Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

2006

Expanding insights of mitochondrial dysfunction in Parkinson's disease

Abou-Sleiman, P. M., Muqit, M. M., Wood, N. W.

Principal Investigator(s):

Miratul Muqit

2006

A heterozygous effect for PINK1 mutations in Parkinson's disease?

Abou-Sleiman, P. M., Muqit, M. M., McDonald, N. Q., Yang, Y. X., Gandhi, S., Healy, D. G., Harvey, K., Harvey, R. J., Deas, E., Bhatia, K., Quinn, N., Lees, A., Latchman, D. S., Wood, N. W.

Principal Investigator(s):

Miratul Muqit

2006

Chaperoned ubiquitylation - Crystal structures of the CHIPU box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex

Zhang, M. H., Windheim, M., Roe, S. M., Peggie, M., Cohen, P., Prodromou, C., Pearl, L. H.

Principal Investigator(s):

2005

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

Vitari, A. C., Deak, M., Morrice, N. A., Alessi, D. R.

Principal Investigator(s):

2005

Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket

Villa, F., Deak, M., Bloomberg, G. B., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):

2005

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

Sakamoto, K., McCarthy, A., Smith, D., Green, K. A., Grahame Hardie, D., Ashworth, A., Alessi, D. R.

Principal Investigator(s):

2005

Nogo-B is a new physiological substrate for MAPKAP-K2

Rousseau, S., Peggie, M., Campbell, D. G., Nebreda, A. R., Cohen, P.

Principal Investigator(s):

2005

Identification of different specificity requirements between SGK1 and PKBalpha

Murray, J. T., Cummings, L. A., Bloomberg, G. B., Cohen, P.

Principal Investigator(s):

2005

Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart

Mora, A., Sakamoto, K., McManus, E. J., Alessi, D. R.

Principal Investigator(s):

2005

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

Mora, A., Lipina, C., Tronche, F., Sutherland, C., Alessi, D. R.

Principal Investigator(s):

2005

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

McManus, E. J., Sakamoto, K., Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R., Alessi, D. R.

Principal Investigator(s):

2005

Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3

Lipina, C., Huang, X., Finlay, D., McManus, E. J., Alessi, D. R., Sutherland, C.

Principal Investigator(s):

2005

Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding

Komander, D., Kular, G., Deak, M., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):

2005

Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate

Jaleel, M., McBride, A., Lizcano, J. M., Deak, M., Toth, R., Morrice, N. A., Alessi, D. R.

Principal Investigator(s):

2005

Suppressor of cytokine signalling (SOCS)-3 inhibits the beta-cytotoxic IL-1 signalling by targeting the TRAF6/TAK1 complex

Frobose, H., Ronn, S. G., Heding, P. E., Mendoza, H., Cohen, P., Mandrup-Poulsen, T., Billestrup, N.

Principal Investigator(s):

2005

Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damage

Flott, S., Rouse, J.

Principal Investigator(s):

John Rouse

2005

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ

Eyers, C. E., McNeill, H., Knebel, A., Morrice, N., Arthur, S. J., Cuenda, A., Cohen, P.

Principal Investigator(s):

2005

Metformin and reduced risk of cancer in diabetic patients

Evans, J. M., Donnelly, L. A., Emslie-Smith, A. M., Alessi, D. R., Morris, A. D.

Principal Investigator(s):

2005

Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types

Dummler, B. A., Hauge, C., Silber, J., Yntema, H. G., Kruse, L. S., Kofoed, B., Hemmings, B. A., Alessi, D. R., Frodin, M.

Principal Investigator(s):

2005