Protein transformations that change lives

Research | Publications

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Makela, T. P., Alessi, D. R., Hardie, D. G.

Principal Investigator(s):

2003

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

Greene, M. W., Sakaue, H., Wang, L., Alessi, D. R., Roth, R. A.

Principal Investigator(s):

2003

The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC

Friedrich, B., Feng, Y., Cohen, P., Risler, T., Vandewalle, A., Broer, S., Wang, J., Pearce, D., Lang, F.

Principal Investigator(s):

2003

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

Collins, B. J., Deak, M., Arthur, J. S., Armit, L. J., Alessi, D. R.

Principal Investigator(s):

2003

The past and future of protein phosphatase research

Cohen, P.

Principal Investigator(s):

2003

Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha

Cheung, P. C., Campbell, D. G., Nebreda, A. R., Cohen, P.

Principal Investigator(s):

2003

15-deoxy-Delta(12,14)-prostaglandin J(2) regulates endogenous cot MAPK kinase kinase 1 activity induced by lipopolysaccharide

Caivano, M., Rodriguez, C., Cohen, P., Alemany, S.

Principal Investigator(s):

2003

LKB1, a protein kinase regulating cell proliferation and polarity

Boudeau, J., Sapkota, G., Alessi, D. R.

Principal Investigator(s):

Dario Alessi, Gopal Sapkota

2003

Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients

Boudeau, J., Kieloch, A., Alessi, D. R., Stella, A., Guanti, G., Resta, N.

Principal Investigator(s):

2003

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

Boudeau, J., Deak, M., Lawlor, M. A., Morrice, N. A., Alessi, D. R.

Principal Investigator(s):

2003

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Boudeau, J., Baas, A. F., Deak, M., Morrice, N. A., Kieloch, A., Schutkowski, M., Prescott, A. R., Clevers, H. C., Alessi, D. R.

Principal Investigator(s):

2003

Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A

Boehmer, C., Wilhelm, V., Palmada, M., Wallisch, S., Henke, G., Brinkmeier, H., Cohen, P., Pieske, B., Lang, F.

Principal Investigator(s):

2003

The specificities of protein kinase inhibitors: an update

Bain, J., McLauchlan, H., Elliott, M., Cohen, P.

Principal Investigator(s):

2003

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

Baas, A. F., Boudeau, J., Sapkota, G. P., Smit, L., Medema, R., Morrice, N. A., Alessi, D. R., Clevers, H. C.

Principal Investigator(s):

Dario Alessi, Gopal Sapkota

2003

Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8

Walden, H., Podgorski, M. S., Schulman, B. A.

2003

The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1

Walden, H., Podgorski, M. S., Huang, D. T., Miller, D. W., Howard, R. J., Minor, D. L., Jr., Holton, J. M., Schulman, B. A.

2003

Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo

Kanemaki, M., Sanchez-Diaz, A., Gambus, A., Labib, K.

Principal Investigator(s):

2003

Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs

Zhang, H., Zha, X., Tan, Y., Hornbeck, P. V., Mastrangelo, A. J., Alessi, D. R., Polakiewicz, R. D., Comb, M. J.

Principal Investigator(s):

2002

The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1

Yun, C. C., Palmada, M., Embark, H. M., Fedorenko, O., Feng, Y. X., Henke, G., Setiawan, I., Boehmer, C., Weinman, E. J., Sandrasagra, S., Korbmacher, C., Cohen, P., Pearce, D., Lang, F.

Principal Investigator(s):

2002

MSK1 and MSK2 are required for the mitogen-and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

Wiggin, G. R., Soloaga, A., Foster, J. M., Murray-Tait, V., Cohen, P., Arthur, J. S. C.

Principal Investigator(s):

2002