Research | Publications

Year

Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling

Sutherland, C., Leighton, I. A., Cohen, P.

Principal Investigator(s):
Philip Cohen
1993
PubMed

Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rskmo-2. Identification of two threonines phosphorylated during activation by mitogen-activated protein kinase

Sutherland, C., Campbell, D. G., Cohen, P.

Principal Investigator(s):
Philip Cohen
1993
PubMed

Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2

Sutherland, C., Alterio, J., Campbell, D. G., Le Bourdelles, B., Mallet, J., Haavik, J., Cohen, P.

Principal Investigator(s):
Philip Cohen
1993
PubMed

The Protein-Kinase Mos Activates Map Kinase Kinase in-Vitro and Stimulates the Map Kinase Pathway in Mammalian Somatic-Cells in-Vivo

Nebreda, A. R., Hill, C., Gomez, N., Cohen, P., Hunt, T.

Principal Investigator(s):
Philip Cohen
1993

Mitogen-Activated Protein-Kinase (Map Kinase), Map Kinase Kinase and C-Mos Stimulate Glucose-Transport in Xenopus-Oocytes

Merrall, N. W., Plevin, R. J., Stokoe, D., Cohen, P., Nebreda, A. R., Gould, G. W.

Principal Investigator(s):
Philip Cohen
1993

The phosphorylation of stathmin by MAP kinase

Leighton, I. A., Curmi, P., Campbell, D. G., Cohen, P., Sobel, A.

Principal Investigator(s):
Philip Cohen
1993
PubMed

Protein Phosphatases-1, Phosphatases-2a, and Phosphatases-2c Are Protein Histidine Phosphatases

Kim, Y. H., Huang, J. M., Cohen, P., Matthews, H. R.

Principal Investigator(s):
Philip Cohen
1993

On Target with a New Mechanism for the Regulation of Protein-Phosphorylation

Hubbard, M. J., Cohen, P.

Principal Investigator(s):
Philip Cohen
1993

Protein phosphatase 2A1 is the major enzyme in vertebrate cell extracts that dephosphorylates several physiological substrates for cyclin-dependent protein kinases

Ferrigno, P., Langan, T. A., Cohen, P.

Principal Investigator(s):
Philip Cohen
1993
PubMed

An analysis of the substrate specificity of insulin-stimulated protein kinase-1, a mammalian homologue of S6 kinase-II

Donella-Deana, A., Lavoinne, A., Marin, O., Pinna, L. A., Cohen, P.

Principal Investigator(s):
Philip Cohen
1993
PubMed

Dissection of the protein phosphorylation cascades involved in insulin and growth factor action

Cohen, P.

Principal Investigator(s):
Philip Cohen
1993
PubMed

Okadaic acid-sensitive protein phosphatases dephosphorylate MARCKS, a major protein kinase C substrate

Clarke, P. R., Siddhanti, S. R., Cohen, P., Blackshear, P. J.

Principal Investigator(s):
Philip Cohen
1993
PubMed

Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme

Alessi, D. R., Street, A. J., Cohen, P., Cohen, P. T. W.

Principal Investigator(s):
Philip Cohen, Dario Alessi
1993
PubMed

The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts

Alessi, D. R., Smythe, C., Keyse, S. M.

Principal Investigator(s):
Dario Alessi
1993
PubMed

Cell cycle: bring on the phosphatases

Labib, K., Nurse, P.

Principal Investigator(s):
Karim Labib
1993
PubMed

Cell-free fusion of endocytic vesicles Is regulated by phosphorylation

Woodman, P. G., Mundy, D. I., Cohen, P., Warren, G.

Principal Investigator(s):
Philip Cohen
1992

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

Traverse, S., Gomez, N., Paterson, H., Marshall, C., Cohen, P.

Principal Investigator(s):
Philip Cohen
1992
PubMed

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

Stokoe, D., Engel, K., Campbell, D. G., Cohen, P., Gaestel, M.

Principal Investigator(s):
Philip Cohen
1992
PubMed

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase

Stokoe, D., Campbell, D. G., Nakielny, S., Hidaka, H., Leevers, S. J., Marshall, C., Cohen, P.

Principal Investigator(s):
Philip Cohen
1992
PubMed

MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase

Nakielny, S., Cohen, P., Wu, J., Sturgill, T.

Principal Investigator(s):
Philip Cohen
1992
PubMed