Research | Publications

Year

Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide-mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages

Paul, A., Cuenda, A., Bryant, C. E., Murray, J., Chilvers, E. R., Cohen, P., Gould, G. W., Plevin, R.

Principal Investigator(s):
Philip Cohen
1999

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation

Nave, B. T., Ouwens, M., Withers, D. J., Alessi, D. R., Shepherd, P. R.

Principal Investigator(s):
Dario Alessi
1999
PubMed

Activation of the neutrophil NADPH oxidase is inhibited by SB 203580, a specific inhibitor of SAPK2/p38

Lal, A. S., Clifton, A. D., Rouse, J., Segal, A. W., Cohen, P.

Principal Investigator(s):
Philip Cohen, John Rouse
1999
PubMed

Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway

Kovarik, P., Stoiber, D., Eyers, P. A., Menghini, R., Neininger, A., Gaestel, M., Cohen, P., Decker, T.

Principal Investigator(s):
Philip Cohen
1999

Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase

Kobayashi, T., Deak, M., Morrice, N., Cohen, P.

Principal Investigator(s):
Philip Cohen
1999
PubMed

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

Kobayashi, T., Cohen, P.

Principal Investigator(s):
Philip Cohen
1999
PubMed

Stress-activated protein kinase-3 interacts with the PDZ domain of alpha 1-syntrophin - A mechanism for specific substrate recognition

Hasegawa, M., Cuenda, A., Spillantini, M. G., Thomas, G. M., Buee-Scherrer, V., Cohen, P., Goedert, M.

Principal Investigator(s):
Philip Cohen
1999

Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for ge

Hansen, L., Fjordvang, H., Rasmussen, S. K., Vestergaard, H., Echwald, S. M., Hansen, T., Alessi, D., Shenolikar, S., Saltiel, A. R., Barbetti, F., Pedersen, O.

Principal Investigator(s):
Dario Alessi
1999
PubMed

Effect of SB 203580 on the activity of c-Raf in vitro and in vivo

Hall-Jackson, C. A., Goedert, M., Hedge, P., Cohen, P.

Principal Investigator(s):
Philip Cohen
1999

Paradoxical activation of Raf by a novel Raf inhibitor

Hall-Jackson, C. A., Eyers, P. A., Cohen, P., Goedert, M., Boyle, F. T., Hewitt, N., Plant, H., Hedge, P.

Principal Investigator(s):
Philip Cohen
1999
PubMed

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

Guo, S. D., Rena, G., Cichy, S., He, X. W., Cohen, P., Unterman, T.

Principal Investigator(s):
Philip Cohen
1999

Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580

Eyers, P. A., van den, IJssel P., Quinlan, R. A., Goedert, M., Cohen, P.

Principal Investigator(s):
Philip Cohen
1999
PubMed

DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides

Dowler, S., Currie, R. A., Downes, C. P., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
1999
PubMed

Characterisation of a plant 3-phosphoinositide-dependent protein kinase-1 homologue which contains a pleckstrin homology domain

Deak, M., Casamayor, A., Currie, R. A., Downes, C. P., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
1999
PubMed

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

Currie, R. A., Walker, K. S., Gray, A., Deak, M., Casamayor, A., Downes, C. P., Cohen, P., Alessi, D. R., Lucocq, J.

Principal Investigator(s):
Dario Alessi, Philip Cohen
1999
PubMed

Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis

Cuenda, A., Cohen, P.

Principal Investigator(s):
Philip Cohen
1999
PubMed

Understanding Insulin signalling

Cohen, P.

Principal Investigator(s):
Philip Cohen
1999

The 1997 Louis Jeantet Prize Lecture. Role of protein phosphorylation in human health and disease

Cohen, P.

Principal Investigator(s):
Philip Cohen
1999

The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction

Cohen, P.

Principal Investigator(s):
Philip Cohen
1999
PubMed

The development and therapeutic potential of protein kinase inhibitors

Cohen, P.

Principal Investigator(s):
Philip Cohen
1999
PubMed