Research | Publications

Year

Butyrophilin-like 1 encodes an enterocyte protein that selectively regulates functional interactions with T lymphocytes.

Bas, A., Swamy, M., Abeler-Dörner, L., Williams, G., Pang, D.J., Barbee, S.D., and Hayday, A.C.

Principal Investigator(s):
Mahima Swamy
2011
PubMed

Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis

Wullschleger, S., Wasserman, D. H., Gray, A., Sakamoto, K., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2011
PubMed

How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance

Wullschleger, S., Sakamoto, K., Johnstone, L., Duce, S., Fleming, S., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2011
PubMed

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations

Woodroof, H. I., Pogson, J. H., Begley, M., Cantley, L. C., Deak, M., Campbell, D. G., van Aalten, D. M., Whitworth, A. J., Alessi, D. R., Muqit, M. M.

Principal Investigator(s):
Dario Alessi, Miratul Muqit
2011
PubMed

The specificities of small molecule inhibitors of the TGFß and BMP pathways

Vogt, J., Traynor, R., Sapkota, G. P.

Principal Investigator(s):
Gopal Sapkota
2011
PubMed

SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

Stoepker, C., Hain, K., Schuster, B., Hilhorst-Hofstee, Y., Rooimans, M. A., Steltenpool, J., Oostra, A. B., Eirich, K., Korthof, E. T., Nieuwint, A. W., Jaspers, N. G., Bettecken, T., Joenje, H., Schindler, D., Rouse, J., de Winter, J. P.

Principal Investigator(s):
John Rouse
2011
PubMed

The role of TBK1 and IKKepsilon in the expression and activation of Pellino 1

Smith, H. L., Liu, X. Y., Dai, L., Goh, E. T., Chan, A. T., Xi, J., Seh, C. C., Qureshi, I. A., Lescar, J., Ruedl, C., Gourlay, R., Morton, S., Hough, J., McIver, E. G., Cohen, P., Cheung, P. C.

Principal Investigator(s):
Philip Cohen
2011
PubMed

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

Richardson, C., Sakamoto, K., de Los Heros, P., Deak, M., Campbell, D. G., Prescott, A. R., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2011
PubMed

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

Pearce, L. R., Sommer, E. M., Sakamoto, K., Wullschleger, S., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2011
PubMed

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

Nanda, S. K., Venigalla, R. K., Ordureau, A., Patterson-Kane, J. C., Powell, D. W., Toth, R., Arthur, J. S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2011
PubMed

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

Najafov, A., Sommer, E. M., Axten, J. M., Deyoung, M. P., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2011
PubMed

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop

Loffler, A. S., Alers, S., Dieterle, A. M., Keppeler, H., Franz-Wachtel, M., Kundu, M., Campbell, D. G., Wesselborg, S., Alessi, D. R., Stork, B.

Principal Investigator(s):
Dario Alessi
2011
PubMed

Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon {beta}

Gleason, C. E., Ordureau, A., Gourlay, R., Arthur, J. S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2011
PubMed

Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice

Garcia-Martinez, J. M., Wullschleger, S., Preston, G., Guichard, S., Fleming, S., Alessi, D. R., Duce, S. L.

Principal Investigator(s):
Dario Alessi
2011
PubMed

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

Filippi, B. M., de Los Heros, P., Mehellou, Y., Navratilova, I., Gourlay, R., Deak, M., Plater, L., Toth, R., Zeqiraj, E., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2011
PubMed

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

Deng, X., Dzamko, N., Prescott, A., Davies, P., Liu, Q., Yang, Q., Lee, J. D., Patricelli, M. P., Nomanbhoy, T. K., Alessi, D. R., Gray, N. S.

Principal Investigator(s):
Dario Alessi
2011
PubMed

The TRAF-associated protein TANK facilitates cross-talk within the I{kappa}B kinase family during Toll-like receptor signaling

Clark, K., Takeuchi, O., Akira, S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2011
PubMed

Novel cross-talk within the IKK family controls innate immunity

Clark, K., Peggie, M., Plater, L., Sorcek, R. J., Young, E. R., Madwed, J. B., Hough, J., McIver, E. G., Cohen, P.

Principal Investigator(s):
Philip Cohen
2011
PubMed

Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade

Chiga, M., Rafiqi, F. H., Alessi, D. R., Sohara, E., Ohta, A., Rai, T., Sasaki, S., Uchida, S.

Principal Investigator(s):
Dario Alessi
2011
PubMed

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2011
PubMed