Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

2001

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

Frame, S., Cohen, P., Biondi, R. M.

Principal Investigator(s):

2001

GSK3 takes centre stage more than 20 years after its discovery

Frame, S., Cohen, P.

Principal Investigator(s):

2001

An essential role for calmodulin in regulating human T cell aggregation

Fagerholm, S. C., Prescott, A., Cohen, P., Gahmberg, C. G.

Principal Investigator(s):

2001

The renaissance of GSK3

Cohen, P., Frame, S.

Principal Investigator(s):

2001

The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture

Cohen, P.

Principal Investigator(s):

2001

Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi

Cheung, P. C., Trinkle-Mulcahy, L., Cohen, P., Lucocq, J. M.

Principal Investigator(s):

2001

The induction of cyclooxygenase-2 mRNA in macrophages is biphasic and requires both CCAAT enhancer-binding protein beta (C/EBP beta ) and C/EBP delta transcription factors

Caivano, M., Gorgoni, B., Cohen, P., Poli, V.

Principal Investigator(s):

2001

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB

Biondi, R. M., Kieloch, A., Currie, R. A., Deak, M., Alessi, D. R.

Principal Investigator(s):

2001

Mitogen-activated protein kinases

Arthur, S., Cohen, P.

Principal Investigator(s):

2001

MAPK-activated protein kinases

Arthur, S., Cohen, P.

Principal Investigator(s):

2001

Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture

Alessi, D. R.

Principal Investigator(s):

2001

Tiny TIM: a small, tetrameric, hyperthermostable triosephosphate isomerase

Walden, H., Bell, G. S., Russell, R. J., Siebers, B., Hensel, R., Taylor, G. L.

Principal Investigator(s):

Helen Walden

2001

Dario Alessi, Gopal Sapkota

Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis

Lee, M. J., Thangada, S., Paik, J. H., Sapkota, G. P., Ancellin, N., Chae, S. S., Wu, M., Morales-Ruiz, M., Sessa, W. C., Alessi, D. R., Hla, T.

Principal Investigator(s):

2001

MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint

Labib, K., Kearsey, S. E., Diffley, J. F.

Principal Investigator(s):

Karim Labib

2001

Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

Labib, K., Diffley, J. F.

Principal Investigator(s):

Karim Labib

2001

Dario Alessi, Philip Cohen

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

Williams, M. R., Arthur, J. S., Balendran, A., van der Kaay, J., Poli, V., Cohen, P., Alessi, D. R.

Principal Investigator(s):

2000

Phosphorylation of the skeletal muscle glycogen-targetting subunit of protein phosphatase 1 in response to adrenaline in vivo

Walker, K. S., Watt, P. W., Cohen, P.

Principal Investigator(s):

2000

The PI3K-PDK1 connection: more than just a road to PKB

Vanhaesebroeck, B., Alessi, D. R.

Principal Investigator(s):

2000

Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity

Schmoll, D., Walker, K. S., Alessi, D. R., Grempler, R., Burchell, A., Guo, S., Walther, R., Unterman, T. G.

Principal Investigator(s):

2000