Protein transformations that change lives

Research | Publications

The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus

Theodossis, A., Walden, H., Westwick, E. J., Connaris, H., Lamble, H. J., Hough, D. W., Danson, M. J., Taylor, G. L.

Principal Investigator(s):

2004

Rapid depletion of budding yeast proteins by fusion to a heat-inducible degron

Sanchez-Diaz, A., Kanemaki, M., Marchesi, V., Labib, K.

Principal Investigator(s):

2004

Ubiquitin-like protein activation

Huang, D. T., Walden, H., Duda, D., Schulman, B. A.

Principal Investigator(s):

2004

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

Harrington, L. S., Findlay, G. M., Gray, A., Tolkacheva, T., Wigfield, S., Rebholz, H., Barnett, J., Leslie, N. R., Cheng, S., Shepherd, P. R., Gout, I., Downes, C. P., Lamb, R. F.

Principal Investigator(s):

2004

Glycogen Synthase Kinase 3

Cohen, P., Frame, S.

Principal Investigator(s):

2003

The effective use of protein kinase inhibitors

Cohen, P.

Principal Investigator(s):

2003

Role of PDK1 in activating AGC protein kinase

Alessi, D. R.

Principal Investigator(s):

2003

A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun

Morton, S., Davis, R. J., McLaren, A., Cohen, P.

Principal Investigator(s):

2003

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

Mora, A., Davies, A. M., Bertrand, L., Sharif, I., Budas, G. R., Jovanovic, S., Mouton, V., Kahn, C. R., Lucocq, J. M., Gray, G. A., Jovanovic, A., Alessi, D. R.

Principal Investigator(s):

2003

An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro

Mody, N., Campbell, D. G., Morrice, N., Peggie, M., Cohen, P.

Principal Investigator(s):

2003

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

Milburn, C. C., Deak, M., Kelly, S. M., Price, N. C., Alessi, D. R., Van Aalten, D. M.

Principal Investigator(s):

2003

Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B

Lizcano, J. M., Alrubaie, S., Kieloch, A., Deak, M., Leevers, S. J., Alessi, D. R.

Principal Investigator(s):

2003

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

Komander, D., Kular, G. S., Bain, J., Elliott, M., Alessi, D. R., Van Aalten, D. M.

Principal Investigator(s):

2003

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1

Kimber, W. A., Deak, M., Prescott, A. R., Alessi, D. R.

Principal Investigator(s):

2003

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Makela, T. P., Alessi, D. R., Hardie, D. G.

Principal Investigator(s):

2003

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

Greene, M. W., Sakaue, H., Wang, L., Alessi, D. R., Roth, R. A.

Principal Investigator(s):

2003

The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC

Friedrich, B., Feng, Y., Cohen, P., Risler, T., Vandewalle, A., Broer, S., Wang, J., Pearce, D., Lang, F.

Principal Investigator(s):

2003

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

Collins, B. J., Deak, M., Arthur, J. S., Armit, L. J., Alessi, D. R.

Principal Investigator(s):

2003

The past and future of protein phosphatase research

Cohen, P.

Principal Investigator(s):

2003

Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha

Cheung, P. C., Campbell, D. G., Nebreda, A. R., Cohen, P.

Principal Investigator(s):

2003