification and characterization of FUS/TLS as a new target of ATM

Gardiner, M., Toth, R., Vandermoere, F., Morrice, N. A., Rouse, J.

Principal Investigator(s):

John Rouse

2008

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Garcia-Martinez, J. M., Alessi, D. R.

Principal Investigator(s):

2008

Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters

Filippi, B. M., Alessi, D. R.

Principal Investigator(s):

2008

Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage

Duro, E., Vaisica, J. A., Brown, G. W., Rouse, J.

Principal Investigator(s):

John Rouse

2008

Lithium prevents and ameliorates experimental autoimmune encephalomyelitis

De Sarno, P., Axtell, R. C., Raman, C., Roth, K. A., Alessi, D. R., Jope, R. S.

Principal Investigator(s):

2008

p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation

Cuomo, M. E., Knebel, A., Morrice, N., Paterson, H., Cohen, P., Mittnacht, S.

Principal Investigator(s):

2008

PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response

Belgardt, B. F., Husch, A., Rother, E., Ernst, M. B., Wunderlich, F. T., Hampel, B., Klockener, T., Alessi, D., Kloppenburg, P., Bruning, J. C.

Principal Investigator(s):

2008

Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

Bayascas, J. R., Wullschleger, S., Sakamoto, K., Garcia-Martinez, J. M., Clacher, C., Komander, D., van Aalten, D. M., Boini, K. M., Lang, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., van Diepen, J. A., Voshol, P. J., Lucocq, J. M., Alessi, D. R.

Principal Investigator(s):

2008