Research | Publications

Year

The discovery of protein phosphatases: from chaos and confusion to an understanding of their role in cell regulation and human disease

Cohen, P.

Principal Investigator(s):
Philip Cohen
1994
PubMed

Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M

Chen, Y. H., Chen, M. X., Alessi, D. R., Campbell, D. G., Shanahan, C., Cohen, P., Cohen, P. T. W.

Principal Investigator(s):
Philip Cohen, Dario Alessi
1994
PubMed

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1

Alessi, D. R., Saito, Y., Campbell, D. G., Cohen, P., Sithanandam, G., Rapp, U., Ashworth, A., Marshall, C. J., Cowley, S.

Principal Investigator(s):
Dario Alessi, Philip Cohen
1994
PubMed

Regulation of the cell cycle timing of Start in fission yeast by the rum1+ gene

Moreno, S., Labib, K., Correa, J., Nurse, P.

Principal Investigator(s):
Karim Labib
1994
PubMed

Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells

Traverse, S., Cohen, P., Paterson, H., Marshall, C., Rapp, U., Grand, R. J.

Principal Investigator(s):
Philip Cohen
1993
PubMed

Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling

Sutherland, C., Leighton, I. A., Cohen, P.

Principal Investigator(s):
Philip Cohen
1993
PubMed

Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rskmo-2. Identification of two threonines phosphorylated during activation by mitogen-activated protein kinase

Sutherland, C., Campbell, D. G., Cohen, P.

Principal Investigator(s):
Philip Cohen
1993
PubMed

Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2

Sutherland, C., Alterio, J., Campbell, D. G., Le Bourdelles, B., Mallet, J., Haavik, J., Cohen, P.

Principal Investigator(s):
Philip Cohen
1993
PubMed

The Protein-Kinase Mos Activates Map Kinase Kinase in-Vitro and Stimulates the Map Kinase Pathway in Mammalian Somatic-Cells in-Vivo

Nebreda, A. R., Hill, C., Gomez, N., Cohen, P., Hunt, T.

Principal Investigator(s):
Philip Cohen
1993

Mitogen-Activated Protein-Kinase (Map Kinase), Map Kinase Kinase and C-Mos Stimulate Glucose-Transport in Xenopus-Oocytes

Merrall, N. W., Plevin, R. J., Stokoe, D., Cohen, P., Nebreda, A. R., Gould, G. W.

Principal Investigator(s):
Philip Cohen
1993

The phosphorylation of stathmin by MAP kinase

Leighton, I. A., Curmi, P., Campbell, D. G., Cohen, P., Sobel, A.

Principal Investigator(s):
Philip Cohen
1993
PubMed

Protein Phosphatases-1, Phosphatases-2a, and Phosphatases-2c Are Protein Histidine Phosphatases

Kim, Y. H., Huang, J. M., Cohen, P., Matthews, H. R.

Principal Investigator(s):
Philip Cohen
1993

On Target with a New Mechanism for the Regulation of Protein-Phosphorylation

Hubbard, M. J., Cohen, P.

Principal Investigator(s):
Philip Cohen
1993

Protein phosphatase 2A1 is the major enzyme in vertebrate cell extracts that dephosphorylates several physiological substrates for cyclin-dependent protein kinases

Ferrigno, P., Langan, T. A., Cohen, P.

Principal Investigator(s):
Philip Cohen
1993
PubMed

An analysis of the substrate specificity of insulin-stimulated protein kinase-1, a mammalian homologue of S6 kinase-II

Donella-Deana, A., Lavoinne, A., Marin, O., Pinna, L. A., Cohen, P.

Principal Investigator(s):
Philip Cohen
1993
PubMed

Dissection of the protein phosphorylation cascades involved in insulin and growth factor action

Cohen, P.

Principal Investigator(s):
Philip Cohen
1993
PubMed

Okadaic acid-sensitive protein phosphatases dephosphorylate MARCKS, a major protein kinase C substrate

Clarke, P. R., Siddhanti, S. R., Cohen, P., Blackshear, P. J.

Principal Investigator(s):
Philip Cohen
1993
PubMed

Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme

Alessi, D. R., Street, A. J., Cohen, P., Cohen, P. T. W.

Principal Investigator(s):
Philip Cohen, Dario Alessi
1993
PubMed

The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts

Alessi, D. R., Smythe, C., Keyse, S. M.

Principal Investigator(s):
Dario Alessi
1993
PubMed

Cell cycle: bring on the phosphatases

Labib, K., Nurse, P.

Principal Investigator(s):
Karim Labib
1993
PubMed