Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

1995

Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells

Doza, Y. N., Cuenda, A., Thomas, G. M., Cohen, P., Nebreda, A. R.

Principal Investigator(s):

1995

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

Cuenda, A., Rouse, J., Doza, Y. N., Meier, R., Cohen, P., Gallagher, T. F., Young, P. R., Lee, J. C.

Principal Investigator(s):

Philip Cohen, John Rouse

1995

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovich, M., Hemmings, B. A.

Principal Investigator(s):

1995

Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2

Ben-Levy, R., Leighton, I. A., Doza, Y. N., Attwood, P., Morrice, N., Marshall, C. J., Cohen, P.

Principal Investigator(s):

1995

Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A). Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells

Baxter, R. M., Cohen, P., Obermeier, A., Ullrich, A., Downes, C. P., Doza, Y. N.

Principal Investigator(s):

1995

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

Alessi, D. R., Gomez, N., Moorhead, G., Lewis, T., Keyse, S. M., Cohen, P.

Principal Investigator(s):

1995

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., Saltiel, A. R.

Principal Investigator(s):

1995

Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

Alessi, D. R., Cohen, P., Ashworth, A., Cowley, S., Leevers, S. J., Marshall, C. J.

Principal Investigator(s):

1995

Interaction of cdc2 and rum1 regulates Start and S-phase in fission yeast

Labib, K., Moreno, S., Nurse, P.

Principal Investigator(s):

Karim Labib

1995

Dominant mutants identify new roles for p34cdc2 in mitosis

Labib, K., Craven, R. A., Crawford, K., Nurse, P.

Principal Investigator(s):

Karim Labib

1995

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

Traverse, S., Seedorf, K., Paterson, H., Marshall, C. J., Cohen, P., Ullrich, A.

Principal Investigator(s):

1994

Identification of a latent MAP kinase kinase kinase in PC12 cells as B-raf

Traverse, S., Cohen, P.

Principal Investigator(s):

1994

The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro

Sutherland, C., Cohen, P.

Principal Investigator(s):

1994

THE ALPHA-ISOFORM OF GLYCOGEN-SYNTHASE KINASE-3 FROM RABBIT SKELETAL-MUSCLE IS INACTIVATED BY P70 S6 KINASE OR MAP KINASE-ACTIVATED PROTEIN KINASE-1 IN-VITRO

Sutherland, C., Cohen, P.

Principal Investigator(s):

1994

Oxidative stress and heat shock induce the expression of the human CL100 gene, which encodes a dual specificity (Thr/Tyr) MAP kinase phosphatase

Sneddon, A. A., Lewis, T. A. , Smythe, C. , Alessi, D. R., Keyse, S. M.

Principal Investigator(s):

Dario Alessi

1994

The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells

Saito, Y., Vandenheede, J. R., Cohen, P.

Principal Investigator(s):

1994

THE MECHANISM BY WHICH EPIDERMAL GROWTH-FACTOR INHIBITS GLYCOGEN-SYNTHASE KINASE 3 IN A431 CELLS

Saito, Y., Vandenheede, J. R., Cohen, P.

Principal Investigator(s):

1994

The threonine residues in MAP kinase kinase 1 phosphorylated by MAP kinase in vitro are also phosphorylated in nerve growth factor-stimulated rat phaeochromocytoma (PC12) cells

Saito, Y., Gomez, N., Campbell, D. G., Ashworth, A., Marshall, C. J., Cohen, P.

Principal Investigator(s):

1994

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T., Nebreda, A. R.

Principal Investigator(s):

Philip Cohen, John Rouse

1994