Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs

Zhang, H., Zha, X., Tan, Y., Hornbeck, P. V., Mastrangelo, A. J., Alessi, D. R., Polakiewicz, R. D., Comb, M. J.

Principal Investigator(s):

2002

The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1

Yun, C. C., Palmada, M., Embark, H. M., Fedorenko, O., Feng, Y. X., Henke, G., Setiawan, I., Boehmer, C., Weinman, E. J., Sandrasagra, S., Korbmacher, C., Cohen, P., Pearce, D., Lang, F.

Principal Investigator(s):

2002

MSK1 and MSK2 are required for the mitogen-and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

Wiggin, G. R., Soloaga, A., Foster, J. M., Murray-Tait, V., Cohen, P., Arthur, J. S. C.

Principal Investigator(s):

2002

MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

Wiggin, G. R., Soloaga, A., Foster, J. M., Murray-Tait, V., Cohen, P., Arthur, J. S.

Principal Investigator(s):

2002

Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin

Velasco, G., Armstrong, C., Morrice, N., Frame, S., Cohen, P.

Principal Investigator(s):

2002

Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons

Trotter, L., Panton, W., Hajimohamadreza, I., Petalidis, L., Ward, R., Fleming, Y., Armstrong, C. G., Cohen, P., Karran, E. H., Kinloch, R. A.

Principal Investigator(s):

2002

Phosphorylation of tyrosine hydroxylase in isolated mice adrenal glands

Toska, K., Kleppe, R., Cohen, P., Haavik, J.

Principal Investigator(s):

2002

Regulation of tyrosine hydroxylase by stress-activated protein kinases

Toska, K., Kleppe, R., Armstrong, C. G., Morrice, N. A., Cohen, P., Haavik, J.

Principal Investigator(s):

2002

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

Thomas, C. C., Deak, M., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):

2002

Dario Alessi, Gopal Sapkota

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

Sapkota, G. P., Deak, M., Kieloch, A., Morrice, N., Goodarzi, A. A., Smythe, C., Shiloh, Y., Lees-Miller, S. P., Alessi, D. R.

Principal Investigator(s):

2002

Dario Alessi, Gopal Sapkota

Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome

Sapkota, G. P., Boudeau, J., Deak, M., Kieloch, A., Morrice, N., Alessi, D. R.

Principal Investigator(s):

2002

Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs

Rousseau, S., Morrice, N., Peggie, M., Campbell, D. G., Gaestel, M., Cohen, P.

Principal Investigator(s):

2002

A non-radioactive method for the assay of many serine/threonine-specific protein kinases

Ross, H., Armstrong, C. G., Cohen, P.

Principal Investigator(s):

2002

Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

Rena, G., Woods, Y. L., Prescott, A. R., Peggie, M., Unterman, T. G., Williams, M. R., Cohen, P.

Principal Investigator(s):

2002

TSC1-TSC2: a complex tale of PKB-mediated S6K regulation

McManus, E. J., Alessi, D. R.

Principal Investigator(s):

2002

Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo

Lizcano, J. M., Deak, M., Morrice, N., Kieloch, A., Hastie, C. J., Dong, L., Schutkowski, M., Reimer, U., Alessi, D. R.

Principal Investigator(s):

2002

The insulin signalling pathway

Lizcano, J. M., Alessi, D. R.

Principal Investigator(s):

2002

Essential role of PDK1 in regulating cell size and development in mice

Lawlor, M. A., Mora, A., Ashby, P. R., Williams, M. R., Murray-Tait, V., Malone, L., Prescott, A. R., Lucocq, J. M., Alessi, D. R.

Principal Investigator(s):

2002

Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways

Knebel, A., Haydon, C. E., Morrice, N., Cohen, P.

Principal Investigator(s):

2002