Research | Publications

Year

Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway

Mody, N., Leitch, J., Armstrong, C., Dixon, J., Cohen, P.

Principal Investigator(s):
Philip Cohen
2001
PubMed

Antiischemic effects of SB203580 are mediated through the inhibition of p38 alpha mitogen-activated protein kinase - Evidence from ectopic expression of an inhibition-resistant kinase

Martin, J. L., Avkiran, M., Quinlan, R. A., Cohen, P., Marber, M. S.

Principal Investigator(s):
Philip Cohen
2001

Phosphoinositide-regulated kinases and phosphoinositide phosphatases

Leslie, N. R., Biondi, R. M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2001
PubMed

PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

Lawlor, M. A., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2001
PubMed

Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms

Lang, F., Cohen, P.

Principal Investigator(s):
Philip Cohen
2001
PubMed

A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta

Knebel, A., Morrice, N., Cohen, P.

Principal Investigator(s):
Philip Cohen
2001
PubMed

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

Frame, S., Cohen, P., Biondi, R. M.

Principal Investigator(s):
Philip Cohen
2001
PubMed

GSK3 takes centre stage more than 20 years after its discovery

Frame, S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2001
PubMed

An essential role for calmodulin in regulating human T cell aggregation

Fagerholm, S. C., Prescott, A., Cohen, P., Gahmberg, C. G.

Principal Investigator(s):
Philip Cohen
2001
PubMed

The renaissance of GSK3

Cohen, P., Frame, S.

Principal Investigator(s):
Philip Cohen
2001
PubMed

The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture

Cohen, P.

Principal Investigator(s):
Philip Cohen
2001
PubMed

Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi

Cheung, P. C., Trinkle-Mulcahy, L., Cohen, P., Lucocq, J. M.

Principal Investigator(s):
Philip Cohen
2001
PubMed

The induction of cyclooxygenase-2 mRNA in macrophages is biphasic and requires both CCAAT enhancer-binding protein beta (C/EBP beta ) and C/EBP delta transcription factors

Caivano, M., Gorgoni, B., Cohen, P., Poli, V.

Principal Investigator(s):
Philip Cohen
2001
PubMed

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB

Biondi, R. M., Kieloch, A., Currie, R. A., Deak, M., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2001
PubMed

Mitogen-activated protein kinases

Arthur, S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2001

MAPK-activated protein kinases

Arthur, S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2001

Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture

Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2001
PubMed

Tiny TIM: a small, tetrameric, hyperthermostable triosephosphate isomerase

Walden, H., Bell, G. S., Russell, R. J., Siebers, B., Hensel, R., Taylor, G. L.

2001
PubMed

Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis

Lee, M. J., Thangada, S., Paik, J. H., Sapkota, G. P., Ancellin, N., Chae, S. S., Wu, M., Morales-Ruiz, M., Sessa, W. C., Alessi, D. R., Hla, T.

Principal Investigator(s):
Dario Alessi, Gopal Sapkota
2001
PubMed

MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint

Labib, K., Kearsey, S. E., Diffley, J. F.

Principal Investigator(s):
Karim Labib
2001
PubMed