Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

The chromosome replication cycle

Diffley, J. F., Labib, K.

Principal Investigator(s):

Karim Labib

2002

A minimal cytoplasmic subdomain of the erythropoietin receptor mediates p70 S6 kinase phosphorylation

Zhang, M. Y., Barber, D. L., Alessi, D. R., Bell, L. L., Stine, C., Nguyen, M. H., Beattie, B. K., Cheung, J. Y., Miller, B. A.

Principal Investigator(s):

2001

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

Woods, Y. L., Rena, G., Morrice, N., Barthel, A., Becker, W., Guo, S., Unterman, T. G., Cohen, P.

Principal Investigator(s):

2001

The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

Woods, Y. L., Cohen, P., Becker, W., Jakes, R., Goedert, M., Wang, X., Proud, C. G.

Principal Investigator(s):

2001

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase

Wang, X., Li, W., Williams, M., Terada, N., Alessi, D. R., Proud, C. G.

Principal Investigator(s):

2001

Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity

Thomas, C. C., Dowler, S., Deak, M., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):

2001

Dario Alessi, Gopal Sapkota

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

Sapkota, G. P., Kieloch, A., Lizcano, J. M., Lain, S., Arthur, J. S., Williams, M. R., Morrice, N., Deak, M., Alessi, D. R.

Principal Investigator(s):

2001

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

Rena, G., Prescott, A. R., Guo, S., Cohen, P., Unterman, T. G.

Principal Investigator(s):

2001

Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells

Mora, A., Sabio, G., Gonzalez-Polo, R. A., Cuenda, A., Alessi, D. R., Alonso, J. C., Fuentes, J. M., Soler, G., Centeno, F.

Principal Investigator(s):

2001

Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway

Mody, N., Leitch, J., Armstrong, C., Dixon, J., Cohen, P.

Principal Investigator(s):

2001

Antiischemic effects of SB203580 are mediated through the inhibition of p38 alpha mitogen-activated protein kinase - Evidence from ectopic expression of an inhibition-resistant kinase

Martin, J. L., Avkiran, M., Quinlan, R. A., Cohen, P., Marber, M. S.

Principal Investigator(s):

2001

Phosphoinositide-regulated kinases and phosphoinositide phosphatases

Leslie, N. R., Biondi, R. M., Alessi, D. R.

Principal Investigator(s):

2001

PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

Lawlor, M. A., Alessi, D. R.

Principal Investigator(s):

2001

Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms

Lang, F., Cohen, P.

Principal Investigator(s):

2001

A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta

Knebel, A., Morrice, N., Cohen, P.

Principal Investigator(s):

2001

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

Frame, S., Cohen, P., Biondi, R. M.

Principal Investigator(s):

2001

GSK3 takes centre stage more than 20 years after its discovery

Frame, S., Cohen, P.

Principal Investigator(s):

2001

An essential role for calmodulin in regulating human T cell aggregation

Fagerholm, S. C., Prescott, A., Cohen, P., Gahmberg, C. G.

Principal Investigator(s):

2001

The renaissance of GSK3

Cohen, P., Frame, S.

Principal Investigator(s):

2001