Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

Origins of the Wellcome Trust Building

Cohen, P.

Principal Investigator(s):

1996

Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography

Moorhead, G., MacKintosh, C., Morrice, N., Cohen, P.

Principal Investigator(s):

1995

The Activation of Distinct Mitogen-Activated Protein-Kinase Cascades Is Required for the Stimulation of 2-Deoxyglucose Uptake by Interleukin-1 and Insulin-Like Growth-Factor-I in Kb Cells

Gould, G. W., Cuenda, A., Thomson, F. J., Cohen, P.

Principal Investigator(s):

1995

Molecular dissection of the paired helical filament

Goedert, M., Spillantini, M.G., Jakes, R., Crowther, R.A., Cohen, P., Vanmechelen, E., Probst, A., G̦tz, J., B�_rki, K.

Principal Investigator(s):

1995

Tau protein in Alzheimer's disease

Goedert, M., Jakes, R., Spillantini, M. G., Crowther, R.A., Cohen, P., Vanmechelen, E., Probst, A., Götz J, Bürki K., K.

Principal Investigator(s):

1995

Protein Phosphatase 2a Is the Major Enzyme in Brain That Dephosphorylates Tau-Protein Phosphorylated by Proline-Directed Protein-Kinases or Cyclic-Amp-Dependent Protein-Kinase

Goedert, M., Jakes, R., Qi, Z., Wang, J. H., Cohen, P.

Principal Investigator(s):

1995

Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells

Doza, Y. N., Cuenda, A., Thomas, G. M., Cohen, P., Nebreda, A. R.

Principal Investigator(s):

1995

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

Cuenda, A., Rouse, J., Doza, Y. N., Meier, R., Cohen, P., Gallagher, T. F., Young, P. R., Lee, J. C.

Principal Investigator(s):

Philip Cohen, John Rouse

1995

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovich, M., Hemmings, B. A.

Principal Investigator(s):

1995

Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2

Ben-Levy, R., Leighton, I. A., Doza, Y. N., Attwood, P., Morrice, N., Marshall, C. J., Cohen, P.

Principal Investigator(s):

1995

Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A). Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells

Baxter, R. M., Cohen, P., Obermeier, A., Ullrich, A., Downes, C. P., Doza, Y. N.

Principal Investigator(s):

1995

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

Alessi, D. R., Gomez, N., Moorhead, G., Lewis, T., Keyse, S. M., Cohen, P.

Principal Investigator(s):

1995

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., Saltiel, A. R.

Principal Investigator(s):

1995

Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

Alessi, D. R., Cohen, P., Ashworth, A., Cowley, S., Leevers, S. J., Marshall, C. J.

Principal Investigator(s):

1995

Interaction of cdc2 and rum1 regulates Start and S-phase in fission yeast

Labib, K., Moreno, S., Nurse, P.

Principal Investigator(s):

Karim Labib

1995

Dominant mutants identify new roles for p34cdc2 in mitosis

Labib, K., Craven, R. A., Crawford, K., Nurse, P.

Principal Investigator(s):

Karim Labib

1995

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

Traverse, S., Seedorf, K., Paterson, H., Marshall, C. J., Cohen, P., Ullrich, A.

Principal Investigator(s):

1994

Identification of a latent MAP kinase kinase kinase in PC12 cells as B-raf

Traverse, S., Cohen, P.

Principal Investigator(s):

1994

The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro

Sutherland, C., Cohen, P.

Principal Investigator(s):

1994