Research | Publications

Year

GSK3 inhibitors: development and therapeutic potential

Cohen, P., Goedert, M.

Principal Investigator(s):
Philip Cohen
2004
PubMed

Biochemistry's fab five

Cohen, P.

Principal Investigator(s):
Philip Cohen
2004

Question and answer interview

Cohen, P.

Principal Investigator(s):
Philip Cohen
2004
PubMed

TAB3, a new binding partner of the protein kinase TAK1

Cheung, P. C., Nebreda, A. R., Cohen, P.

Principal Investigator(s):
Philip Cohen
2004
PubMed

Analysis of the LKB1-STRAD-MO25 complex

Boudeau, J., Scott, J. W., Resta, N., Deak, M., Kieloch, A., Komander, D., Hardie, D. G., Prescott, A. R., van Aalten, D. M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2004
PubMed

Stimulation of renal Na+ dicarboxylate cotransporter 1 by Na+/H+ exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B

Boehmer, C., Embark, H. M., Bauer, A., Palmada, M., Yun, C. H., Weinman, E. J., Endou, H., Cohen, P., Lahme, S., Bichler, K. H., Lang, F.

Principal Investigator(s):
Philip Cohen
2004

Structure and function of a regulated archaeal triosephosphate isomerase adapted to high temperature

Walden, H., Taylor, G. L., Lorentzen, E., Pohl, E., Lilie, H., Schramm, A., Knura, T., Stubbe, K., Tjaden, B., Hensel, R.

2004
PubMed

Triosephosphate isomerase of the hyperthermophile Thermoproteus tenax: thermostability is not everything

Walden, H., Taylor, G., Lilie, H., Knura, T., Hensel, R.

2004
PubMed

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., Albanese, A., Nussbaum, R., Gonzalez-Maldonado, R., Deller, T., Salvi, S., Cortelli, P., Gilks, W. P., Latchman, D. S., Harvey

Principal Investigator(s):
Miratul Muqit
2004
PubMed

The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus

Theodossis, A., Walden, H., Westwick, E. J., Connaris, H., Lamble, H. J., Hough, D. W., Danson, M. J., Taylor, G. L.

2004
PubMed

Rapid depletion of budding yeast proteins by fusion to a heat-inducible degron

Sanchez-Diaz, A., Kanemaki, M., Marchesi, V., Labib, K.

Principal Investigator(s):
Karim Labib
2004
PubMed

Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival

Muqit, M. M., Davidson, S. M., Payne Smith, M. D., MacCormac, L. P., Kahns, S., Jensen, P. H., Wood, N. W., Latchman, D. S.

Principal Investigator(s):
Miratul Muqit
2004
PubMed

Reduction in endogenous parkin levels renders glial cells sensitive to both caspase-dependent and caspase-independent cell death

MacCormac, L. P., Muqit, M. M., Faulkes, D. J., Wood, N. W., Latchman, D. S.

Principal Investigator(s):
Miratul Muqit
2004
PubMed

Ubiquitin-like protein activation

Huang, D. T., Walden, H., Duda, D., Schulman, B. A.

2004
PubMed

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

Harrington, L. S., Findlay, G. M., Gray, A., Tolkacheva, T., Wigfield, S., Rebholz, H., Barnett, J., Leslie, N. R., Cheng, S., Shepherd, P. R., Gout, I., Downes, C. P., Lamb, R. F.

Principal Investigator(s):
Greg Findlay
2004
PubMed

Rab9 GTPase regulates late endosome size and requires effector interaction for its stability

Ganley, I. G., Carroll, K., Bittova, L., Pfeffer, S.

Principal Investigator(s):
Ian Ganley
2004
PubMed

Glycogen Synthase Kinase 3

Cohen, P., Frame, S.

Principal Investigator(s):
Philip Cohen
2003
PubMed

The effective use of protein kinase inhibitors

Cohen, P.

Principal Investigator(s):
Philip Cohen
2003
PubMed

Role of PDK1 in activating AGC protein kinase

Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2003
PubMed

A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun

Morton, S., Davis, R. J., McLaren, A., Cohen, P.

Principal Investigator(s):
Philip Cohen
2003
PubMed