Protein transformations that change lives

Research | Publications

TAB3, a new binding partner of the protein kinase TAK1

Cheung, P. C., Nebreda, A. R., Cohen, P.

Principal Investigator(s):

2004

Analysis of the LKB1-STRAD-MO25 complex

Boudeau, J., Scott, J. W., Resta, N., Deak, M., Kieloch, A., Komander, D., Hardie, D. G., Prescott, A. R., van Aalten, D. M., Alessi, D. R.

Principal Investigator(s):

2004

Stimulation of renal Na+ dicarboxylate cotransporter 1 by Na+/H+ exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B

Boehmer, C., Embark, H. M., Bauer, A., Palmada, M., Yun, C. H., Weinman, E. J., Endou, H., Cohen, P., Lahme, S., Bichler, K. H., Lang, F.

Principal Investigator(s):

2004

Structure and function of a regulated archaeal triosephosphate isomerase adapted to high temperature

Walden, H., Taylor, G. L., Lorentzen, E., Pohl, E., Lilie, H., Schramm, A., Knura, T., Stubbe, K., Tjaden, B., Hensel, R.

2004

Triosephosphate isomerase of the hyperthermophile Thermoproteus tenax: thermostability is not everything

Walden, H., Taylor, G., Lilie, H., Knura, T., Hensel, R.

2004

The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus

Theodossis, A., Walden, H., Westwick, E. J., Connaris, H., Lamble, H. J., Hough, D. W., Danson, M. J., Taylor, G. L.

2004

Rapid depletion of budding yeast proteins by fusion to a heat-inducible degron

Sanchez-Diaz, A., Kanemaki, M., Marchesi, V., Labib, K.

Principal Investigator(s):

2004

Ubiquitin-like protein activation

Huang, D. T., Walden, H., Duda, D., Schulman, B. A.

2004

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

Harrington, L. S., Findlay, G. M., Gray, A., Tolkacheva, T., Wigfield, S., Rebholz, H., Barnett, J., Leslie, N. R., Cheng, S., Shepherd, P. R., Gout, I., Downes, C. P., Lamb, R. F.

Principal Investigator(s):

2004

Glycogen Synthase Kinase 3

Cohen, P., Frame, S.

Principal Investigator(s):

2003

The effective use of protein kinase inhibitors

Cohen, P.

Principal Investigator(s):

2003

Role of PDK1 in activating AGC protein kinase

Alessi, D. R.

Principal Investigator(s):

2003

A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun

Morton, S., Davis, R. J., McLaren, A., Cohen, P.

Principal Investigator(s):

2003

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

Mora, A., Davies, A. M., Bertrand, L., Sharif, I., Budas, G. R., Jovanovic, S., Mouton, V., Kahn, C. R., Lucocq, J. M., Gray, G. A., Jovanovic, A., Alessi, D. R.

Principal Investigator(s):

2003

An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro

Mody, N., Campbell, D. G., Morrice, N., Peggie, M., Cohen, P.

Principal Investigator(s):

2003

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

Milburn, C. C., Deak, M., Kelly, S. M., Price, N. C., Alessi, D. R., Van Aalten, D. M.

Principal Investigator(s):

2003

Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B

Lizcano, J. M., Alrubaie, S., Kieloch, A., Deak, M., Leevers, S. J., Alessi, D. R.

Principal Investigator(s):

2003

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

Komander, D., Kular, G. S., Bain, J., Elliott, M., Alessi, D. R., Van Aalten, D. M.

Principal Investigator(s):

2003

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1

Kimber, W. A., Deak, M., Prescott, A. R., Alessi, D. R.

Principal Investigator(s):

2003

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Makela, T. P., Alessi, D. R., Hardie, D. G.

Principal Investigator(s):

2003