Research | Publications

Year

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

Kulathu, Y., Akutsu, M., Bremm, A., Hofmann, K., Komander, D.

Principal Investigator(s):
Yogesh Kulathu
2009
PubMed

Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling

Gao, S., Alarcon, C., Sapkota, G., Rahman, S., Chen, P. Y., Goerner, N., Macias, M. J., Erdjument-Bromage, H., Tempst, P., Massague, J.

Principal Investigator(s):
Gopal Sapkota
2009
PubMed

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

Ganley, I. G., Lam du, H., Wang, J., Ding, X., Chen, S., Jiang, X.

Principal Investigator(s):
Ian Ganley
2009
PubMed

A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome

Gambus, A., van Deursen, F., Polychronopoulos, D., Foltman, M., Jones, R. C., Edmondson, R. D., Calzada, A., Labib, K.

Principal Investigator(s):
Karim Labib
2009
PubMed

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways

Alarcon, C., Zaromytidou, A. I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A. N., Manova-Todorova, K., Macias, M. J., Sapkota, G., Pan, D., Massague, J.

Principal Investigator(s):
Gopal Sapkota
2009
PubMed

The 450 kDa TCR Complex has a Stoichiometry of alphabetagammaepsilondeltaepsilonzetazeta

Swamy M, Dopfer EP, Molnar E, Alarcón B, Schamel WW.

Principal Investigator(s):
Mahima Swamy
2008
PubMed

The ground state of embryonic stem cell self-renewal

Ying, Q. L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., Smith, A.

Principal Investigator(s):
Philip Cohen
2008
PubMed

IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells

Yang, H. T., Cohen, P., Rousseau, S.

Principal Investigator(s):
Philip Cohen
2008
PubMed

Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase

Windheim, M., Stafford, M., Peggie, M., Cohen, P.

Principal Investigator(s):
Philip Cohen
2008
PubMed

Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology

Windheim, M., Peggie, M., Cohen, P.

Principal Investigator(s):
Philip Cohen
2008
PubMed

Structure of the OSR1 kinase, a hypertension drug target

Villa, F., Deak, M., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):
Dario Alessi
2008
PubMed

Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage

Vazquez-Martin, C., Rouse, J., Cohen, P. T. W.

Principal Investigator(s):
John Rouse
2008
PubMed

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF{alpha} in LPS-stimulated macrophages

Rousseau, S., Papoutsopoulou, M., Symons, A., Cook, D., Lucocq, J. M., Prescott, A. R., O'Garra, A., Ley, S. C., Cohen, P.

Principal Investigator(s):
Philip Cohen
2008
PubMed

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

Richardson, C., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2008
PubMed

Small-molecule inhibitors of PDK1

Peifer, C., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2008
PubMed

The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1

Ordureau, A., Smith, H., Windheim, M., Peggie, M., Carrick, E., Morrice, N., Cohen, P.

Principal Investigator(s):
Philip Cohen
2008
PubMed

Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

Morton, S., Hesson, L., Peggie, M., Cohen, P.

Principal Investigator(s):
Philip Cohen
2008
PubMed

Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

Mendoza, H., Campbell, D. G., Burness, K., Hastie, J., Ronkina, N., Shim, J. H., Arthur, J. S., Davis, R. J., Gaestel, M., Johnson, G. L., Ghosh, S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2008
PubMed

Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer

McCracken, S. R., Ramsay, A., Heer, R., Mathers, M. E., Jenkins, B. L., Edwards, J., Robson, C. N., Marquez, R., Cohen, P., Leung, H. Y.

Principal Investigator(s):
Philip Cohen
2008
PubMed

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

Huang, X., Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., McBurnie, W., Fleming, S., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2008
PubMed