Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

2000

Use of kinase inhibitors to dissect signaling pathways

Cuenda, A., Alessi, D. R.

Principal Investigator(s):

2000

The regulation of protein function by multisite phosphorylation--a 25 year update

Cohen, P.

Principal Investigator(s):

2000

Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages

Caivano, M., Cohen, P.

Principal Investigator(s):

2000

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

Biondi, R. M., Cheung, P. C., Casamayor, A., Deak, M., Currie, R. A., Alessi, D. R.

Principal Investigator(s):

2000

Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms

Balendran, A., Hare, G. R., Kieloch, A., Williams, M. R., Alessi, D. R.

Principal Investigator(s):

2000

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1

Balendran, A., Biondi, R. M., Cheung, P. C., Casamayor, A., Deak, M., Alessi, D. R.

Principal Investigator(s):

2000

MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells

Arthur, J. S. C., Cohen, P.

Principal Investigator(s):

2000

DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p

Tercero, J. A., Labib, K., Diffley, J. F.

Principal Investigator(s):

2000

LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae

Rouse, J., Jackson, S. P.

Principal Investigator(s):

John Rouse

2000

Uninterrupted MCM2-7 function required for DNA replication fork progression

Labib, K., Tercero, J. A., Diffley, J. F.

Principal Investigator(s):

2000

Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18

Kearsey, S. E., Montgomery, S., Labib, K., Lindner, K.

Principal Investigator(s):

2000

A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls

Grallert, B., Kearsey, S. E., Lenhard, M., Carlson, C. R., Nurse, P., Boye, E., Labib, K.

Principal Investigator(s):

2000

Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase

Godber, B. L., Doel, J. J., Sapkota, G. P., Blake, D. R., Stevens, C. R., Eisenthal, R., Harrison, R.

Principal Investigator(s):

Gopal Sapkota

2000

Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast

Diffley, J. F., Bousset, K., Labib, K., Noton, E. A., Santocanale, C., Tercero, J. A.

Principal Investigator(s):

2000

MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells

Arthur, J. S., Cohen, P.

Principal Investigator(s):

2000

Nuclear organisation of NIPP1, a regulatory subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors

Trinkle-Mulcahy, L., Ajuh, P., Prescott, A., Claverie-Martin, F., Cohen, S., Lamond, A. I., Cohen, P.

Principal Investigator(s):

1999

A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin

Thomas, G. M., Frame, S., Goedert, M., Nathke, I., Polakis, P., Cohen, P.

Principal Investigator(s):

1999

Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells

Shaw, M., Cohen, P.

Principal Investigator(s):

1999

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

Rena, G., Guo, S., Cichy, S. C., Unterman, T. G., Cohen, P.

Principal Investigator(s):

1999