The Medical Research Council’s Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) is a world-leading research division, which is embedded within the School of Life Sciences at the University of Dundee. The major aim of the MRC PPU is to advance our understanding of the roles of protein phosphorylation and ubiquitylation in cell biology and human disease. We currently have 12 research groups and ~100 staff members. Many world leading researchers in the field of signal transduction have trained within the MRC PPU. Our focus is on understanding fundamental biology of relevance to better understanding and treating diseases caused by abnormalities in phosphorylation or ubiquitylation networks. We also have an interest in developing new approaches and tools to better interrogate phosphorylation and ubiquitylation pathways. Our Unit is also committed to train the next generation of scientists who will advance our understanding in this crucial area of medical research.

We invite applications for a core funded Principal Investigator position at the tenured or tenure-track level, depending on experience, and welcome applications from researchers representing all minority groups (see below – “Diversity and equality of opportunity. The successful applicant would receive MRC-PPU core funding that would support Postdoctoral Research Assistants and Ph.D. students together with a generous consumables budget. Applicants should have an exciting research programme aimed at understanding the role of phosphorylation and/or ubiquitylation pathways in cell biology of relevance to human disease. We are keen to receive applications from candidates with interest/expertise in all subject areas that might complement and enhance the current work of the MRC PPU and are also interested in applicants with expertise and interest in chemical biology and/or the molecular mechanisms of human disease. The newly established group would have full access to the MRC PPU's outstanding research facilities and service teams including DNA cloning, Production of Proteins and Antibodies, Mass Spectrometry, as well as to other facilities in the School of Life Sciences, such as flow cytometry and advanced imaging.

Candidate requirements include:

-PhD in a relevant subject
-Proven track record in research and an excellent publication track record
-Significant research programme in the area of protein phosphorylation or ubiquitylation research, complementing other research within the MRC-PPU
-Ability to write successful grant applications
-Significant knowledge of the protein phosphorylation and/or ubiquitylation research areas.

The positions will be on the University of Dundee Grade 8 or Grade 9 salary scale depending on experience

For informal enquiries please contact Dario Alessi (MRC PPU Director) d.r.alessi@dundee.ac.uk