Research | Publications

Year

Nerve growth factor promotes activation of the alpha, beta and gamma isoforms of protein kinase B in PC12 pheochromocytoma cells

Andjelkovic, M., Suidan, H. S., Meier, R., Frech, M., Alessi, D. R., Hemmings, B. A.

Principal Investigator(s):
Dario Alessi
1998
PubMed

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

Alessi, D. R., Kozlowski, M. T., Weng, Q. P., Morrice, N., Avruch, J.

Principal Investigator(s):
Dario Alessi
1998
PubMed

The role of PI 3-kinase in insulin action

Alessi, D. R., Downes, C. P.

Principal Investigator(s):
Dario Alessi
1998
PubMed

Mechanism of activation and function of protein kinase B

Alessi, D. R., Cohen, P.

Principal Investigator(s):
Dario Alessi, Philip Cohen
1998
PubMed

MCM proteins: evolution, properties, and role in DNA replication

Kearsey, S. E., Labib, K.

Principal Investigator(s):
Karim Labib
1998
PubMed

Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells

Thomas, G., Haavik, J., Cohen, P.

Principal Investigator(s):
Philip Cohen
1997
PubMed

Radiation and stress-induced apoptosis: A role for Fas/Fas ligand interactions

Reap, E. A., Roof, K., Maynor, K., Borrero, M., Booker, J., Cohen, P. L.

Principal Investigator(s):
Philip Cohen
1997

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

Meier, R., Alessi, D. R., Cron, P., Andjelkovic, M., Hemmings, B. A.

Principal Investigator(s):
Dario Alessi
1997
PubMed

The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells

Macfarlane, W. M., Smith, S. B., James, R. F. L., Clifton, A. D., Doza, Y. N., Cohen, P., Docherty, K.

Principal Investigator(s):
Philip Cohen
1997

SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK)

Lawler, S., Cuenda, A., Goedert, M., Cohen, P.

Principal Investigator(s):
Philip Cohen
1997
PubMed

Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity

Kreivi, J. P., Trinkle-Mulcahy, L., Lyon, C. E., Morrice, N. A., Cohen, P., Lamond, A. I.

Principal Investigator(s):
Philip Cohen
1997

Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli

Hazzalin, C. A., Cuenda, A., Cano, E., Cohen, P., Mahadevan, L. C.

Principal Investigator(s):
Philip Cohen
1997

Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases

Goedert, M., Hasegawa, M., Jakes, R., Lawler, S., Cuenda, A., Cohen, P.

Principal Investigator(s):
Philip Cohen
1997

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); Comparison of its substrate specificity with that of other SAP kinases

Goedert, M., Cuenda, A., Craxton, M., Jakes, R., Cohen, P.

Principal Investigator(s):
Philip Cohen
1997

Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades

Deprez, J., Vertommen, D., Alessi, D. R., Hue, L., Rider, M. H.

Principal Investigator(s):
Dario Alessi
1997
PubMed

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

Cuenda, A., Cohen, P., Buee-Scherrer, V., Goedert, M.

Principal Investigator(s):
Philip Cohen
1997
PubMed

Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue

Cross, D. A. E., Watt, P. W., Shaw, M., vanderKaay, J., Downes, C. P., Holder, J. C., Cohen, P.

Principal Investigator(s):
Philip Cohen
1997

PDK1, one of the missing links in insulin signal transduction?

Cohen, P., Alessi, D. R., Cross, D. A.

Principal Investigator(s):
Dario Alessi, Philip Cohen
1997
PubMed

The search for physiological substrates of MAP and SAP kinases in mammalian cells

Cohen, P.

Principal Investigator(s):
Philip Cohen
1997

Role of translocation in the activation and function of protein kinase B

Andjelkovic, M., Alessi, D. R., Meier, R., Fernandez, A., Lamb, N. J., Frech, M., Cron, P., Cohen, P., Lucocq, J. M., Hemmings, B. A.

Principal Investigator(s):
Dario Alessi, Philip Cohen
1997
PubMed