Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

1999

Effect of SB 203580 on the activity of c-Raf in vitro and in vivo

Hall-Jackson, C. A., Goedert, M., Hedge, P., Cohen, P.

Principal Investigator(s):

1999

Paradoxical activation of Raf by a novel Raf inhibitor

Hall-Jackson, C. A., Eyers, P. A., Cohen, P., Goedert, M., Boyle, F. T., Hewitt, N., Plant, H., Hedge, P.

Principal Investigator(s):

1999

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

Guo, S. D., Rena, G., Cichy, S., He, X. W., Cohen, P., Unterman, T.

Principal Investigator(s):

1999

Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580

Eyers, P. A., van den, IJssel P., Quinlan, R. A., Goedert, M., Cohen, P.

Principal Investigator(s):

1999

DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides

Dowler, S., Currie, R. A., Downes, C. P., Alessi, D. R.

Principal Investigator(s):

1999

Characterisation of a plant 3-phosphoinositide-dependent protein kinase-1 homologue which contains a pleckstrin homology domain

Deak, M., Casamayor, A., Currie, R. A., Downes, C. P., Alessi, D. R.

Principal Investigator(s):

1999

Dario Alessi, Philip Cohen

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

Currie, R. A., Walker, K. S., Gray, A., Deak, M., Casamayor, A., Downes, C. P., Cohen, P., Alessi, D. R., Lucocq, J.

Principal Investigator(s):

1999

Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis

Cuenda, A., Cohen, P.

Principal Investigator(s):

1999

Understanding Insulin signalling

Cohen, P.

Principal Investigator(s):

1999

The 1997 Louis Jeantet Prize Lecture. Role of protein phosphorylation in human health and disease

Cohen, P.

Principal Investigator(s):

1999

The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction

Cohen, P.

Principal Investigator(s):

1999

The development and therapeutic potential of protein kinase inhibitors

Cohen, P.

Principal Investigator(s):

1999

Alternative splicing regulates the production of ARD-1 endoribonuclease and NIPP-1, an inhibitor of protein phosphatase-1, as isoforms encoded by the same gene

Chang, A. C., Sohlberg, B., Trinkle-Mulcahy, L., Claverie-Martin, F., Cohen, P., Cohen, S. N.

Principal Investigator(s):

1999

Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast

Casamayor, A., Torrance, P. D., Kobayashi, T., Thorner, J., Alessi, D. R.

Principal Investigator(s):

1999

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

Casamayor, A., Morrice, N. A., Alessi, D. R.

Principal Investigator(s):

1999

Phosphorylation of cytosolic phospholipase A(2) in platelets is mediated by multiple stress-activated protein kinase pathways

Borsch-Haubold, A. G., Ghomashchi, F., Pasquet, S., Goedert, M., Cohen, P., Gelb, M. H., Watson, S. P.

Principal Investigator(s):

1999

Heart 6-phosphofructo-2-kinase activation by insulin results from Ser-466 and Ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase B

Bertrand, L., Alessi, D. R., Deprez, J., Deak, M., Viaene, E., Rider, M. H., Hue, L.

Principal Investigator(s):

1999

Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252

Balendran, A., Currie, R., Armstrong, C. G., Avruch, J., Alessi, D. R.

Principal Investigator(s):

1999