Research | Publications

Year

DEAF1 Is a Pellino1-interacting Protein Required for Interferon Production by Sendai Virus and Double-stranded RNA

Ordureau, A., Enesa, K., Nanda, S., Le Francois, B., Peggie, M., Prescott, A., Albert, P. R., Cohen, P.

Principal Investigator(s):
Philip Cohen
2013
PubMed

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

Ohta, A., Schumacher, F. R., Mehellou, Y., Johnson, C., Knebel, A., Macartney, T. J., Wood, N. T., Alessi, D. R., Kurz, T.

Principal Investigator(s):
Dario Alessi
2013
PubMed

N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling

Melo, Z., de los Heros, P., Cruz-Rangel, S., Vazquez, N., Bobadilla, N. A., Pasantes-Morales, H., Alessi, D. R., Mercado, A., Gamba, G.

Principal Investigator(s):
Dario Alessi
2013
PubMed

Structural insights into the activation of MST3 by MO25

Mehellou, Y., Alessi, D. R., Macartney, T. J., Szklarz, M., Knapp, S., Elkins, J. M.

Principal Investigator(s):
Dario Alessi
2013
PubMed

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S., Tauro, S.

Principal Investigator(s):
Ian Ganley
2013
PubMed

The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases

Krishnan, N., Bencze, G., Cohen, P., Tonks, N. K.

Principal Investigator(s):
Philip Cohen
2013
PubMed

TAK1 inhibition in the DFG-out conformation

Kilty, I., Green, M. P., Bell, A. S., Brown, D. G., Dodd, P. G., Hewson, C., Hughes, S. J., Phillips, C., Ryckmans, T., Smith, R. T., van Hoorn, W. P., Cohen, P., Jones, L. H.

Principal Investigator(s):
Philip Cohen
2013
PubMed

OTUB1 enhances TGFbeta signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3

Herhaus, L., Al-Salihi, M., Macartney, T., Weidlich, S., Sapkota, G. P.

Principal Investigator(s):
Gopal Sapkota
2013
PubMed

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Hau, A. M., Greenwood, J. A., Lohr, C. V., Serrill, J. D., Proteau, P. J., Ganley, I. G., McPhail, K. L., Ishmael, J. E.

Principal Investigator(s):
Ian Ganley
2013
PubMed

LKB1 and AMPK and the cancer-metabolism link - ten years after

Hardie, D. G., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2013
PubMed

p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia

Groves, M. J., Johnson, C. E., James, J., Prescott, A. R., Cunningham, J., Haydock, S., Pepper, C., Fegan, C., Pirrie, L., Westwood, N. J., Coates, P. J., Ganley, I. G., Tauro, S.

Principal Investigator(s):
Ian Ganley
2013
PubMed

Autophagosome maturation and lysosomal fusion

Ganley, I. G.

Principal Investigator(s):
Ian Ganley
2013
PubMed

TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency

Flinn, L. J., Keatinge, M., Bretaud, S., Mortiboys, H., Matsui, H., De Felice, E., Woodroof, H. I., Brown, L., McTighe, A., Soellner, R., Allen, C. E., Heath, P. R., Milo, M., Muqit, M. M., Reichert, A. S., Koster, R. W., Ingham, P. W., Bandmann, O.

Principal Investigator(s):
Miratul Muqit
2013
PubMed

Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer

Eser, S., et al including Alessi, D. R., Saur, D.

Principal Investigator(s):
Dario Alessi
2013
PubMed

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

Emmerich, C. H., Ordureau, A., Strickson, S., Arthur, J. S., Pedrioli, P. G., Komander, D., Cohen, P.

Principal Investigator(s):
Philip Cohen
2013
PubMed

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

Deng, X., Elkins, J. M., Zhang, J., Yang, Q., Erazo, T., Gomez, N., Choi, H. G., Wang, J., Dzamko, N., Lee, J. D., Sim, T., Kim, N., Alessi, D. R., Lizcano, J. M., Knapp, S., Gray, N. S.

Principal Investigator(s):
Dario Alessi
2013
PubMed

Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation

Delbroek, L., Van Kolen, K., Steegmans, L., da Cunha, R., Mandemakers, W., Daneels, G., De Bock, P. J., Zhang, J., Gevaert, K., De Strooper, B., Alessi, D. R., Verstreken, P., Moechars, D. W.

Principal Investigator(s):
Dario Alessi
2013
PubMed

Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

Davies, P., Hinkle, K. M., Sukar, N. N., Sepulveda, B., Mesias, R., Serrano, G., Alessi, D. R., Beach, T. G., Benson, D. L., White, C. L., Cowell, R. M., Das, S. S., West, A. B., Melrose, H. L.

Principal Investigator(s):
Dario Alessi
2013
PubMed

Kinase Drug Discovery - What's Next in the Field?

Cohen, P., Alessi, D. R.

Principal Investigator(s):
Dario Alessi, Philip Cohen
2013
PubMed

Molecular control of the NEMO family of ubiquitin-binding proteins

Clark, K., Nanda, S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2013
PubMed