Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

1999

Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast

Casamayor, A., Torrance, P. D., Kobayashi, T., Thorner, J., Alessi, D. R.

Principal Investigator(s):

1999

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

Casamayor, A., Morrice, N. A., Alessi, D. R.

Principal Investigator(s):

1999

Phosphorylation of cytosolic phospholipase A(2) in platelets is mediated by multiple stress-activated protein kinase pathways

Borsch-Haubold, A. G., Ghomashchi, F., Pasquet, S., Goedert, M., Cohen, P., Gelb, M. H., Watson, S. P.

Principal Investigator(s):

1999

Heart 6-phosphofructo-2-kinase activation by insulin results from Ser-466 and Ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase B

Bertrand, L., Alessi, D. R., Deprez, J., Deak, M., Viaene, E., Rider, M. H., Hue, L.

Principal Investigator(s):

1999

Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252

Balendran, A., Currie, R., Armstrong, C. G., Avruch, J., Alessi, D. R.

Principal Investigator(s):

1999

PDK1 and PDK2 may be the same enzyme; PDK1 displays PDK2 activity in the presence of a synthetic peptide

Balendran, A., Casamayor, A., Deak, M., Paterson, A., Gaffney, P., Currie, R., Downes, C. P., Alessi, D. R.

Principal Investigator(s):

1999

G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus

Labib, K., Diffley, J. F., Kearsey, S. E.

Principal Investigator(s):

Karim Labib

1999

Dario Alessi, Philip Cohen

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

Walker, K. S., Deak, M., Paterson, A., Hudson, K., Cohen, P., Alessi, D. R.

Principal Investigator(s):

1998

Dario Alessi, Philip Cohen

The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

Shaw, M., Cohen, P., Alessi, D. R.

Principal Investigator(s):

1998

Dario Alessi, Philip Cohen

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

Le Good, J. A., Ziegler, W. H., Parekh, D. B., Alessi, D. R., Cohen, P., Parker, P. J.

Principal Investigator(s):

1998

Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro

Lawler, S., Fleming, Y., Goedert, M., Cohen, P.

Principal Investigator(s):

1998

Protein kinase B mediates the insulin induced increase in glucose and amino acid uptake in L6 myotubes

Hajduch, E. , Alessi, D. R., Hemmings, B. A., Hundal, H.

Principal Investigator(s):

1998

Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

Eyers, P. A., Craxton, M., Morrice, N., Cohen, P., Goedert, M.

Principal Investigator(s):

1998

Arsenite blocks growth factor induced activation of the MAP kinase cascade, upstream of Ras and downstream of Grb2-Sos

Doza, Y. N., Hall-Jackson, C. A., Cohen, P.

Principal Investigator(s):

1998

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

Deak, M., Clifton, A. D., Lucocq, L. M., Alessi, D. R.

Principal Investigator(s):

1998

Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK

Dalby, K. N., Morrice, N., Caudwell, F. B., Avruch, J., Cohen, P.

Principal Investigator(s):

1998

Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid

Cohen, P., Goedert, M.

Principal Investigator(s):

1998

The P in protein

Cohen, P.

Principal Investigator(s):

1998

The Department of Biochemistry at the University of Dundee

Cohen, P.

Principal Investigator(s):

1998