Research | Publications

Year

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., Cohen, P.

Principal Investigator(s):
Dario Alessi, Philip Cohen
1997
PubMed

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

Alessi, D. R., Deak, M., Casamayor, A., Caudwell, F. B., Morrice, N., Norman, D. G., Gaffney, P., Reese, C. B., MacDougall, C. N., Harbison, D., Ashworth, A., Bownes, M.

Principal Investigator(s):
Dario Alessi
1997
PubMed

The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase

Alessi, D. R.

Principal Investigator(s):
Dario Alessi
1997
PubMed

A stress-activated kinase cascade can mediate the activation of tyrosine hydroxylase in chromaffin cells

Thomas, G. M., Haavik, J., Cohen, P.

Principal Investigator(s):
Philip Cohen
1997
PubMed

Don't leave dignity out of the cloning debate

Labib, K.

Principal Investigator(s):
Karim Labib
1997
PubMed

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2

Tan, Y., Rouse, J., Zhang, A. H., Cariati, S., Cohen, P., Comb, M. J.

Principal Investigator(s):
Philip Cohen, John Rouse
1996

Cellular stresses and cytokines activate multiple mitogen-activated-protein kinase kinase homologues in PC12 and KB cells

Meier, R., Rouse, J., Cuenda, A., Nebreda, A. R., Cohen, P.

Principal Investigator(s):
Philip Cohen, John Rouse
1996
PubMed

The protein kinase Akt binds to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

James, S. R., Downes, C. P., Gigg, R. , Grove, S. J. A. , Holmes, A. B., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
1996

p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient

Hazzalin, C. A., Cano, E., Cuenda, A., Barratt, M. J., Cohen, P., Mahadevan, L. C.

Principal Investigator(s):
Philip Cohen
1996

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase

Groom, L. A., Sneddon, A. A., Alessi, D. R., Dowd, S., Keyse, S. M.

Principal Investigator(s):
Dario Alessi
1996
PubMed

Cloning and expression of cytosolic phospholipase A(2) (cPLA(2)) and a naturally occurring variant - Phosphorylation of Ser505 of recombinant cPLA(2) by p42 mitogen-activated protein kinase results in an increase in specific activity

Gordon, R. D., Leighton, I. A., Campbell, D. G., Cohen, P., Creaney, A., Wilton, D. C., Masters, D. J., Ritchie, G. A. F., Mott, R., Taylor, I. W. F., Bundell, K. R., Douglas, L., Morten, J., Needham, M.

Principal Investigator(s):
Philip Cohen
1996

Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells

Cuenda, A., Alonso, G., Morrice, N., Jones, M., Meier, R., Cohen, P., Nebreda, A. R.

Principal Investigator(s):
Philip Cohen
1996
PubMed

Dissection of protein kinase cascades that mediate cellular response to cytokines and cellular stress

Cohen, P.

Principal Investigator(s):
Philip Cohen
1996
PubMed

A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress

Clifton, A. D., Young, P. R., Cohen, P.

Principal Investigator(s):
Philip Cohen
1996

Identification of anisomycin-activated kinases p45 and p55 in murine cells as MAPKAP kinase-2

Cano, E., Doza, Y. N., BenLevy, R., Cohen, P., Mahadevan, L. C.

Principal Investigator(s):
Philip Cohen
1996

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumour necrosis factor

Beyaert, R., Cuenda, A., VandenBerghe, W., Plaisance, S., Lee, J. C., Haegeman, G., Cohen, P., Fiers, W.

Principal Investigator(s):
Philip Cohen
1996

Molecular basis for the substrate specificity of protein kinase B; Comparison with MAPKAP kinase-1 and p70 S6 kinase

Alessi, D. R., Caudwell, F. B., Andjelkovic, M., Hemmings, B. A., Cohen, P.

Principal Investigator(s):
Dario Alessi, Philip Cohen
1996

Mechanism of activation of protein kinase B by insulin and IGF-1

Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., Hemmings, B. A.

Principal Investigator(s):
Dario Alessi, Philip Cohen
1996

B-type cyclins regulate G1 progression in fission yeast in opposition to the p25rum1 cdk inhibitor

Martin-Castellanos, C., Labib, K., Moreno, S.

Principal Investigator(s):
Karim Labib
1996
PubMed

rum1: a CDK inhibitor regulating G1 progression in fission yeast

Labib, K., Moreno, S.

Principal Investigator(s):
Karim Labib
1996
PubMed