Research | Publications

Year

Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli

Hazzalin, C. A., Cuenda, A., Cano, E., Cohen, P., Mahadevan, L. C.

Principal Investigator(s):
Philip Cohen
1997

Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases

Goedert, M., Hasegawa, M., Jakes, R., Lawler, S., Cuenda, A., Cohen, P.

Principal Investigator(s):
Philip Cohen
1997

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); Comparison of its substrate specificity with that of other SAP kinases

Goedert, M., Cuenda, A., Craxton, M., Jakes, R., Cohen, P.

Principal Investigator(s):
Philip Cohen
1997

Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades

Deprez, J., Vertommen, D., Alessi, D. R., Hue, L., Rider, M. H.

Principal Investigator(s):
Dario Alessi
1997
PubMed

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

Cuenda, A., Cohen, P., Buee-Scherrer, V., Goedert, M.

Principal Investigator(s):
Philip Cohen
1997
PubMed

Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue

Cross, D. A. E., Watt, P. W., Shaw, M., vanderKaay, J., Downes, C. P., Holder, J. C., Cohen, P.

Principal Investigator(s):
Philip Cohen
1997

PDK1, one of the missing links in insulin signal transduction?

Cohen, P., Alessi, D. R., Cross, D. A.

Principal Investigator(s):
Dario Alessi, Philip Cohen
1997
PubMed

The search for physiological substrates of MAP and SAP kinases in mammalian cells

Cohen, P.

Principal Investigator(s):
Philip Cohen
1997

Role of translocation in the activation and function of protein kinase B

Andjelkovic, M., Alessi, D. R., Meier, R., Fernandez, A., Lamb, N. J., Frech, M., Cron, P., Cohen, P., Lucocq, J. M., Hemmings, B. A.

Principal Investigator(s):
Dario Alessi, Philip Cohen
1997
PubMed

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., Cohen, P.

Principal Investigator(s):
Dario Alessi, Philip Cohen
1997
PubMed

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

Alessi, D. R., Deak, M., Casamayor, A., Caudwell, F. B., Morrice, N., Norman, D. G., Gaffney, P., Reese, C. B., MacDougall, C. N., Harbison, D., Ashworth, A., Bownes, M.

Principal Investigator(s):
Dario Alessi
1997
PubMed

The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase

Alessi, D. R.

Principal Investigator(s):
Dario Alessi
1997
PubMed

A stress-activated kinase cascade can mediate the activation of tyrosine hydroxylase in chromaffin cells

Thomas, G. M., Haavik, J., Cohen, P.

Principal Investigator(s):
Philip Cohen
1997
PubMed

Don't leave dignity out of the cloning debate

Labib, K.

Principal Investigator(s):
Karim Labib
1997
PubMed

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2

Tan, Y., Rouse, J., Zhang, A. H., Cariati, S., Cohen, P., Comb, M. J.

Principal Investigator(s):
Philip Cohen, John Rouse
1996

Cellular stresses and cytokines activate multiple mitogen-activated-protein kinase kinase homologues in PC12 and KB cells

Meier, R., Rouse, J., Cuenda, A., Nebreda, A. R., Cohen, P.

Principal Investigator(s):
Philip Cohen, John Rouse
1996
PubMed

The protein kinase Akt binds to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

James, S. R., Downes, C. P., Gigg, R. , Grove, S. J. A. , Holmes, A. B., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
1996

p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient

Hazzalin, C. A., Cano, E., Cuenda, A., Barratt, M. J., Cohen, P., Mahadevan, L. C.

Principal Investigator(s):
Philip Cohen
1996

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase

Groom, L. A., Sneddon, A. A., Alessi, D. R., Dowd, S., Keyse, S. M.

Principal Investigator(s):
Dario Alessi
1996
PubMed

Cloning and expression of cytosolic phospholipase A(2) (cPLA(2)) and a naturally occurring variant - Phosphorylation of Ser505 of recombinant cPLA(2) by p42 mitogen-activated protein kinase results in an increase in specific activity

Gordon, R. D., Leighton, I. A., Campbell, D. G., Cohen, P., Creaney, A., Wilton, D. C., Masters, D. J., Ritchie, G. A. F., Mott, R., Taylor, I. W. F., Bundell, K. R., Douglas, L., Morten, J., Needham, M.

Principal Investigator(s):
Philip Cohen
1996