Teaser: Our recent work characterizing ARIH1 activity represents the most quantitative effort to date for comparing the efficiencies of canonical and non-canonical ubiquitylation by an E3. I will share these results with an emphasis on experimental considerations such that others may perform similar assays in their own labs.

About the Speaker: Gary Kleiger received his PhD in 2002 with David Eisenberg, initially focusing on x-ray crystallography and later transitioning into bioinformatics and how conserved amino acid sequence motifs confer protein function. They then did their post-doctoral fellowship with Ray Deshaies at Caltech, employing novel biochemical assays to study the SCF family of ubiquitin ligases. They joined the University of Nevada, Las Vegas as Assistant Professor in 2011 and was named Chair of the department of Chemistry and Biochemistry in 2023. Dr. Kleiger's research program investigates the structure and function of Cullin-RING ligases and their associated ubiquitin-carrying enzymes.

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