Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

2002

Protein lipid overlay assay

Dowler, S., Kular, G., Alessi, D. R.

Principal Investigator(s):

2002

Dario Alessi, Gopal Sapkota

Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

Douglas, P., Sapkota, G. P., Morrice, N., Yu, Y., Goodarzi, A. A., Merkle, D., Meek, K., Alessi, D. R., Lees-Miller, S. P.

Principal Investigator(s):

2002

The origins of protein phosphorylation

Cohen, P.

Principal Investigator(s):

2002

Protein kinases--the major drug targets of the twenty-first century?

Cohen, P.

Principal Investigator(s):

2002

Drug use and the risk of major depressive disorder, alcohol dependence, and substance use disorders

Brook, D. W., Brook, J. S., Zhang, C. S., Cohen, P., Whiteman, M.

Principal Investigator(s):

2002

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

Biondi, R. M., Komander, D., Thomas, C. C., Lizcano, J. M., Deak, M., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):

2002

Premarital cohabitation and housework: Couples in cross-national perspective

Batalova, J. A., Cohen, P. N.

Principal Investigator(s):

2002

Efficacy of the anti-TNF-alpha antibody infliximab against refractory systemic vasculitides: an open pilot study on 10 patients

Bartolucci, P., Ramanoelina, J., Cohen, P., Mahr, A., Godmer, P., Le Hello, C., Guillevin, L.

Principal Investigator(s):

2002

Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo

Rouse, J., Jackson, S. P.

Principal Investigator(s):

John Rouse

2002

Interfaces between the detection, signaling, and repair of DNA damage

Rouse, J., Jackson, S. P.

Principal Investigator(s):

John Rouse

2002

The chromosome replication cycle

Diffley, J. F., Labib, K.

Principal Investigator(s):

Karim Labib

2002

A minimal cytoplasmic subdomain of the erythropoietin receptor mediates p70 S6 kinase phosphorylation

Zhang, M. Y., Barber, D. L., Alessi, D. R., Bell, L. L., Stine, C., Nguyen, M. H., Beattie, B. K., Cheung, J. Y., Miller, B. A.

Principal Investigator(s):

2001

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

Woods, Y. L., Rena, G., Morrice, N., Barthel, A., Becker, W., Guo, S., Unterman, T. G., Cohen, P.

Principal Investigator(s):

2001

The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

Woods, Y. L., Cohen, P., Becker, W., Jakes, R., Goedert, M., Wang, X., Proud, C. G.

Principal Investigator(s):

2001

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase

Wang, X., Li, W., Williams, M., Terada, N., Alessi, D. R., Proud, C. G.

Principal Investigator(s):

2001

Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity

Thomas, C. C., Dowler, S., Deak, M., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):

2001

Dario Alessi, Gopal Sapkota

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

Sapkota, G. P., Kieloch, A., Lizcano, J. M., Lain, S., Arthur, J. S., Williams, M. R., Morrice, N., Deak, M., Alessi, D. R.

Principal Investigator(s):

2001

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

Rena, G., Prescott, A. R., Guo, S., Cohen, P., Unterman, T. G.

Principal Investigator(s):

2001

Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells

Mora, A., Sabio, G., Gonzalez-Polo, R. A., Cuenda, A., Alessi, D. R., Alonso, J. C., Fuentes, J. M., Soler, G., Centeno, F.

Principal Investigator(s):

2001