Research | Publications

Year

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1

Balendran, A., Biondi, R. M., Cheung, P. C., Casamayor, A., Deak, M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2000
PubMed

MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells

Arthur, J. S. C., Cohen, P.

Principal Investigator(s):
Philip Cohen
2000

DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p

Tercero, J. A., Labib, K., Diffley, J. F.

Principal Investigator(s):
Karim Labib
2000
PubMed

LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae

Rouse, J., Jackson, S. P.

Principal Investigator(s):
John Rouse
2000
PubMed

Uninterrupted MCM2-7 function required for DNA replication fork progression

Labib, K., Tercero, J. A., Diffley, J. F.

Principal Investigator(s):
Karim Labib
2000
PubMed

Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18

Kearsey, S. E., Montgomery, S., Labib, K., Lindner, K.

Principal Investigator(s):
Karim Labib
2000
PubMed

A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls

Grallert, B., Kearsey, S. E., Lenhard, M., Carlson, C. R., Nurse, P., Boye, E., Labib, K.

Principal Investigator(s):
Karim Labib
2000
PubMed

Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase

Godber, B. L., Doel, J. J., Sapkota, G. P., Blake, D. R., Stevens, C. R., Eisenthal, R., Harrison, R.

Principal Investigator(s):
Gopal Sapkota
2000
PubMed

Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast

Diffley, J. F., Bousset, K., Labib, K., Noton, E. A., Santocanale, C., Tercero, J. A.

Principal Investigator(s):
Karim Labib
2000
PubMed

MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells

Arthur, J. S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2000
PubMed

Nuclear organisation of NIPP1, a regulatory subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors

Trinkle-Mulcahy, L., Ajuh, P., Prescott, A., Claverie-Martin, F., Cohen, S., Lamond, A. I., Cohen, P.

Principal Investigator(s):
Philip Cohen
1999
PubMed

A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin

Thomas, G. M., Frame, S., Goedert, M., Nathke, I., Polakis, P., Cohen, P.

Principal Investigator(s):
Philip Cohen
1999
PubMed

Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells

Shaw, M., Cohen, P.

Principal Investigator(s):
Philip Cohen
1999
PubMed

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

Rena, G., Guo, S., Cichy, S. C., Unterman, T. G., Cohen, P.

Principal Investigator(s):
Philip Cohen
1999
PubMed

Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide-mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages

Paul, A., Cuenda, A., Bryant, C. E., Murray, J., Chilvers, E. R., Cohen, P., Gould, G. W., Plevin, R.

Principal Investigator(s):
Philip Cohen
1999

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation

Nave, B. T., Ouwens, M., Withers, D. J., Alessi, D. R., Shepherd, P. R.

Principal Investigator(s):
Dario Alessi
1999
PubMed

Activation of the neutrophil NADPH oxidase is inhibited by SB 203580, a specific inhibitor of SAPK2/p38

Lal, A. S., Clifton, A. D., Rouse, J., Segal, A. W., Cohen, P.

Principal Investigator(s):
Philip Cohen, John Rouse
1999
PubMed

Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway

Kovarik, P., Stoiber, D., Eyers, P. A., Menghini, R., Neininger, A., Gaestel, M., Cohen, P., Decker, T.

Principal Investigator(s):
Philip Cohen
1999

Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase

Kobayashi, T., Deak, M., Morrice, N., Cohen, P.

Principal Investigator(s):
Philip Cohen
1999
PubMed

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

Kobayashi, T., Cohen, P.

Principal Investigator(s):
Philip Cohen
1999
PubMed