Protein transformations that change lives

Research | Publications

Radiation and stress-induced apoptosis: A role for Fas/Fas ligand interactions

Reap, E. A., Roof, K., Maynor, K., Borrero, M., Booker, J., Cohen, P. L.

Principal Investigator(s):

1997

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

Meier, R., Alessi, D. R., Cron, P., Andjelkovic, M., Hemmings, B. A.

Principal Investigator(s):

1997

The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells

Macfarlane, W. M., Smith, S. B., James, R. F. L., Clifton, A. D., Doza, Y. N., Cohen, P., Docherty, K.

Principal Investigator(s):

1997

SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK)

Lawler, S., Cuenda, A., Goedert, M., Cohen, P.

Principal Investigator(s):

1997

Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity

Kreivi, J. P., Trinkle-Mulcahy, L., Lyon, C. E., Morrice, N. A., Cohen, P., Lamond, A. I.

Principal Investigator(s):

1997

Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli

Hazzalin, C. A., Cuenda, A., Cano, E., Cohen, P., Mahadevan, L. C.

Principal Investigator(s):

1997

Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases

Goedert, M., Hasegawa, M., Jakes, R., Lawler, S., Cuenda, A., Cohen, P.

Principal Investigator(s):

1997

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); Comparison of its substrate specificity with that of other SAP kinases

Goedert, M., Cuenda, A., Craxton, M., Jakes, R., Cohen, P.

Principal Investigator(s):

1997

Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades

Deprez, J., Vertommen, D., Alessi, D. R., Hue, L., Rider, M. H.

Principal Investigator(s):

1997

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

Cuenda, A., Cohen, P., Buee-Scherrer, V., Goedert, M.

Principal Investigator(s):

1997

Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue

Cross, D. A. E., Watt, P. W., Shaw, M., vanderKaay, J., Downes, C. P., Holder, J. C., Cohen, P.

Principal Investigator(s):

1997

PDK1, one of the missing links in insulin signal transduction?

Cohen, P., Alessi, D. R., Cross, D. A.

Principal Investigator(s):

Dario Alessi, Philip Cohen

1997

The search for physiological substrates of MAP and SAP kinases in mammalian cells

Cohen, P.

Principal Investigator(s):

1997

Role of translocation in the activation and function of protein kinase B

Andjelkovic, M., Alessi, D. R., Meier, R., Fernandez, A., Lamb, N. J., Frech, M., Cron, P., Cohen, P., Lucocq, J. M., Hemmings, B. A.

Principal Investigator(s):

Dario Alessi, Philip Cohen

1997

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., Cohen, P.

Principal Investigator(s):

Dario Alessi, Philip Cohen

1997

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

Alessi, D. R., Deak, M., Casamayor, A., Caudwell, F. B., Morrice, N., Norman, D. G., Gaffney, P., Reese, C. B., MacDougall, C. N., Harbison, D., Ashworth, A., Bownes, M.

Principal Investigator(s):

1997

The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase

Alessi, D. R.

Principal Investigator(s):

1997

A stress-activated kinase cascade can mediate the activation of tyrosine hydroxylase in chromaffin cells

Thomas, G. M., Haavik, J., Cohen, P.

Principal Investigator(s):

1997

Don't leave dignity out of the cloning debate

Labib, K.

Principal Investigator(s):

1997

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2

Tan, Y., Rouse, J., Zhang, A. H., Cariati, S., Cohen, P., Comb, M. J.

Principal Investigator(s):

Philip Cohen, John Rouse

1996