Protein transformations that change lives

Research | Publications

MAPK-activated protein kinases

Arthur, S., Cohen, P.

Principal Investigator(s):

2001

Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture

Alessi, D. R.

Principal Investigator(s):

2001

Tiny TIM: a small, tetrameric, hyperthermostable triosephosphate isomerase

Walden, H., Bell, G. S., Russell, R. J., Siebers, B., Hensel, R., Taylor, G. L.

2001

Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis

Lee, M. J., Thangada, S., Paik, J. H., Sapkota, G. P., Ancellin, N., Chae, S. S., Wu, M., Morales-Ruiz, M., Sessa, W. C., Alessi, D. R., Hla, T.

Principal Investigator(s):

Dario Alessi, Gopal Sapkota

2001

MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint

Labib, K., Kearsey, S. E., Diffley, J. F.

Principal Investigator(s):

2001

Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

Labib, K., Diffley, J. F.

Principal Investigator(s):

2001

Interaction of phospholipase D1 with a casein-kinase-2-like serine kinase

Ganley, I. G., Walker, S. J., Manifava, M., Li, D., Brown, H. A., Ktistakis, N. T.

Principal Investigator(s):

2001

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

Williams, M. R., Arthur, J. S., Balendran, A., van der Kaay, J., Poli, V., Cohen, P., Alessi, D. R.

Principal Investigator(s):

Dario Alessi, Philip Cohen

2000

Phosphorylation of the skeletal muscle glycogen-targetting subunit of protein phosphatase 1 in response to adrenaline in vivo

Walker, K. S., Watt, P. W., Cohen, P.

Principal Investigator(s):

2000

The PI3K-PDK1 connection: more than just a road to PKB

Vanhaesebroeck, B., Alessi, D. R.

Principal Investigator(s):

2000

Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity

Schmoll, D., Walker, K. S., Alessi, D. R., Grempler, R., Burchell, A., Guo, S., Walther, R., Unterman, T. G.

Principal Investigator(s):

2000

Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1

Ryder, J. W., Fahlman, R., Wallberg-Henriksson, H., Alessi, D. R., Krook, A., Zierath, J. R.

Principal Investigator(s):

2000

Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155

Lizcano, J. M., Morrice, N., Cohen, P.

Principal Investigator(s):

2000

Effects of exercise on mitogen- and stress-activated kinase signal transduction in human skeletal muscle

Krook, A., Widegren, U., Jiang, X. J., Henriksson, J., Wallberg-Henriksson, H., Alessi, D., Zierath, J. R.

Principal Investigator(s):

2000

Serine 727 phosphorylation and activation of cytosolic phospholipase A(2) by MNK1-related protein kinases

Hefner, Y., Borsch-Haubold, A. G., Murakami, M., Wilde, J. I., Pasquet, S., Schieltz, D., Ghomashchi, F., Yates, J. R., Armstrong, C. G., Paterson, A., Cohen, P., Fukunaga, R., Hunter, T., Kudo, I., Watson, S. P., Gelb, M. H.

Principal Investigator(s):

2000

Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1 potential involvement of src kinase

Grillo, S., Gremeaux, T., Casamayor, A., Alessi, D. R., Le Marchand-Brustel, Y., Tanti, J. F.

Principal Investigator(s):

2000

Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7

Fleming, Y., Armstrong, C. G., Morrice, N., Paterson, A., Goedert, M., Cohen, P.

Principal Investigator(s):

2000

Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase

Dowler, S., Montalvo, L., Cantrell, D., Morrice, N., Alessi, D. R.

Principal Investigator(s):

2000

Identification of PH domains with novel phosphoinositide binding specificities

Dowler, S., Currie, R. A. , Campbell, D. G., Deak, M., Downes, C. P., Alessi, D. R.

Principal Investigator(s):

2000

Partial purification and characterization of a wortmannin-sensitive and insulin-stimulated protein kinase that activates heart 6-phosphofructo-2-kinase

Deprez, J., Bertrand, L., Alessi, D. R., Krause, U., Hue, L., Rider, M. H.

Principal Investigator(s):

2000