Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

2000

Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7

Fleming, Y., Armstrong, C. G., Morrice, N., Paterson, A., Goedert, M., Cohen, P.

Principal Investigator(s):

2000

Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase

Dowler, S., Montalvo, L., Cantrell, D., Morrice, N., Alessi, D. R.

Principal Investigator(s):

2000

Identification of PH domains with novel phosphoinositide binding specificities

Dowler, S., Currie, R. A. , Campbell, D. G., Deak, M., Downes, C. P., Alessi, D. R.

Principal Investigator(s):

2000

Partial purification and characterization of a wortmannin-sensitive and insulin-stimulated protein kinase that activates heart 6-phosphofructo-2-kinase

Deprez, J., Bertrand, L., Alessi, D. R., Krause, U., Hue, L., Rider, M. H.

Principal Investigator(s):

2000

Specificity and mechanism of action of some commonly used protein kinase inhibitors

Davies, S. P., Reddy, H., Caivano, M., Cohen, P.

Principal Investigator(s):

2000

Use of kinase inhibitors to dissect signaling pathways

Cuenda, A., Alessi, D. R.

Principal Investigator(s):

2000

The regulation of protein function by multisite phosphorylation--a 25 year update

Cohen, P.

Principal Investigator(s):

2000

Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages

Caivano, M., Cohen, P.

Principal Investigator(s):

2000

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

Biondi, R. M., Cheung, P. C., Casamayor, A., Deak, M., Currie, R. A., Alessi, D. R.

Principal Investigator(s):

2000

Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms

Balendran, A., Hare, G. R., Kieloch, A., Williams, M. R., Alessi, D. R.

Principal Investigator(s):

2000

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1

Balendran, A., Biondi, R. M., Cheung, P. C., Casamayor, A., Deak, M., Alessi, D. R.

Principal Investigator(s):

2000

MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells

Arthur, J. S. C., Cohen, P.

Principal Investigator(s):

2000

DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p

Tercero, J. A., Labib, K., Diffley, J. F.

Principal Investigator(s):

2000

LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae

Rouse, J., Jackson, S. P.

Principal Investigator(s):

John Rouse

2000

Uninterrupted MCM2-7 function required for DNA replication fork progression

Labib, K., Tercero, J. A., Diffley, J. F.

Principal Investigator(s):

2000

Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18

Kearsey, S. E., Montgomery, S., Labib, K., Lindner, K.

Principal Investigator(s):

2000

A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls

Grallert, B., Kearsey, S. E., Lenhard, M., Carlson, C. R., Nurse, P., Boye, E., Labib, K.

Principal Investigator(s):

2000

Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase

Godber, B. L., Doel, J. J., Sapkota, G. P., Blake, D. R., Stevens, C. R., Eisenthal, R., Harrison, R.

Principal Investigator(s):

Gopal Sapkota

2000

Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast

Diffley, J. F., Bousset, K., Labib, K., Noton, E. A., Santocanale, C., Tercero, J. A.

Principal Investigator(s):

2000