Research | Publications

Year

Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo

Lizcano, J. M., Deak, M., Morrice, N., Kieloch, A., Hastie, C. J., Dong, L., Schutkowski, M., Reimer, U., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2002
PubMed

The insulin signalling pathway

Lizcano, J. M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2002
PubMed

Essential role of PDK1 in regulating cell size and development in mice

Lawlor, M. A., Mora, A., Ashby, P. R., Williams, M. R., Murray-Tait, V., Malone, L., Prescott, A. R., Lucocq, J. M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2002
PubMed

Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways

Knebel, A., Haydon, C. E., Morrice, N., Cohen, P.

Principal Investigator(s):
Philip Cohen
2002
PubMed

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo

Kimber, W. A., Trinkle-Mulcahy, L., Cheung, P. C., Deak, M., Marsden, L. J., Kieloch, A., Watt, S., Javier, R. T., Gray, A., Downes, C. P., Lucocq, J. M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2002
PubMed

Identification of a phosphorylation site on skeletal muscle myosin light chain kinase that becomes phosphorylated during muscle contraction

Haydon, C. E., Watt, P. W., Morrice, N., Knebel, A., Gaestel, M., Cohen, P.

Principal Investigator(s):
Philip Cohen
2002
PubMed

Bi-functional, substrate mimicking RNA inhibits MSK1-mediated cAMP-response element-binding protein phosphorylation and reveals magnesium ion-dependent conformational changes of the kinase

Hamm, J., Alessi, D. R., Biondi, R. M.

Principal Investigator(s):
Dario Alessi
2002
PubMed

IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1

Gamper, N., Fillon, S., Huber, S. M., Feng, Y., Kobayashi, T., Cohen, P., Lang, F.

Principal Investigator(s):
Philip Cohen
2002

K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK

Gamper, N., Fillon, S., Feng, Y., Friedrich, B., Lang, P. A., Henke, G., Huber, S. M., Kobayashi, T., Cohen, P., Lang, F.

Principal Investigator(s):
Philip Cohen
2002

Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes

Fagerholm, S., Morrice, N., Gahmberg, C. G., Cohen, P.

Principal Investigator(s):
Philip Cohen
2002
PubMed

Protein lipid overlay assay

Dowler, S., Kular, G., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2002
PubMed

Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

Douglas, P., Sapkota, G. P., Morrice, N., Yu, Y., Goodarzi, A. A., Merkle, D., Meek, K., Alessi, D. R., Lees-Miller, S. P.

Principal Investigator(s):
Dario Alessi, Gopal Sapkota
2002
PubMed

The origins of protein phosphorylation

Cohen, P.

Principal Investigator(s):
Philip Cohen
2002
PubMed

Protein kinases--the major drug targets of the twenty-first century?

Cohen, P.

Principal Investigator(s):
Philip Cohen
2002
PubMed

Drug use and the risk of major depressive disorder, alcohol dependence, and substance use disorders

Brook, D. W., Brook, J. S., Zhang, C. S., Cohen, P., Whiteman, M.

Principal Investigator(s):
Philip Cohen
2002

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

Biondi, R. M., Komander, D., Thomas, C. C., Lizcano, J. M., Deak, M., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):
Dario Alessi
2002
PubMed

Premarital cohabitation and housework: Couples in cross-national perspective

Batalova, J. A., Cohen, P. N.

Principal Investigator(s):
Philip Cohen
2002

Efficacy of the anti-TNF-alpha antibody infliximab against refractory systemic vasculitides: an open pilot study on 10 patients

Bartolucci, P., Ramanoelina, J., Cohen, P., Mahr, A., Godmer, P., Le Hello, C., Guillevin, L.

Principal Investigator(s):
Philip Cohen
2002

Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo

Rouse, J., Jackson, S. P.

Principal Investigator(s):
John Rouse
2002
PubMed

Interfaces between the detection, signaling, and repair of DNA damage

Rouse, J., Jackson, S. P.

Principal Investigator(s):
John Rouse
2002
PubMed