Protein transformations that change lives

Research | Publications

PKB/SGK-Resistant GSK-3 Signaling Following Unilateral Ureteral Obstruction

Voelkl, J., Mia, S., Meissner, A., Ahmed, M. S., Feger, M., Elvira, B., Walker, B., Alessi, D. R., Alesutan, I., Lang, F.

Principal Investigator(s):

2013

The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N., Cohen, P.

Principal Investigator(s):

2013

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

Sommer, E. M., Dry, H., Cross, D., Guichard, S., Davies, B. R., Alessi, D. R.

Principal Investigator(s):

2013

The TGFbeta-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1

Sapkota, G. P.

Principal Investigator(s):

2013

Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice

Pauls, E., Nanda, S. K., Smith, H., Toth, R., Arthur, J. S., Cohen, P.

Principal Investigator(s):

2013

DEAF1 Is a Pellino1-interacting Protein Required for Interferon Production by Sendai Virus and Double-stranded RNA

Ordureau, A., Enesa, K., Nanda, S., Le Francois, B., Peggie, M., Prescott, A., Albert, P. R., Cohen, P.

Principal Investigator(s):

2013

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

Ohta, A., Schumacher, F. R., Mehellou, Y., Johnson, C., Knebel, A., Macartney, T. J., Wood, N. T., Alessi, D. R., Kurz, T.

Principal Investigator(s):

2013

N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling

Melo, Z., de los Heros, P., Cruz-Rangel, S., Vazquez, N., Bobadilla, N. A., Pasantes-Morales, H., Alessi, D. R., Mercado, A., Gamba, G.

Principal Investigator(s):

2013

Structural insights into the activation of MST3 by MO25

Mehellou, Y., Alessi, D. R., Macartney, T. J., Szklarz, M., Knapp, S., Elkins, J. M.

Principal Investigator(s):

2013

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S., Tauro, S.

Principal Investigator(s):

2013

The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases

Krishnan, N., Bencze, G., Cohen, P., Tonks, N. K.

Principal Investigator(s):

2013

TAK1 inhibition in the DFG-out conformation

Kilty, I., Green, M. P., Bell, A. S., Brown, D. G., Dodd, P. G., Hewson, C., Hughes, S. J., Phillips, C., Ryckmans, T., Smith, R. T., van Hoorn, W. P., Cohen, P., Jones, L. H.

Principal Investigator(s):

2013

OTUB1 enhances TGFbeta signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3

Herhaus, L., Al-Salihi, M., Macartney, T., Weidlich, S., Sapkota, G. P.

Principal Investigator(s):

2013

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Hau, A. M., Greenwood, J. A., Lohr, C. V., Serrill, J. D., Proteau, P. J., Ganley, I. G., McPhail, K. L., Ishmael, J. E.

Principal Investigator(s):

2013

LKB1 and AMPK and the cancer-metabolism link - ten years after

Hardie, D. G., Alessi, D. R.

Principal Investigator(s):

2013

p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia

Groves, M. J., Johnson, C. E., James, J., Prescott, A. R., Cunningham, J., Haydock, S., Pepper, C., Fegan, C., Pirrie, L., Westwood, N. J., Coates, P. J., Ganley, I. G., Tauro, S.

Principal Investigator(s):

2013

Autophagosome maturation and lysosomal fusion

Ganley, I. G.

Principal Investigator(s):

2013

TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency

Flinn, L. J., Keatinge, M., Bretaud, S., Mortiboys, H., Matsui, H., De Felice, E., Woodroof, H. I., Brown, L., McTighe, A., Soellner, R., Allen, C. E., Heath, P. R., Milo, M., Muqit, M. M., Reichert, A. S., Koster, R. W., Ingham, P. W., Bandmann, O.

Principal Investigator(s):

2013

Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer

Eser, S., et al including Alessi, D. R., Saur, D.

Principal Investigator(s):

2013

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

Emmerich, C. H., Ordureau, A., Strickson, S., Arthur, J. S., Pedrioli, P. G., Komander, D., Cohen, P.

Principal Investigator(s):

2013