Research | Publications

Year

Induction of parkin expression in the presence of oxidative stress

Yang, Y. X., Muqit, M. M., Latchman, D. S.

Principal Investigator(s):
Miratul Muqit
2006
PubMed

Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase

Yan, L., Findlay, G. M., Jones, R., Procter, J., Cao, Y., Lamb, R. F.

Principal Investigator(s):
Greg Findlay
2006
PubMed

Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells

Wossning, T., Herzog, S., Kohler, F., Meixlsperger, S., Kulathu, Y., Mittler, G., Abe, A., Fuchs, U., Borkhardt, A., Jumaa, H.

Principal Investigator(s):
Yogesh Kulathu
2006
PubMed

Two dimensional Blue Native-/SDS-PAGE analysis of SLP family adaptor protein complexes

Swamy, M., Kulathu, Y., Ernst, S., Reth, M., Schamel, W. W.

Principal Investigator(s):
Yogesh Kulathu
2006
PubMed

Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways

Sapkota, G., Knockaert, M., Alarcon, C., Montalvo, E., Brivanlou, A. H., Massague, J.

Principal Investigator(s):
Gopal Sapkota
2006
PubMed

Clues to neuro-degeneration in Niemann-Pick Type C disease from global gene expression profiling

Reddy, J. V., Ganley, I. G., Pfeffer, S. R.

Principal Investigator(s):
Ian Ganley
2006
PubMed

A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling

Reddy, J. V., Burguete, A. S., Sridevi, K., Ganley, I. G., Nottingham, R. M., Pfeffer, S. R.

Principal Investigator(s):
Ian Ganley
2006
PubMed

Mitochondria in Parkinson disease: back in fashion with a little help from genetics

Muqit, M. M., Gandhi, S., Wood, N. W.

Principal Investigator(s):
Miratul Muqit
2006
PubMed

Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

Muqit, M. M., Abou-Sleiman, P. M., Saurin, A. T., Harvey, K., Gandhi, S., Deas, E., Eaton, S., Payne Smith, M. D., Venner, K., Matilla, A., Healy, D. G., Gilks, W. P., Lees, A. J., Holton, J., Revesz, T., Parker, P. J., Harvey, R. J., Wood, N. W., Latchman, D. S.

Principal Investigator(s):
Miratul Muqit
2006
PubMed

Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling

Knockaert, M., Sapkota, G., Alarcon, C., Massague, J., Brivanlou, A. H.

Principal Investigator(s):
Gopal Sapkota
2006
PubMed

Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks

Kanemaki, M., Labib, K.

Principal Investigator(s):
Karim Labib
2006
PubMed

The role of water in computational and experimental derivation of binding thermodynamics in SH2 domains

Geroult, S., Virdee, S., Waksman, G.

Principal Investigator(s):
Satpal Virdee
2006
PubMed

Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells

Ganley, I. G., Pfeffer, S. R.

Principal Investigator(s):
Ian Ganley
2006
PubMed

PINK1 protein in normal human brain and Parkinson's disease

Gandhi, S., Muqit, M. M., Stanyer, L., Healy, D. G., Abou-Sleiman, P. M., Hargreaves, I., Heales, S., Ganguly, M., Parsons, L., Lees, A. J., Latchman, D. S., Holton, J. L., Wood, N. W., Revesz, T.

Principal Investigator(s):
Miratul Muqit
2006
PubMed

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

Gambus, A., Jones, R. C., Sanchez-Diaz, A., Kanemaki, M., van Deursen, F., Edmondson, R. D., Labib, K.

Principal Investigator(s):
Karim Labib
2006
PubMed

TAK1-binding protein 1 is a pseudophosphatase

Conner, S. H., Kular, G., Peggie, M., Shepherd, S., Schuttelkopf, A. W., Cohen, P., Van Aalten, D. M.

Principal Investigator(s):
Philip Cohen
2006
PubMed

Expanding insights of mitochondrial dysfunction in Parkinson's disease

Abou-Sleiman, P. M., Muqit, M. M., Wood, N. W.

Principal Investigator(s):
Miratul Muqit
2006
PubMed

A heterozygous effect for PINK1 mutations in Parkinson's disease?

Abou-Sleiman, P. M., Muqit, M. M., McDonald, N. Q., Yang, Y. X., Gandhi, S., Healy, D. G., Harvey, K., Harvey, R. J., Deas, E., Bhatia, K., Quinn, N., Lees, A., Latchman, D. S., Wood, N. W.

Principal Investigator(s):
Miratul Muqit
2006
PubMed

Chaperoned ubiquitylation - Crystal structures of the CHIPU box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex

Zhang, M. H., Windheim, M., Roe, S. M., Peggie, M., Cohen, P., Prodromou, C., Pearl, L. H.

Principal Investigator(s):
Philip Cohen
2005

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

Vitari, A. C., Deak, M., Morrice, N. A., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2005
PubMed