Research | Publications

Year

Stimulation of renal Na+ dicarboxylate cotransporter 1 by Na+/H+ exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B

Boehmer, C., Embark, H. M., Bauer, A., Palmada, M., Yun, C. H., Weinman, E. J., Endou, H., Cohen, P., Lahme, S., Bichler, K. H., Lang, F.

Principal Investigator(s):
Philip Cohen
2004

Structure and function of a regulated archaeal triosephosphate isomerase adapted to high temperature

Walden, H., Taylor, G. L., Lorentzen, E., Pohl, E., Lilie, H., Schramm, A., Knura, T., Stubbe, K., Tjaden, B., Hensel, R.

2004
PubMed

Triosephosphate isomerase of the hyperthermophile Thermoproteus tenax: thermostability is not everything

Walden, H., Taylor, G., Lilie, H., Knura, T., Hensel, R.

2004
PubMed

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., Albanese, A., Nussbaum, R., Gonzalez-Maldonado, R., Deller, T., Salvi, S., Cortelli, P., Gilks, W. P., Latchman, D. S., Harvey

Principal Investigator(s):
Miratul Muqit
2004
PubMed

The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus

Theodossis, A., Walden, H., Westwick, E. J., Connaris, H., Lamble, H. J., Hough, D. W., Danson, M. J., Taylor, G. L.

2004
PubMed

Rapid depletion of budding yeast proteins by fusion to a heat-inducible degron

Sanchez-Diaz, A., Kanemaki, M., Marchesi, V., Labib, K.

Principal Investigator(s):
Karim Labib
2004
PubMed

Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival

Muqit, M. M., Davidson, S. M., Payne Smith, M. D., MacCormac, L. P., Kahns, S., Jensen, P. H., Wood, N. W., Latchman, D. S.

Principal Investigator(s):
Miratul Muqit
2004
PubMed

Reduction in endogenous parkin levels renders glial cells sensitive to both caspase-dependent and caspase-independent cell death

MacCormac, L. P., Muqit, M. M., Faulkes, D. J., Wood, N. W., Latchman, D. S.

Principal Investigator(s):
Miratul Muqit
2004
PubMed

Ubiquitin-like protein activation

Huang, D. T., Walden, H., Duda, D., Schulman, B. A.

2004
PubMed

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

Harrington, L. S., Findlay, G. M., Gray, A., Tolkacheva, T., Wigfield, S., Rebholz, H., Barnett, J., Leslie, N. R., Cheng, S., Shepherd, P. R., Gout, I., Downes, C. P., Lamb, R. F.

Principal Investigator(s):
Greg Findlay
2004
PubMed

Rab9 GTPase regulates late endosome size and requires effector interaction for its stability

Ganley, I. G., Carroll, K., Bittova, L., Pfeffer, S.

Principal Investigator(s):
Ian Ganley
2004
PubMed

Glycogen Synthase Kinase 3

Cohen, P., Frame, S.

Principal Investigator(s):
Philip Cohen
2003
PubMed

The effective use of protein kinase inhibitors

Cohen, P.

Principal Investigator(s):
Philip Cohen
2003
PubMed

Role of PDK1 in activating AGC protein kinase

Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2003
PubMed

A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun

Morton, S., Davis, R. J., McLaren, A., Cohen, P.

Principal Investigator(s):
Philip Cohen
2003
PubMed

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

Mora, A., Davies, A. M., Bertrand, L., Sharif, I., Budas, G. R., Jovanovic, S., Mouton, V., Kahn, C. R., Lucocq, J. M., Gray, G. A., Jovanovic, A., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2003
PubMed

An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro

Mody, N., Campbell, D. G., Morrice, N., Peggie, M., Cohen, P.

Principal Investigator(s):
Philip Cohen
2003
PubMed

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

Milburn, C. C., Deak, M., Kelly, S. M., Price, N. C., Alessi, D. R., Van Aalten, D. M.

Principal Investigator(s):
Dario Alessi
2003
PubMed

Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B

Lizcano, J. M., Alrubaie, S., Kieloch, A., Deak, M., Leevers, S. J., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2003
PubMed

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

Komander, D., Kular, G. S., Bain, J., Elliott, M., Alessi, D. R., Van Aalten, D. M.

Principal Investigator(s):
Dario Alessi
2003
PubMed