Research | Publications

Year

Use of Akt Inhibitor and a Drug-resistant Mutant Validates a Critical Role for Protein Kinase B/Akt in the Insulin-dependent Regulation of Glucose and System A Amino Acid Uptake

Green, C. J., Goransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, K., Hundal, H. S.

Principal Investigator(s):
Dario Alessi
2008
PubMed

PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage

Gohler, T., Munoz, I. M., Rouse, J., Blow, J. J.

Principal Investigator(s):
John Rouse
2008
PubMed

Identification and characterization of FUS/TLS as a new target of ATM

Gardiner, M., Toth, R., Vandermoere, F., Morrice, N. A., Rouse, J.

Principal Investigator(s):
John Rouse
2008
PubMed

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Garcia-Martinez, J. M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2008
PubMed

Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters

Filippi, B. M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2008
PubMed

Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage

Duro, E., Vaisica, J. A., Brown, G. W., Rouse, J.

Principal Investigator(s):
John Rouse
2008
PubMed

Lithium prevents and ameliorates experimental autoimmune encephalomyelitis

De Sarno, P., Axtell, R. C., Raman, C., Roth, K. A., Alessi, D. R., Jope, R. S.

Principal Investigator(s):
Dario Alessi
2008
PubMed

p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation

Cuomo, M. E., Knebel, A., Morrice, N., Paterson, H., Cohen, P., Mittnacht, S.

Principal Investigator(s):
Philip Cohen
2008
PubMed

PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response

Belgardt, B. F., Husch, A., Rother, E., Ernst, M. B., Wunderlich, F. T., Hampel, B., Klockener, T., Alessi, D., Kloppenburg, P., Bruning, J. C.

Principal Investigator(s):
Dario Alessi
2008
PubMed

Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

Bayascas, J. R., Wullschleger, S., Sakamoto, K., Garcia-Martinez, J. M., Clacher, C., Komander, D., van Aalten, D. M., Boini, K. M., Lang, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., van Diepen, J. A., Voshol, P. J., Lucocq, J. M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2008
PubMed

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains

Al-Hakim, A. K., Zagorska, A., Chapman, L., Deak, M., Peggie, M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2008
PubMed

Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast

Sanchez-Diaz, A., Marchesi, V., Murray, S., Jones, R., Pereira, G., Edmondson, R., Allen, T., Labib, K.

Principal Investigator(s):
Karim Labib
2008
PubMed

Carrier erythrocyte entrapped thymidine phosphorylase therapy for MNGIE

Moran, N. F., Bain, M. D., Muqit, M. M., Bax, B. E.

Principal Investigator(s):
Miratul Muqit
2008
PubMed

Making connections at DNA replication forks: Mrc1 takes the lead

Labib, K.

Principal Investigator(s):
Karim Labib
2008
PubMed

The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development

Kulathu, Y., Hobeika, E., Turchinovich, G., Reth, M.

Principal Investigator(s):
Yogesh Kulathu
2008
PubMed

A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells

Ganley, I. G., Espinosa, E., Pfeffer, S. R.

Principal Investigator(s):
Ian Ganley
2008
PubMed

How is SOS activated? Let us count the ways

Findlay, G. M., Pawson, T.

Principal Investigator(s):
Greg Findlay
2008
PubMed

New insights into the chromosome cycle. Conference on the Replication & Segregation of Chromosomes

de la Cueva-Mendez, G., Labib, K.

Principal Investigator(s):
Karim Labib
2008
PubMed

A native antibody-based mobility-shift technique (NAMOS-assay) to determine the stoichiometry of multi-protein complexes.

Swamy M, Minguet S, Siegers GM, Alarcón B, Schamel WW.

Principal Investigator(s):
Mahima Swamy
2007
PubMed

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

Zagorska, A., Pozo-Guisado, E., Boudeau, J., Vitari, A. C., Rafiqi, F. H., Thastrup, J., Deak, M., Campbell, D. G., Morrice, N. A., Prescott, A. R., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2007
PubMed