Research | Publications

Year

Drug use and the risk of major depressive disorder, alcohol dependence, and substance use disorders

Brook, D. W., Brook, J. S., Zhang, C. S., Cohen, P., Whiteman, M.

Principal Investigator(s):
Philip Cohen
2002

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

Biondi, R. M., Komander, D., Thomas, C. C., Lizcano, J. M., Deak, M., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):
Dario Alessi
2002
PubMed

Premarital cohabitation and housework: Couples in cross-national perspective

Batalova, J. A., Cohen, P. N.

Principal Investigator(s):
Philip Cohen
2002

Efficacy of the anti-TNF-alpha antibody infliximab against refractory systemic vasculitides: an open pilot study on 10 patients

Bartolucci, P., Ramanoelina, J., Cohen, P., Mahr, A., Godmer, P., Le Hello, C., Guillevin, L.

Principal Investigator(s):
Philip Cohen
2002

Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo

Rouse, J., Jackson, S. P.

Principal Investigator(s):
John Rouse
2002
PubMed

Interfaces between the detection, signaling, and repair of DNA damage

Rouse, J., Jackson, S. P.

Principal Investigator(s):
John Rouse
2002
PubMed

The chromosome replication cycle

Diffley, J. F., Labib, K.

Principal Investigator(s):
Karim Labib
2002
PubMed

A minimal cytoplasmic subdomain of the erythropoietin receptor mediates p70 S6 kinase phosphorylation

Zhang, M. Y., Barber, D. L., Alessi, D. R., Bell, L. L., Stine, C., Nguyen, M. H., Beattie, B. K., Cheung, J. Y., Miller, B. A.

Principal Investigator(s):
Dario Alessi
2001
PubMed

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

Woods, Y. L., Rena, G., Morrice, N., Barthel, A., Becker, W., Guo, S., Unterman, T. G., Cohen, P.

Principal Investigator(s):
Philip Cohen
2001
PubMed

The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

Woods, Y. L., Cohen, P., Becker, W., Jakes, R., Goedert, M., Wang, X., Proud, C. G.

Principal Investigator(s):
Philip Cohen
2001
PubMed

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase

Wang, X., Li, W., Williams, M., Terada, N., Alessi, D. R., Proud, C. G.

Principal Investigator(s):
Dario Alessi
2001
PubMed

Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity

Thomas, C. C., Dowler, S., Deak, M., Alessi, D. R., van Aalten, D. M.

Principal Investigator(s):
Dario Alessi
2001
PubMed

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

Sapkota, G. P., Kieloch, A., Lizcano, J. M., Lain, S., Arthur, J. S., Williams, M. R., Morrice, N., Deak, M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi, Gopal Sapkota
2001
PubMed

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

Rena, G., Prescott, A. R., Guo, S., Cohen, P., Unterman, T. G.

Principal Investigator(s):
Philip Cohen
2001
PubMed

Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells

Mora, A., Sabio, G., Gonzalez-Polo, R. A., Cuenda, A., Alessi, D. R., Alonso, J. C., Fuentes, J. M., Soler, G., Centeno, F.

Principal Investigator(s):
Dario Alessi
2001
PubMed

Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway

Mody, N., Leitch, J., Armstrong, C., Dixon, J., Cohen, P.

Principal Investigator(s):
Philip Cohen
2001
PubMed

Antiischemic effects of SB203580 are mediated through the inhibition of p38 alpha mitogen-activated protein kinase - Evidence from ectopic expression of an inhibition-resistant kinase

Martin, J. L., Avkiran, M., Quinlan, R. A., Cohen, P., Marber, M. S.

Principal Investigator(s):
Philip Cohen
2001

Phosphoinositide-regulated kinases and phosphoinositide phosphatases

Leslie, N. R., Biondi, R. M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2001
PubMed

PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

Lawlor, M. A., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2001
PubMed

Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms

Lang, F., Cohen, P.

Principal Investigator(s):
Philip Cohen
2001
PubMed