Research | Publications

Year

On Target with a New Mechanism for the Regulation of Protein-Phosphorylation

Hubbard, M. J., Cohen, P.

Principal Investigator(s):
Philip Cohen
1993

Protein phosphatase 2A1 is the major enzyme in vertebrate cell extracts that dephosphorylates several physiological substrates for cyclin-dependent protein kinases

Ferrigno, P., Langan, T. A., Cohen, P.

Principal Investigator(s):
Philip Cohen
1993
PubMed

An analysis of the substrate specificity of insulin-stimulated protein kinase-1, a mammalian homologue of S6 kinase-II

Donella-Deana, A., Lavoinne, A., Marin, O., Pinna, L. A., Cohen, P.

Principal Investigator(s):
Philip Cohen
1993
PubMed

Dissection of the protein phosphorylation cascades involved in insulin and growth factor action

Cohen, P.

Principal Investigator(s):
Philip Cohen
1993
PubMed

Okadaic acid-sensitive protein phosphatases dephosphorylate MARCKS, a major protein kinase C substrate

Clarke, P. R., Siddhanti, S. R., Cohen, P., Blackshear, P. J.

Principal Investigator(s):
Philip Cohen
1993
PubMed

Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme

Alessi, D. R., Street, A. J., Cohen, P., Cohen, P. T. W.

Principal Investigator(s):
Philip Cohen, Dario Alessi
1993
PubMed

The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts

Alessi, D. R., Smythe, C., Keyse, S. M.

Principal Investigator(s):
Dario Alessi
1993
PubMed

Cell cycle: bring on the phosphatases

Labib, K., Nurse, P.

Principal Investigator(s):
Karim Labib
1993
PubMed

Cell-free fusion of endocytic vesicles Is regulated by phosphorylation

Woodman, P. G., Mundy, D. I., Cohen, P., Warren, G.

Principal Investigator(s):
Philip Cohen
1992

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

Traverse, S., Gomez, N., Paterson, H., Marshall, C., Cohen, P.

Principal Investigator(s):
Philip Cohen
1992
PubMed

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

Stokoe, D., Engel, K., Campbell, D. G., Cohen, P., Gaestel, M.

Principal Investigator(s):
Philip Cohen
1992
PubMed

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase

Stokoe, D., Campbell, D. G., Nakielny, S., Hidaka, H., Leevers, S. J., Marshall, C., Cohen, P.

Principal Investigator(s):
Philip Cohen
1992
PubMed

MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase

Nakielny, S., Cohen, P., Wu, J., Sturgill, T.

Principal Investigator(s):
Philip Cohen
1992
PubMed

MAP kinase kinase from rabbit skeletal muscle. A novel dual specificity enzyme showing homology to yeast protein kinases involved in pheromone-dependent signal transduction

Nakielny, S., Campbell, D. G., Cohen, P.

Principal Investigator(s):
Philip Cohen
1992
PubMed

Ser Thr-Specific Protein Phosphatases Are Required for Both Catalytic Steps of Premessenger-Rna Splicing

Mermoud, J. E., Cohen, P., Lamond, A. I.

Principal Investigator(s):
Philip Cohen
1992

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

Liu, J., Albers, M. W., Wandless, T. J., Luan, S., Alberg, D. G., Belshaw, P. J., Cohen, P., MacKintosh, C., Klee, C. B., Schreiber, S. L.

Principal Investigator(s):
Philip Cohen
1992
PubMed

Activation of the Map Kinase Pathway by the Protein-Kinase Raf

Howe, L. R., Leevers, S. J., Gomez, N., Nakielny, S., Cohen, P., Marshall, C. J.

Principal Investigator(s):
Philip Cohen
1992

Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle to calcium

Gong, M. C., Fuglsang, A., Alessi, D., Kobayashi, S., Cohen, P., Somlyo, A. V., Somlyo, A. P.

Principal Investigator(s):
Dario Alessi, Philip Cohen
1992
PubMed

Myosin Light Chain Phosphatase-Activities and the Effects of Phosphatase Inhibitors in Tonic and Phasic Smooth-Muscle

Gong, M. C., Cohen, P., Kitazawa, T., Ikebe, M., Masuo, M., Somlyo, A. P., Somlyo, A. V.

Principal Investigator(s):
Philip Cohen
1992

Identification of a MAP kinase kinase kinase in phaeochromocytoma (PC12) cells

Gomez, N., Traverse, S., Cohen, P.

Principal Investigator(s):
Philip Cohen
1992
PubMed