Research | Publications

Year

Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL

Auld, G. C., Campbell, D. G., Morrice, N., Cohen, P.

Principal Investigator(s):
Philip Cohen
2005
PubMed

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK

Al-Hakim, A. K., Goransson, O., Deak, M., Toth, R., Campbell, D. G., Morrice, N. A., Prescott, A. R., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2005
PubMed

Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations

Turner, S. J., Kedzierska, K., Komodromou, H., La Gruta, N. L., Dunstone, M. A., Webb, A. I., Webby, R., Walden, H., Xie, W., McCluskey, J., Purcell, A. W., Rossjohn, J., Doherty, P. C.

2005
PubMed

A leucine zipper in the N terminus confers membrane association to SLP-65

Kohler, F., Storch, B., Kulathu, Y., Herzog, S., Kuppig, S., Reth, M., Jumaa, H.

Principal Investigator(s):
Yogesh Kulathu
2005
PubMed

Restraining PI3K: mTOR signalling goes back to the membrane

Harrington, L. S., Findlay, G. M., Lamb, R. F.

Principal Investigator(s):
Greg Findlay
2005
PubMed

TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation?

Findlay, G. M., Harrington, L. S., Lamb, R. F.

Principal Investigator(s):
Greg Findlay
2005
PubMed

Structural analysis of Escherichia coli ThiF

Duda, D. M., Walden, H., Sfondouris, J., Schulman, B. A.

2005
PubMed

Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork

Calzada, A., Hodgson, B., Kanemaki, M., Bueno, A., Labib, K.

Principal Investigator(s):
Karim Labib
2005
PubMed

Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition

Bandopadhyay, R., Kingsbury, A. E., Muqit, M. M., Harvey, K., Reid, A. R., Kilford, L., Engelender, S., Schlossmacher, M. G., Wood, N. W., Latchman, D. S., Harvey, R. J., Lees, A. J.

Principal Investigator(s):
Miratul Muqit
2005
PubMed

Protein kinase inhibitors for the treatment of disease: the promise and the problems

Cohen, P.

Principal Investigator(s):
Philip Cohen
2004
PubMed

Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK)

Yoshida, H., Hastie, C. J., McLauchlan, H., Cohen, P., Goedert, M.

Principal Investigator(s):
Philip Cohen
2004

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

Vitari, A. C., Deak, M., Collins, B. J., Morrice, N., Prescott, A. R., Phelan, A., Humphreys, S., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2004
PubMed

High-Content Peptide Microarrays for Deciphering Kinase Specificity and Biology

Schutkowski, M., Reimer, U., Panse, S. , Dong, L. , Lizcano, J. M., Alessi, D. R., Schneider-Mergener, J.

Principal Investigator(s):
Dario Alessi
2004

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

Sakamoto, K., Goransson, O., Hardie, D. G., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2004
PubMed

Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage

Rouse, J.

Principal Investigator(s):
John Rouse
2004
PubMed

Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways

Rosser, E. M., Morton, S., Ashton, K. S., Cohen, P., Hulme, A. N.

Principal Investigator(s):
Philip Cohen
2004
PubMed

D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a

Rena, G., Bain, J., Elliott, M., Cohen, P.

Principal Investigator(s):
Philip Cohen
2004
PubMed

Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL

Murray, J. T., Campbell, D. G., Peggie, M., Mora, A., Cohen, P.

Principal Investigator(s):
Philip Cohen
2004
PubMed

Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3

Murray, J. T., Campbell, D. G., Morrice, N., Auld, G. C., Shpiro, N., Marquez, R., Peggie, M., Bain, J., Bloomberg, G. B., Grahammer, F., Lang, F., Wulff, P., Kuhl, D., Cohen, P.

Principal Investigator(s):
Philip Cohen
2004
PubMed

Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2

Morton, S., Davis, R. J., Cohen, P.

Principal Investigator(s):
Philip Cohen
2004
PubMed