Greg Findlay and Francisco Bustos, a postdoctoral researcher in Greg’s group, were recently awarded a £20,000 Tenovus Scotland Research Grant to engineer an RNF12 E3 ligase substrate degrader as a therapeutic strategy in Tonne-Kalscheuer Syndrome (TOKAS) intellectual disability.
…moreNews
Luke Fulcher, who has just completed his PhD work in Gopal Sapkota’s lab, has been awarded the prestigious University of Dundee School of Life Sciences Howard Elder Prize for 2019.
…more
In MRC PPU we are extremely proud that in 2019, a total of 13 PhD students and 1 MSc student defended their theses, and everyone passed with flying colours! As part of the defence, each student gave a 45-minute talk describing their PhD research, to packed lecture rooms.
…more
The concerted action of several protein kinases helps orchestrate the error-free transition through a mammalian cell division cycle.
…more
Kristin Balk, who has been undertaking research in Miratul Muqit’s lab funded by a J Macdonald Menzies Charitable Trust Prize Studentship, has successfully defended her PhD. During her studies Kristin has developed improved methods to study PINK1 signalling in cell lines and applied this to uncover a role for mitochondrial E3 ligases in the generation of Phospho-ubiquitin.
…more
Sven Lange, a PhD student in the MRC PPU has won The FEBS Journal Poster Prize at "Pseudoenzymes 2018: from molecular mechanism to cell biology" which was held on the island of Sardinia from May 16-19 2018.
…more
The CK1 family of serine/threonine protein kinases were one of the first kinases to be discovered some 50 years ago, principally because of their incessant ability to phosphorylate the milk protein casein in the test tube.
…more
The Wnt signalling pathway plays fundamental roles in shaping developing embryos and controlling cell fate in adults. Mutations that cause slight alterations in Wnt signalling are associated with developmental defects as well as a myriad of diseases, such as cancer.
…more
The ability of cells to move is crucial for many biological processes during development, and for normal tissue growth and repair. Cancer cells can usurp normal cellular processes and make them hyperactive, which leads to inappropriate cell movement that can contribute to metastasis. Understanding the molecular processes that regulate cell migration could uncover novel therapeutic targets against diseases such as cancer. …more
Derailment of the PI3K signalling network contributes to many human diseases including cancer.
…more