Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

1998

Protein kinase B mediates the insulin induced increase in glucose and amino acid uptake in L6 myotubes

Hajduch, E. , Alessi, D. R., Hemmings, B. A., Hundal, H.

Principal Investigator(s):

1998

Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

Eyers, P. A., Craxton, M., Morrice, N., Cohen, P., Goedert, M.

Principal Investigator(s):

1998

Arsenite blocks growth factor induced activation of the MAP kinase cascade, upstream of Ras and downstream of Grb2-Sos

Doza, Y. N., Hall-Jackson, C. A., Cohen, P.

Principal Investigator(s):

1998

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

Deak, M., Clifton, A. D., Lucocq, L. M., Alessi, D. R.

Principal Investigator(s):

1998

Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK

Dalby, K. N., Morrice, N., Caudwell, F. B., Avruch, J., Cohen, P.

Principal Investigator(s):

1998

Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid

Cohen, P., Goedert, M.

Principal Investigator(s):

1998

The P in protein

Cohen, P.

Principal Investigator(s):

1998

The Department of Biochemistry at the University of Dundee

Cohen, P.

Principal Investigator(s):

1998

Nerve growth factor promotes activation of the alpha, beta and gamma isoforms of protein kinase B in PC12 pheochromocytoma cells

Andjelkovic, M., Suidan, H. S., Meier, R., Frech, M., Alessi, D. R., Hemmings, B. A.

Principal Investigator(s):

1998

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

Alessi, D. R., Kozlowski, M. T., Weng, Q. P., Morrice, N., Avruch, J.

Principal Investigator(s):

1998

The role of PI 3-kinase in insulin action

Alessi, D. R., Downes, C. P.

Principal Investigator(s):

1998

Dario Alessi, Philip Cohen

Mechanism of activation and function of protein kinase B

Alessi, D. R., Cohen, P.

Principal Investigator(s):

1998

MCM proteins: evolution, properties, and role in DNA replication

Kearsey, S. E., Labib, K.

Principal Investigator(s):

Karim Labib

1998

Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells

Thomas, G., Haavik, J., Cohen, P.

Principal Investigator(s):

1997

Radiation and stress-induced apoptosis: A role for Fas/Fas ligand interactions

Reap, E. A., Roof, K., Maynor, K., Borrero, M., Booker, J., Cohen, P. L.

Principal Investigator(s):

1997

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

Meier, R., Alessi, D. R., Cron, P., Andjelkovic, M., Hemmings, B. A.

Principal Investigator(s):

1997

The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells

Macfarlane, W. M., Smith, S. B., James, R. F. L., Clifton, A. D., Doza, Y. N., Cohen, P., Docherty, K.

Principal Investigator(s):

1997

SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK)

Lawler, S., Cuenda, A., Goedert, M., Cohen, P.

Principal Investigator(s):

1997

Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity

Kreivi, J. P., Trinkle-Mulcahy, L., Lyon, C. E., Morrice, N. A., Cohen, P., Lamond, A. I.

Principal Investigator(s):