Protein transformations that change lives

Research | Publications

Regulation of microfilament organization by Kaposi sarcoma-associated herpes virus-cyclin.CDK6 phosphorylation of caldesmon

Cuomo, M. E., Knebel, A., Platt, G., Morrice, N., Cohen, P., Mittnacht, S.

Principal Investigator(s):

2005

In vivo role of the phosphate groove of PDK1 defined by knockin mutation

Collins, B. J., Deak, M., Murray-Tait, V., Storey, K. G., Alessi, D. R.

Principal Investigator(s):

2005

The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells

Cartlidge, R. A., Knebel, A., Peggie, M., Alexandrov, A., Phizicky, E. M., Cohen, P.

Principal Investigator(s):

2005

Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice

Bayascas, J. R., Leslie, N. R., Parsons, R., Fleming, S., Alessi, D. R.

Principal Investigator(s):

2005

Regulation of Akt/PKB Ser473 phosphorylation

Bayascas, J. R., Alessi, D. R.

Principal Investigator(s):

2005

Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL

Auld, G. C., Campbell, D. G., Morrice, N., Cohen, P.

Principal Investigator(s):

2005

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK

Al-Hakim, A. K., Goransson, O., Deak, M., Toth, R., Campbell, D. G., Morrice, N. A., Prescott, A. R., Alessi, D. R.

Principal Investigator(s):

2005

Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations

Turner, S. J., Kedzierska, K., Komodromou, H., La Gruta, N. L., Dunstone, M. A., Webb, A. I., Webby, R., Walden, H., Xie, W., McCluskey, J., Purcell, A. W., Rossjohn, J., Doherty, P. C.

2005

A leucine zipper in the N terminus confers membrane association to SLP-65

Kohler, F., Storch, B., Kulathu, Y., Herzog, S., Kuppig, S., Reth, M., Jumaa, H.

Principal Investigator(s):

2005

Restraining PI3K: mTOR signalling goes back to the membrane

Harrington, L. S., Findlay, G. M., Lamb, R. F.

Principal Investigator(s):

2005

TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation?

Findlay, G. M., Harrington, L. S., Lamb, R. F.

Principal Investigator(s):

2005

Structural analysis of Escherichia coli ThiF

Duda, D. M., Walden, H., Sfondouris, J., Schulman, B. A.

2005

Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork

Calzada, A., Hodgson, B., Kanemaki, M., Bueno, A., Labib, K.

Principal Investigator(s):

2005

Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition

Bandopadhyay, R., Kingsbury, A. E., Muqit, M. M., Harvey, K., Reid, A. R., Kilford, L., Engelender, S., Schlossmacher, M. G., Wood, N. W., Latchman, D. S., Harvey, R. J., Lees, A. J.

Principal Investigator(s):

2005

Protein kinase inhibitors for the treatment of disease: the promise and the problems

Cohen, P.

Principal Investigator(s):

2004

Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK)

Yoshida, H., Hastie, C. J., McLauchlan, H., Cohen, P., Goedert, M.

Principal Investigator(s):

2004

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

Vitari, A. C., Deak, M., Collins, B. J., Morrice, N., Prescott, A. R., Phelan, A., Humphreys, S., Alessi, D. R.

Principal Investigator(s):

2004

High-Content Peptide Microarrays for Deciphering Kinase Specificity and Biology

Schutkowski, M., Reimer, U., Panse, S. , Dong, L. , Lizcano, J. M., Alessi, D. R., Schneider-Mergener, J.

Principal Investigator(s):

2004

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

Sakamoto, K., Goransson, O., Hardie, D. G., Alessi, D. R.

Principal Investigator(s):

2004

Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage

Rouse, J.

Principal Investigator(s):

2004