Kristin Balk, who has been undertaking research in Miratul Muqit’s lab funded by a J Macdonald Menzies Charitable Trust Prize Studentship, has successfully defended her PhD. During her studies Kristin has developed improved methods to study PINK1 signalling in cell lines and applied this to uncover a role for mitochondrial E3 ligases in the generation of Phospho-ubiquitin.
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Sven Lange, a PhD student in the MRC PPU has won The FEBS Journal Poster Prize at "Pseudoenzymes 2018: from molecular mechanism to cell biology" which was held on the island of Sardinia from May 16-19 2018.
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The CK1 family of serine/threonine protein kinases were one of the first kinases to be discovered some 50 years ago, principally because of their incessant ability to phosphorylate the milk protein casein in the test tube.
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The Wnt signalling pathway plays fundamental roles in shaping developing embryos and controlling cell fate in adults. Mutations that cause slight alterations in Wnt signalling are associated with developmental defects as well as a myriad of diseases, such as cancer.
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The ability of cells to move is crucial for many biological processes during development, and for normal tissue growth and repair. Cancer cells can usurp normal cellular processes and make them hyperactive, which leads to inappropriate cell movement that can contribute to metastasis. Understanding the molecular processes that regulate cell migration could uncover novel therapeutic targets against diseases such as cancer. …more
Derailment of the PI3K signalling network contributes to many human diseases including cancer.
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Research by Rosalia Fernandez-Alonso, a post-doctoral investigator in Dr. Greg Findlay’s lab in the MRC PPU, will be published in and featured on the cover of the July edition of the journal EMBO Reports. …more
Please note that the deadline for applying for these projects is 2nd June. These positions are also open to EU and non-EU applicants. It is expected the student would be able to take up the studentship in Autumn 2017. …more
Being able to selectively and rapidly degrade target proteins in cells is desirable in research and therapeutics.
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The Affinity-directed PROtein Missile (AdPROM) system, described by the Sapkota lab in Open Biology, combines the CRISPR/Cas9 genome editing technology and proteolysis to achieve a robust degradation of potentially any endogenous protein in cells. …more