Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

1999

G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus

Labib, K., Diffley, J. F., Kearsey, S. E.

Principal Investigator(s):

Karim Labib

1999

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

Walker, K. S., Deak, M., Paterson, A., Hudson, K., Cohen, P., Alessi, D. R.

Principal Investigator(s):

1998

The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

Shaw, M., Cohen, P., Alessi, D. R.

Principal Investigator(s):

1998

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

Le Good, J. A., Ziegler, W. H., Parekh, D. B., Alessi, D. R., Cohen, P., Parker, P. J.

Principal Investigator(s):

1998

Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro

Lawler, S., Fleming, Y., Goedert, M., Cohen, P.

Principal Investigator(s):

1998

Protein kinase B mediates the insulin induced increase in glucose and amino acid uptake in L6 myotubes

Hajduch, E. , Alessi, D. R., Hemmings, B. A., Hundal, H.

Principal Investigator(s):

1998

Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

Eyers, P. A., Craxton, M., Morrice, N., Cohen, P., Goedert, M.

Principal Investigator(s):

1998

Arsenite blocks growth factor induced activation of the MAP kinase cascade, upstream of Ras and downstream of Grb2-Sos

Doza, Y. N., Hall-Jackson, C. A., Cohen, P.

Principal Investigator(s):

1998

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

Deak, M., Clifton, A. D., Lucocq, L. M., Alessi, D. R.

Principal Investigator(s):

1998

Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK

Dalby, K. N., Morrice, N., Caudwell, F. B., Avruch, J., Cohen, P.

Principal Investigator(s):

1998

Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid

Cohen, P., Goedert, M.

Principal Investigator(s):

1998

The P in protein

Cohen, P.

Principal Investigator(s):

1998

The Department of Biochemistry at the University of Dundee

Cohen, P.

Principal Investigator(s):

1998

Nerve growth factor promotes activation of the alpha, beta and gamma isoforms of protein kinase B in PC12 pheochromocytoma cells

Andjelkovic, M., Suidan, H. S., Meier, R., Frech, M., Alessi, D. R., Hemmings, B. A.

Principal Investigator(s):

1998

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

Alessi, D. R., Kozlowski, M. T., Weng, Q. P., Morrice, N., Avruch, J.

Principal Investigator(s):

1998

The role of PI 3-kinase in insulin action

Alessi, D. R., Downes, C. P.

Principal Investigator(s):

1998

Mechanism of activation and function of protein kinase B

Alessi, D. R., Cohen, P.

Principal Investigator(s):

1998

MCM proteins: evolution, properties, and role in DNA replication

Kearsey, S. E., Labib, K.

Principal Investigator(s):

Karim Labib

1998

Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells

Thomas, G., Haavik, J., Cohen, P.

Principal Investigator(s):

1997