Research | Publications

Year

Phosphorylation of a distinct structural form of phosphatidylinositol transfer protein alpha at Ser166 by protein kinase C disrupts receptor-mediated phospholipase C signaling by inhibiting delivery of phosphatidylinositol to membranes

Morgan, C. P., Skippen, A., Segui, B., Ball, A., Allen-Baume, V., Larijani, B., Murray-Rust, J., McDonald, N., Sapkota, G., Morrice, N., Cockcroft, S.

Principal Investigator(s):
Gopal Sapkota
2004
PubMed

PDK1, the master regulator of AGC kinase signal transduction

Mora, A., Komander, D., van Aalten, D. M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2004
PubMed

Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor

Milburn, C. C., Boudeau, J., Deak, M., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):
Dario Alessi
2004
PubMed

A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs

McNeill, H., Knebel, A., Arthur, J. S., Cuenda, A., Cohen, P.

Principal Investigator(s):
Philip Cohen
2004
PubMed

The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

McManus, E. J., Collins, B. J., Ashby, P. R., Prescott, A. R., Murray-Tait, V., Armit, L. J., Arthur, J. S., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2004
PubMed

Cancer, oncogenes and signal transduction

McManus, E. J., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2004
PubMed

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

Lizcano, J. M., Goransson, O., Toth, R., Deak, M., Morrice, N. A., Boudeau, J., Hawley, S. A., Udd, L., Makela, T. P., Hardie, D. G., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2004
PubMed

ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression

Le Gallic, L., Virgilio, L., Cohen, P., Biteau, B., Mavrothalassitis, G.

Principal Investigator(s):
Philip Cohen
2004

Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1

Komander, D., Kular, G. S., Schuttelkopf, A. W., Deak, M., Prakash, K. R., Bain, J., Elliott, M., Garrido-Franco, M., Kozikowski, A. P., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):
Dario Alessi
2004
PubMed

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates

Komander, D., Fairservice, A., Deak, M., Kular, G. S., Prescott, A. R., Peter Downes, C., Safrany, S. T., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):
Dario Alessi
2004
PubMed

Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation

Jowsey, P. A., Doherty, A. J., Rouse, J.

Principal Investigator(s):
John Rouse
2004
PubMed

The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

Hinton, H. J., Alessi, D. R., Cantrell, D. A.

Principal Investigator(s):
Dario Alessi
2004
PubMed

FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P

Godi, A., Di Campli, A., Konstantakopoulos, A., Di Tullio, G., Alessi, D. R., Kular, G. S., Daniele, T., Marra, P., Lucocq, J. M., De Matteis, M. A.

Principal Investigator(s):
Dario Alessi
2004
PubMed

Regulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase Isoforms SGK1 and SGK3 expressed in Xenopus oocytes

Embark, H. M., Setiawan, W., Poppendieck, S., van de Graaf, S. F. J., Boehmer, C., Palmada, M., Wieder, T., Gerstberger, R., Cohen, P., Yun, C. C., Bindels, R. J. M., Lang, F.

Principal Investigator(s):
Philip Cohen
2004

Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event

Cole, A., Frame, S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2004
PubMed

GSK3 inhibitors: development and therapeutic potential

Cohen, P., Goedert, M.

Principal Investigator(s):
Philip Cohen
2004
PubMed

Biochemistry's fab five

Cohen, P.

Principal Investigator(s):
Philip Cohen
2004

Question and answer interview

Cohen, P.

Principal Investigator(s):
Philip Cohen
2004
PubMed

TAB3, a new binding partner of the protein kinase TAK1

Cheung, P. C., Nebreda, A. R., Cohen, P.

Principal Investigator(s):
Philip Cohen
2004
PubMed

Analysis of the LKB1-STRAD-MO25 complex

Boudeau, J., Scott, J. W., Resta, N., Deak, M., Kieloch, A., Komander, D., Hardie, D. G., Prescott, A. R., van Aalten, D. M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2004
PubMed