Research | Publications

Year

USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death

Liang JR, Martinez A, Lane JD, Mayor U, Clague MJ, Urbé S

Principal Investigator(s):
Jin Rui (Amos) Liang
2015
PubMed

Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance

Swamy M, Abeler-Dörner L, Chettle J, Mahlakõiv T, Goubau D, Chakravarty P, Ramsay G, Reis e Sousa C, Staeheli P, Blacklaws BA, Heeney JL, Hayday AC.

Principal Investigator(s):
Mahima Swamy
2015
PubMed

Phosphorylation of Synaptic Vesicle Protein 2A at Thr84 by Casein Kinase 1 Family Kinases Controls the Specific Retrieval of Synaptotagmin-1

Zhang, N., Gordon, S. L., Fritsch, M. J., Esoof, N., Campbell, D. G., Gourlay, R., Velupillai, S., Macartney, T., Peggie, M., van Aalten, D. M., Cousin, M. A., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2015
PubMed

Critical role of the SPAK protein kinase CCT domain in controlling blood pressure

Zhang, J., Siew, K., Macartney, T., O'Shaughnessy, K. M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2015
PubMed

Discovery of Type II Inhibitors of TGFbeta-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)

Tan, L., Nomanbhoy, T., Gurbani, D., Patricelli, M., Hunter, J., Geng, J., Herhaus, L., Zhang, J., Pauls, E., Ham, Y., Choi, H. G., Xie, T., Deng, X., Buhrlage, S. J., Sim, T., Cohen, P., Sapkota, G., Westover, K. D., Gray, N. S.

Principal Investigator(s):
Philip Cohen, Gopal Sapkota
2015
PubMed

GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling

Stretton, C., Hoffmann, T. M., Munson, M. J., Prescott, A., Taylor, P. M., Ganley, I. G., Hundal, H. S.

Principal Investigator(s):
Ian Ganley
2015
PubMed

Orthogonal Thiol Functionalization at a Single Atomic Center for Profiling Transthiolation Activity of E1 Activating Enzymes

Stanley, M., Han, C., Knebel, A., Murphy, P., Shpiro, N., Virdee, S.

Principal Investigator(s):
Satpal Virdee
2015
PubMed

Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C. elegans Embryos

Sonneville, R., Craig, G., Labib, K., Gartner, A., Blow, J. J.

Principal Investigator(s):
Karim Labib
2015
PubMed

Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9

Rojas-Fernandez, A., Herhaus, L., Macartney, T., Lachaud, C., Hay, R. T., Sapkota, G. P.

Principal Investigator(s):
Gopal Sapkota
2015
PubMed

Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog

Rogerson, D. T., Sachdeva, A., Wang, K., Haq, T., Kazlauskaite, A., Hancock, S. M., Huguenin-Dezot, N., Muqit, M. M., Fry, A. M., Bayliss, R., Chin, J. W.

Principal Investigator(s):
Miratul Muqit
2015
PubMed

Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy

Petherick, K. J., Conway, O. J., Mpamhanga, C., Osborne, S. A., Kamal, A., Saxty, B., Ganley, I. G.

Principal Investigator(s):
Ian Ganley
2015
PubMed

USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses

Perez-Oliva, A. B., Lachaud, C., Szyniarowski, P., Munoz, I., Macartney, T., Hickson, I., Rouse, J., Alessi, D. R.

Principal Investigator(s):
Dario Alessi, John Rouse
2015
PubMed

Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-kappaB and Interferon Signaling: Implications for Paget's Disease

Obaid, R., Wani, S. E., Azfer, A., Hurd, T., Jones, R., Cohen, P., Ralston, S. H., Albagha, O. M.

Principal Investigator(s):
Philip Cohen
2015
PubMed

MTOR, PIK3C3, and autophagy: Signaling the beginning from the end

Munson, M. J., Ganley, I. G.

Principal Investigator(s):
Ian Ganley
2015
PubMed

mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival

Munson, M. J., Allen, G. F., Toth, R., Campbell, D. G., Lucocq, J. M., Ganley, I. G.

Principal Investigator(s):
Ian Ganley
2015
PubMed

The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL

Miles, J. A., Frost, M. G., Carroll, E., Rowe, M. L., Howard, M. J., Sidhu, A., Chaugule, V. K., Alpi, A. F., Walden, H.

2015
PubMed

Suppression of Interferon beta gene transcription by inhibitors of Bromodomain and Extra-Terminal (BET) family members

Malik, N., Vollmer, S., Nanda, S. K., Lopez-Pelaez, M., Prescott, A., Gray, N., Cohen, P.

Principal Investigator(s):
Philip Cohen
2015
PubMed

Tethering of SCF(Dia2) to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase

Maculins, T., Nkosi, P. J., Nishikawa, H., Labib, K.

Principal Investigator(s):
Karim Labib
2015
PubMed

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

Lai, Y. C., Kondapalli, C., Lehneck, R., Procter, J. B., Dill, B. D., Woodroof, H. I., Gourlay, R., Peggie, M., Macartney, T. J., Corti, O., Corvol, J. C., Campbell, D. G., Itzen, A., Trost, M., Muqit, M. M.

Principal Investigator(s):
Miratul Muqit
2015
PubMed

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

Kumar, A., Aguirre, J. D., Condos, T. E., Martinez-Torres, R. J., Chaugule, V. K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D. E., Barber, K. R., Shaw, G. S., Walden, H.

2015
PubMed