Protein transformations that change lives

Research | Publications

3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium

Budas, G. R., Sukhodub, A., Alessi, D. R., Jovanovic, A.

Principal Investigator(s):

2006

Emerging roles of pseudokinases

Boudeau, J., Miranda-Saavedra, D., Barton, G. J., Alessi, D. R.

Principal Investigator(s):

2006

Evaluation of approaches to generation of tissue-specific knock-in mice

Bayascas, J. R., Sakamoto, K., Armit, L., Arthur, J. S., Alessi, D. R.

Principal Investigator(s):

2006

Impaired intestinal and renal glucose transport in PDK-1 hypomorphic mice

Artunc, F., Rexhepaj, R., Volkl, H., Grahammer, F., Remy, C., Sandulache, D., Nasir, O., Wagner, C. A., Alessi, D. R., Lang, F.

Principal Investigator(s):

2006

LKB1-dependent signaling pathways

Alessi, D. R., Sakamoto, K., Bayascas, J. R.

Principal Investigator(s):

2006

Induction of parkin expression in the presence of oxidative stress

Yang, Y. X., Muqit, M. M., Latchman, D. S.

Principal Investigator(s):

2006

Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase

Yan, L., Findlay, G. M., Jones, R., Procter, J., Cao, Y., Lamb, R. F.

Principal Investigator(s):

2006

Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells

Wossning, T., Herzog, S., Kohler, F., Meixlsperger, S., Kulathu, Y., Mittler, G., Abe, A., Fuchs, U., Borkhardt, A., Jumaa, H.

Principal Investigator(s):

2006

Two dimensional Blue Native-/SDS-PAGE analysis of SLP family adaptor protein complexes

Swamy, M., Kulathu, Y., Ernst, S., Reth, M., Schamel, W. W.

Principal Investigator(s):

2006

Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways

Sapkota, G., Knockaert, M., Alarcon, C., Montalvo, E., Brivanlou, A. H., Massague, J.

Principal Investigator(s):

2006

Clues to neuro-degeneration in Niemann-Pick Type C disease from global gene expression profiling

Reddy, J. V., Ganley, I. G., Pfeffer, S. R.

Principal Investigator(s):

2006

A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling

Reddy, J. V., Burguete, A. S., Sridevi, K., Ganley, I. G., Nottingham, R. M., Pfeffer, S. R.

Principal Investigator(s):

2006

Mitochondria in Parkinson disease: back in fashion with a little help from genetics

Muqit, M. M., Gandhi, S., Wood, N. W.

Principal Investigator(s):

2006

Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

Muqit, M. M., Abou-Sleiman, P. M., Saurin, A. T., Harvey, K., Gandhi, S., Deas, E., Eaton, S., Payne Smith, M. D., Venner, K., Matilla, A., Healy, D. G., Gilks, W. P., Lees, A. J., Holton, J., Revesz, T., Parker, P. J., Harvey, R. J., Wood, N. W., Latchman, D. S.

Principal Investigator(s):

2006

Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling

Knockaert, M., Sapkota, G., Alarcon, C., Massague, J., Brivanlou, A. H.

Principal Investigator(s):

2006

Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks

Kanemaki, M., Labib, K.

Principal Investigator(s):

2006

The role of water in computational and experimental derivation of binding thermodynamics in SH2 domains

Geroult, S., Virdee, S., Waksman, G.

Principal Investigator(s):

2006

Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells

Ganley, I. G., Pfeffer, S. R.

Principal Investigator(s):

2006

PINK1 protein in normal human brain and Parkinson's disease

Gandhi, S., Muqit, M. M., Stanyer, L., Healy, D. G., Abou-Sleiman, P. M., Hargreaves, I., Heales, S., Ganguly, M., Parsons, L., Lees, A. J., Latchman, D. S., Holton, J. L., Wood, N. W., Revesz, T.

Principal Investigator(s):

2006

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

Gambus, A., Jones, R. C., Sanchez-Diaz, A., Kanemaki, M., van Deursen, F., Edmondson, R. D., Labib, K.

Principal Investigator(s):

2006