Structures and Mechanisms of Ubiquitin-like Signalling in Immunity
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We are recruiting a highly motivated Postdoctoral Researcher to join the laboratory of Dr Kirby Swatek. The goal of the Swatek lab is to understand the immunoregulatory roles of a ubiquitin-like modifier called Interferon-Stimulated Gene 15 (ISG15). As its name suggests, ISG15 is highly upregulated in interferon-treated and virus-infected cells and labels thousands of proteins to help shape the host immune response. However, the mechanisms underlying ISG15's contribution to immunity are largely unknown. This project focuses on the structural analysis of the writers of the ISG15 system. The postdoc will utilise several exciting new tools and reagents in the lab and expand on our recent progress in the area. A significant portion of the structural work will be performed using a brand-new Glacios Cryo Transmission Electron Microscope (Cryo-TEM) conveniently located in the School of Life Sciences. The successful applicant will gain hands-on training in Cryo-EM and work closely with the Cryo-EM facility. The project complements our efforts to understand the cellular roles of ISG15 modifications, and therefore, the postholder will have several opportunities for internal and external collaborations.
Your priorities will include:
- Structural analysis of the ISG15 system.
- Performing a wide array of multidisciplinary techniques.
- Advising and mentoring undergraduate and PhD students.
- Presenting your research at lab meetings, workshops, and conferences.
- Writing manuscripts for publication.
Candidate requirements:
- PhD (or will complete your PhD studies within six months of the application deadline).
- A track record of academic success.
- Expertise in cryo-EM and/or X-ray crystallography is highly desirable.
- Experience in chemical biology, biochemistry, and purification of multiprotein complexes.
- A strong background in immune signalling and ubiquitin biology would be advantageous.
- The ability to teach a small multidisciplinary team of enthusiastic scientists.
- Excellent communication skills (both verbal and written).
For further information about this position please contact Dr Kirby Swatek, kswatek001@dundee.ac.uk . To find out more about Dr Kirby Swatek's lab, please visit https://www.ppu.mrc.ac.uk/research/principal-investigator/kirby-swatek.
To apply on-line please visit: www.dundee.ac.uk/jobs. If you are unable to apply on-line please contact Human Resources on (01382) 386209 (answering machine) for an application pack. Please quote reference number
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