Protein transformations that change lives

Research | Publications

15-deoxy-Delta(12,14)-prostaglandin J(2) regulates endogenous cot MAPK kinase kinase 1 activity induced by lipopolysaccharide

Caivano, M., Rodriguez, C., Cohen, P., Alemany, S.

Principal Investigator(s):

2003

LKB1, a protein kinase regulating cell proliferation and polarity

Boudeau, J., Sapkota, G., Alessi, D. R.

Principal Investigator(s):

Dario Alessi, Gopal Sapkota

2003

Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients

Boudeau, J., Kieloch, A., Alessi, D. R., Stella, A., Guanti, G., Resta, N.

Principal Investigator(s):

2003

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

Boudeau, J., Deak, M., Lawlor, M. A., Morrice, N. A., Alessi, D. R.

Principal Investigator(s):

2003

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Boudeau, J., Baas, A. F., Deak, M., Morrice, N. A., Kieloch, A., Schutkowski, M., Prescott, A. R., Clevers, H. C., Alessi, D. R.

Principal Investigator(s):

2003

Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A

Boehmer, C., Wilhelm, V., Palmada, M., Wallisch, S., Henke, G., Brinkmeier, H., Cohen, P., Pieske, B., Lang, F.

Principal Investigator(s):

2003

The specificities of protein kinase inhibitors: an update

Bain, J., McLauchlan, H., Elliott, M., Cohen, P.

Principal Investigator(s):

2003

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

Baas, A. F., Boudeau, J., Sapkota, G. P., Smit, L., Medema, R., Morrice, N. A., Alessi, D. R., Clevers, H. C.

Principal Investigator(s):

Dario Alessi, Gopal Sapkota

2003

Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8

Walden, H., Podgorski, M. S., Schulman, B. A.

Principal Investigator(s):

2003

The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1

Walden, H., Podgorski, M. S., Huang, D. T., Miller, D. W., Howard, R. J., Minor, D. L., Jr., Holton, J. M., Schulman, B. A.

Principal Investigator(s):

2003

Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo

Kanemaki, M., Sanchez-Diaz, A., Gambus, A., Labib, K.

Principal Investigator(s):

2003

Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs

Zhang, H., Zha, X., Tan, Y., Hornbeck, P. V., Mastrangelo, A. J., Alessi, D. R., Polakiewicz, R. D., Comb, M. J.

Principal Investigator(s):

2002

The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1

Yun, C. C., Palmada, M., Embark, H. M., Fedorenko, O., Feng, Y. X., Henke, G., Setiawan, I., Boehmer, C., Weinman, E. J., Sandrasagra, S., Korbmacher, C., Cohen, P., Pearce, D., Lang, F.

Principal Investigator(s):

2002

MSK1 and MSK2 are required for the mitogen-and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

Wiggin, G. R., Soloaga, A., Foster, J. M., Murray-Tait, V., Cohen, P., Arthur, J. S. C.

Principal Investigator(s):

2002

MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

Wiggin, G. R., Soloaga, A., Foster, J. M., Murray-Tait, V., Cohen, P., Arthur, J. S.

Principal Investigator(s):

2002

Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin

Velasco, G., Armstrong, C., Morrice, N., Frame, S., Cohen, P.

Principal Investigator(s):

2002

Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons

Trotter, L., Panton, W., Hajimohamadreza, I., Petalidis, L., Ward, R., Fleming, Y., Armstrong, C. G., Cohen, P., Karran, E. H., Kinloch, R. A.

Principal Investigator(s):

2002

Phosphorylation of tyrosine hydroxylase in isolated mice adrenal glands

Toska, K., Kleppe, R., Cohen, P., Haavik, J.

Principal Investigator(s):

2002

Regulation of tyrosine hydroxylase by stress-activated protein kinases

Toska, K., Kleppe, R., Armstrong, C. G., Morrice, N. A., Cohen, P., Haavik, J.

Principal Investigator(s):

2002

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

Thomas, C. C., Deak, M., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):

2002