Protein transformations that change lives

Research | Publications

Foreword - The origins of GSK-3

Cohen, P.

Principal Investigator(s):

2006

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

Vitari, A. C., Thastrup, J., Rafiqi, F. H., Deak, M., Morrice, N. A., Karlsson, H. K., Alessi, D. R.

Principal Investigator(s):

2006

Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62

Stafford, M. J., Morrice, N. A., Peggie, M. W., Cohen, P.

Principal Investigator(s):

2006

Impaired intestinal NHE3 activity in the PDK1 hypomorphic mouse

Sandu, C., Artunc, F., Palmada, M., Rexhepaj, R., Grahammer, F., Hussain, A., Yun, C., Alessi, D. R., Lang, F.

Principal Investigator(s):

2006

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1

Sakamoto, K., Zarrinpashneh, E., Budas, G. R., Pouleur, A. C., Dutta, A., Prescott, A. R., Vanoverschelde, J. L., Ashworth, A., Jovanovic, A., Alessi, D. R., Bertrand, L.

Principal Investigator(s):

2006

CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway

Rousseau, S., Dolado, I., Beardmore, V., Shpiro, N., Marquez, R., Nebreda, A. R., Arthur, J. S., Case, L. M., Tessier-Lavigne, M., Gaestel, M., Cuenda, A., Cohen, P.

Principal Investigator(s):

2006

Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice

Rexhepaj, R., Grahammer, F., Volkl, H., Remy, C., Wagner, C. A., Sandulache, D., Artunc, F., Henke, G., Nammi, S., Capasso, G., Alessi, D. R., Lang, F.

Principal Investigator(s):

2006

Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ

Morton, S., Yang, H. T., Moleleki, N., Campbell, D. G., Cohen, P., Rousseau, S.

Principal Investigator(s):

2006

Characterization of the reversible phosphorylation and activation of ERK8

Klevernic, I. V., Stafford, M. J., Morrice, N., Peggie, M., Morton, S., Cohen, P.

Principal Investigator(s):

2006

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

Jaleel, M., Villa, F., Deak, M., Toth, R., Prescott, A. R., Van Aalten, D. M., Alessi, D. R.

Principal Investigator(s):

2006

Assay of protein kinases using radiolabeled ATP: a protocol

Hastie, C. J., McLauchlan, H. J., Cohen, P.

Principal Investigator(s):

2006

Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation

Goransson, O., Deak, M., Wullschleger, S., Morrice, N. A., Prescott, A. R., Alessi, D. R.

Principal Investigator(s):

2006

Suppressor of cytokine signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex

Frobose, H., Ronn, S. G., Heding, P. E., Mendoza, H., Cohen, P., Mandrup-Poulsen, T., Billestrup, N.

Principal Investigator(s):

2006

KESTREL: a powerful method for identifying the physiological substrates of protein kinases

Cohen, P., Knebel, A.

Principal Investigator(s):

2006

The twentieth century struggle to decipher insulin signalling

Cohen, P.

Principal Investigator(s):

2006

3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium

Budas, G. R., Sukhodub, A., Alessi, D. R., Jovanovic, A.

Principal Investigator(s):

2006

Emerging roles of pseudokinases

Boudeau, J., Miranda-Saavedra, D., Barton, G. J., Alessi, D. R.

Principal Investigator(s):

2006

Evaluation of approaches to generation of tissue-specific knock-in mice

Bayascas, J. R., Sakamoto, K., Armit, L., Arthur, J. S., Alessi, D. R.

Principal Investigator(s):

2006

Impaired intestinal and renal glucose transport in PDK-1 hypomorphic mice

Artunc, F., Rexhepaj, R., Volkl, H., Grahammer, F., Remy, C., Sandulache, D., Nasir, O., Wagner, C. A., Alessi, D. R., Lang, F.

Principal Investigator(s):

2006

LKB1-dependent signaling pathways

Alessi, D. R., Sakamoto, K., Bayascas, J. R.

Principal Investigator(s):

2006