Research | Publications

Year

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase

Wang, X., Li, W., Williams, M., Terada, N., Alessi, D. R., Proud, C. G.

Principal Investigator(s):
Dario Alessi
2001
PubMed

Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity

Thomas, C. C., Dowler, S., Deak, M., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):
Dario Alessi
2001
PubMed

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

Sapkota, G. P., Kieloch, A., Lizcano, J. M., Lain, S., Arthur, J. S., Williams, M. R., Morrice, N., Deak, M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi, Gopal Sapkota
2001
PubMed

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

Rena, G., Prescott, A. R., Guo, S., Cohen, P., Unterman, T. G.

Principal Investigator(s):
Philip Cohen
2001
PubMed

Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells

Mora, A., Sabio, G., Gonzalez-Polo, R. A., Cuenda, A., Alessi, D. R., Alonso, J. C., Fuentes, J. M., Soler, G., Centeno, F.

Principal Investigator(s):
Dario Alessi
2001
PubMed

Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway

Mody, N., Leitch, J., Armstrong, C., Dixon, J., Cohen, P.

Principal Investigator(s):
Philip Cohen
2001
PubMed

Antiischemic effects of SB203580 are mediated through the inhibition of p38 alpha mitogen-activated protein kinase - Evidence from ectopic expression of an inhibition-resistant kinase

Martin, J. L., Avkiran, M., Quinlan, R. A., Cohen, P., Marber, M. S.

Principal Investigator(s):
Philip Cohen
2001

Phosphoinositide-regulated kinases and phosphoinositide phosphatases

Leslie, N. R., Biondi, R. M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2001
PubMed

PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

Lawlor, M. A., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2001
PubMed

Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms

Lang, F., Cohen, P.

Principal Investigator(s):
Philip Cohen
2001
PubMed

A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta

Knebel, A., Morrice, N., Cohen, P.

Principal Investigator(s):
Philip Cohen
2001
PubMed

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

Frame, S., Cohen, P., Biondi, R. M.

Principal Investigator(s):
Philip Cohen
2001
PubMed

GSK3 takes centre stage more than 20 years after its discovery

Frame, S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2001
PubMed

An essential role for calmodulin in regulating human T cell aggregation

Fagerholm, S. C., Prescott, A., Cohen, P., Gahmberg, C. G.

Principal Investigator(s):
Philip Cohen
2001
PubMed

The renaissance of GSK3

Cohen, P., Frame, S.

Principal Investigator(s):
Philip Cohen
2001
PubMed

The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture

Cohen, P.

Principal Investigator(s):
Philip Cohen
2001
PubMed

Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi

Cheung, P. C., Trinkle-Mulcahy, L., Cohen, P., Lucocq, J. M.

Principal Investigator(s):
Philip Cohen
2001
PubMed

The induction of cyclooxygenase-2 mRNA in macrophages is biphasic and requires both CCAAT enhancer-binding protein beta (C/EBP beta ) and C/EBP delta transcription factors

Caivano, M., Gorgoni, B., Cohen, P., Poli, V.

Principal Investigator(s):
Philip Cohen
2001
PubMed

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB

Biondi, R. M., Kieloch, A., Currie, R. A., Deak, M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2001
PubMed

Mitogen-activated protein kinases

Arthur, S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2001