Research | Publications

Year

Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

Labib, K., Diffley, J. F.

Principal Investigator(s):
Karim Labib
2001
PubMed

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

Williams, M. R., Arthur, J. S., Balendran, A., van der Kaay, J., Poli, V., Cohen, P., Alessi, D. R.

Principal Investigator(s):
Dario Alessi, Philip Cohen
2000
PubMed

Phosphorylation of the skeletal muscle glycogen-targetting subunit of protein phosphatase 1 in response to adrenaline in vivo

Walker, K. S., Watt, P. W., Cohen, P.

Principal Investigator(s):
Philip Cohen
2000
PubMed

The PI3K-PDK1 connection: more than just a road to PKB

Vanhaesebroeck, B., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2000
PubMed

Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity

Schmoll, D., Walker, K. S., Alessi, D. R., Grempler, R., Burchell, A., Guo, S., Walther, R., Unterman, T. G.

Principal Investigator(s):
Dario Alessi
2000
PubMed

Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1

Ryder, J. W., Fahlman, R., Wallberg-Henriksson, H., Alessi, D. R., Krook, A., Zierath, J. R.

Principal Investigator(s):
Dario Alessi
2000
PubMed

Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155

Lizcano, J. M., Morrice, N., Cohen, P.

Principal Investigator(s):
Philip Cohen
2000
PubMed

Effects of exercise on mitogen- and stress-activated kinase signal transduction in human skeletal muscle

Krook, A., Widegren, U., Jiang, X. J., Henriksson, J., Wallberg-Henriksson, H., Alessi, D., Zierath, J. R.

Principal Investigator(s):
Dario Alessi
2000
PubMed

Serine 727 phosphorylation and activation of cytosolic phospholipase A(2) by MNK1-related protein kinases

Hefner, Y., Borsch-Haubold, A. G., Murakami, M., Wilde, J. I., Pasquet, S., Schieltz, D., Ghomashchi, F., Yates, J. R., Armstrong, C. G., Paterson, A., Cohen, P., Fukunaga, R., Hunter, T., Kudo, I., Watson, S. P., Gelb, M. H.

Principal Investigator(s):
Philip Cohen
2000

Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1 potential involvement of src kinase

Grillo, S., Gremeaux, T., Casamayor, A., Alessi, D. R., Le Marchand-Brustel, Y., Tanti, J. F.

Principal Investigator(s):
Dario Alessi
2000
PubMed

Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7

Fleming, Y., Armstrong, C. G., Morrice, N., Paterson, A., Goedert, M., Cohen, P.

Principal Investigator(s):
Philip Cohen
2000
PubMed

Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase

Dowler, S., Montalvo, L., Cantrell, D., Morrice, N., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2000
PubMed

Identification of PH domains with novel phosphoinositide binding specificities

Dowler, S., Currie, R. A. , Campbell, D. G., Deak, M., Downes, C. P., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2000

Partial purification and characterization of a wortmannin-sensitive and insulin-stimulated protein kinase that activates heart 6-phosphofructo-2-kinase

Deprez, J., Bertrand, L., Alessi, D. R., Krause, U., Hue, L., Rider, M. H.

Principal Investigator(s):
Dario Alessi
2000
PubMed

Specificity and mechanism of action of some commonly used protein kinase inhibitors

Davies, S. P., Reddy, H., Caivano, M., Cohen, P.

Principal Investigator(s):
Philip Cohen
2000
PubMed

Use of kinase inhibitors to dissect signaling pathways

Cuenda, A., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2000
PubMed

The regulation of protein function by multisite phosphorylation--a 25 year update

Cohen, P.

Principal Investigator(s):
Philip Cohen
2000
PubMed

Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages

Caivano, M., Cohen, P.

Principal Investigator(s):
Philip Cohen
2000
PubMed

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

Biondi, R. M., Cheung, P. C., Casamayor, A., Deak, M., Currie, R. A., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2000
PubMed

Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms

Balendran, A., Hare, G. R., Kieloch, A., Williams, M. R., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2000
PubMed